Targeting metabolic/epigenetic pathways: a potential strategy for cancer therapy in diffuse intrinsic pontine gliomas

摘要

A recent study published in Cancer Cell by Chan Chung andcolleagues demonstrated that H3.3K27M mutation in diffuseintrinsic pontine gliomas (DIPGs) potentiated glycolysis, tricarboxylicacid cycle, and glutaminolysis metabolism with upregulatedalpha-ketoglutarate (α-KG), which contributed to sustain anepigenetic status marked by H3K27me3 deficiency and thatinterruption of these metabolic/epigenetic pathways representeda promising strategy for the treatment of DIPGs, as reprted byChung, C. et al.