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Signal transduction and targeted therapy.

中文名称：信号转导和靶向治疗。

ISSN：2095-9907
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发文量：337

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1.DNA-PKcs promotes alcohol-related liver disease by activating Drp1-related mitochondrial fission and repressing FUNDC1-required mitophagy

机译：通过激活DRP1相关的线粒体裂变和压抑基金1所需的乳化剂，促进酒精相关肝病与饮酒有关的肝病
- 作者：Hao Zhou;Pingjun Zhu;Jin Wang;Sam Toan;Jun Ren
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
2.The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts

机译：β-catenin / yap信号轴是黑素瘤相关成纤维细胞的关键调节器
- 作者：Tianyi Liu;Linli Zhou;Kun Yang;Kentaro Iwasawa;Ana Luisa Kadekaro;Takanori Takebe;Thomas Andl;Yuhang Zhang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
3.PROTACs: great opportunities for academia and industry

机译：Protacs：学术界和工业的巨大机会
- 作者：Xiuyun Sun;Hongying Gao;Yiqing Yang;Ming He;Yue Wu;Yugang Song;Yan Tong;Yu Rao
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
4.The emerging treatment landscape of targeted therapy in non-small-cell lung cancer

机译：非小细胞肺癌靶向治疗的新出现治疗景观
- 作者：Min Yuan;Li-Li Huang;Jian-Hua Chen;Jie Wu;Qing Xu
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
5.Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials

机译：针对癌症治疗的表观遗传调节因子：临床试验的机制和进展
- 作者：Yuan Cheng;Cai He;Manni Wang;Xuelei Ma;Fei Mo;Shengyong Yang;Junhong Han;Xiawei Wei
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
6.MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models

机译：MKP-1减少了Aβ代和缓解阿尔茨海默病疾病模型的认知障碍
- 作者：Yehong Du;Yexiang Du;Yun Zhang;Zhilin Huang;Min Fu;Junjie Li;Yayan Pang;Peng Lei;Yu Tian Wang;Weihong Song;Guiqiong He;Zhifang Dong
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
7.Dickkopf-1 contributes to hepatocellular carcinoma tumorigenesis by activating the Wnt/β-catenin signaling pathway

机译：Dickkopf-1通过激活Wnt /β-catenin信号通路来促进肝细胞癌肿瘤内核
- 作者：Rui Zhang;Hao-Ming Lin;Ruth Broering;Xiang-de Shi;Xian-huan Yu;Lei-bo Xu;Wen-rui Wu;Chao Liu
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
8.Tumor-suppressive function and mechanism of HOXB13 in right-sided colon cancer

机译：右侧结肠癌HoxB13的肿瘤抑制功能及机制
- 作者：Binbin Xie;Bingjun Bai;Yuzi Xu;Yunlong Liu;Yiming Lv;Xing Gao;Fei Wu;Zhipeng Fang;Ying Lou;Hongming Pan;Weidong Han
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
9.Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence

机译：Seryl TRNA合成酶与POT1配合以调节端粒长度和细胞衰老
- 作者：Yingxi Li;Xiyang Li;Mei Cao;Yuke Jiang;Jie Yan;Ze Liu;Rongcun Yang;Xu Chen;Peiqing Sun;Rong Xiang;Longlong Wang;Yi Shi
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
10.PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death

机译：PCDH17通过诱导细胞凋亡和自噬细胞死亡，增加结肠直肠癌至5-氟尿嘧啶的敏感性
- 作者：Shuiping Liu;Haoming Lin;Da Wang;Qiang Li;Hong Luo;Guoxiong Li;Xiaohui Chen;Yongqiang Li;Peng Chen;Bingtao Zhai;Wengang Wang;Ruonan Zhang;Bi Chen;Mingming Zhang;Xuemeng Han;Qiujie Li;Liuxi Chen;Ying Liu;Xiaying Chen;Guohua Li;Yu Xiang;Ting Duan;Jiao Feng;Jianshu Lou;Xingxing Huang;Qin Zhang;Ting Pan;Lili Yan;Ting Jin;Wenzheng Zhang;Lvjia Zhuo;Yitian Sun;Tian Xie;Xinbing Sui
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
11.Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3Kα inhibition in breast cancer

机译：无偏的筛选表明，阻断出口1克服对乳腺癌中PI3Kα抑制的抵抗力
- 作者：Xue-Ling Liu;Bo-Bo Wang;Yi Wang;Yu-Xiang Wang;Chun-hao Yang;Cun Tan;Xi Zhang;Qiao-jun He;Jian Ding;Ling-Hua Meng
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
12.Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9

机译：化合物Cinobufotalin通过拮抗其结合伴侣MyH9拮抗诱导FoxO1刺激的顺铂敏感性
- 作者：YongHao Li;Xiong Liu;Xian Lin;Menyang Zhao;Yanyi Xiao;Chen Liu;Zixi Liang;Zelong Lin;Renhui Yi;Zibo Tang;Jiahao Liu;Xin Li;Qingping Jiang;Libo Li;Yinyin Xie;Zhen Liu;Weiyi Fang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
13.Simultaneous cotargeting of ATR and RNA Polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia

机译：ATR和RNA聚合酶的同时性CoTargeting I转录证明了对急性髓鞘性白血病的协同抗血糖作用
- 作者：Tingting Wang;Margaret Shatara;Fangbing Liu;Tristan Knight;Holly Edwards;Guan Wang;Hai Lin;Yue Wang;Jeffrey W. Taub;Yubin Ge
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
14.Clonal replacement of novel T cells: a new phenomenon in the tumor microenvironment following PD-1 blockade

机译：新型T细胞的克隆替代：PD-1阻断后肿瘤微环境中的一种新现象
- 作者：Xue Li;Manni Wang;Rong Xiang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
15.Author Correction: History and progress of hypotheses and clinical trials for Alzheimer’s disease

机译：作者矫正：Alzheimer疾病的假设和临床试验的历史和进展
- 作者：Pei-Pei Liu;Yi Xie;Xiao-Yan Meng;Jian-Sheng Kang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
16.Genetically engineered T cells for cancer immunotherapy

机译：癌症免疫疗法的转基因T细胞
- 作者：Dan Li;Xue Li;Wei-Lin Zhou;Yong Huang;Xiao Liang;Lin Jiang;Xiao Yang;Jie Sun;Zonghai Li;Wei-Dong Han;Wei Wang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
17.BE-PIGS: a base-editing tool with deaminases inlaid into Cas9 PI domain significantly expanded the editing scope

机译：Be-Pigs：底座编辑工具与携带成Cas9 PI域的脱蛋白酶显着扩展了编辑范围
- 作者：Yanhong Wang;Lifang Zhou;Nan Liu;Shaohua Yao
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
18.Targeting cell signaling in allergic asthma

机译：靶向过敏性哮喘中的细胞信号
- 作者：Seyyed Shamsadin Athari
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
19.The antimicrobial peptide PFR induces necroptosis mediated by ER stress and elevated cytoplasmic calcium and mitochondrial ROS levels: cooperation with Ara-C to act against acute myeloid leukemia

机译：抗微生物肽PFR诱导由ER应激和升高的细胞质钙和线粒体ROS水平介导的Necroptosis：与ARA-C合作，采取急性髓性白血病
- 作者：Yudie Lv;Gang Shao;Qiyu Zhang;Xi Wang;Yueming Meng;Lingfei Wang;Feiyan Huang;Tianxin Yang;Yuanting Jin;Caiyun Fu
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
20.Allelic frequency differences of DAOA variants between Caucasians and Asians and their association with major mood disorders

机译：高加索人员与亚洲人与主要情绪障碍的关系等位基因频率差异
- 作者：Zhihua Yang;Shuang Zhang;Fuquan Zhang;Yao Yao;Kwangwoo Kim;David Meyre;Hongmei Zhang;Hai Liao;Shuquan Rao;Xinhe Huang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
21.The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports

机译：脑缺血性卒中与胶质瘤之间的相互关系：近期报告的综合研究
- 作者：Mrinal K. Ghosh;Dipankar Chakraborty;Sibani Sarkar;Arijit Bhowmik;Malini Basu
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
22.Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

机译：通过肠道微生物组搅拌宿主免疫，新陈代谢和肾外肿瘤的操纵
- 作者：Ziying Zhang;Haosheng Tang;Peng Chen;Hui Xie;Yongguang Tao
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
23.Local delivery of arsenic trioxide nanoparticles for hepatocellular carcinoma treatment

机译：用于肝细胞癌治疗的砷三氧化砷纳米粒子的局部递送
- 作者：Jian Hu;Yi Dong;Li Ding;Yang Dong;Zhihua Wu;Wenping Wang;Ming Shen;Yourong Duan
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
24.Targeted therapeutic options and future perspectives for HER2-positive breast cancer

机译：针对Her2阳性乳腺癌的有针对性的治疗选择和未来的观点
- 作者：Jiani Wang;Binghe Xu
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
25.E6-induced selective translation of WNT4 and JIP2 promotes the progression of cervical cancer via a noncanonical WNT signaling pathway

机译：E6诱导的Wnt4和JIP2的选择性翻译通过非甘露透的WNT信号通路促进宫颈癌的进展
- 作者：Lin Zhao;Longlong Wang;Chenglan Zhang;Ze Liu;Yongjun Piao;Jie Yan;Rong Xiang;Yuanqing Yao;Yi Shi
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
26.History and progress of hypotheses and clinical trials for Alzheimer’s disease

机译：Alzheimer疾病假设和临床试验的历史与进展
- 作者：Pei-Pei Liu;Yi Xie;Xiao-Yan Meng;Jian-Sheng Kang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
27.Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

机译：使用基于纳米材料的药物递送载体的慢性疾病的靶向治疗
- 作者：Akhand Pratap Singh;Arpan Biswas;Aparna Shukla;Pralay Maiti
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
28.The effect of selective serotonin reuptake inhibitors on cognitive function in patients with Alzheimer’s disease and vascular dementia: focusing on fluoxetine with long follow-up periods

机译：选择性血清素再摄取抑制剂对阿尔茨海默病和血管痴呆患者认知功能的影响：专注于长期随访期的氟西汀
- 作者：Yi Xie;Pei-Pei Liu;Ya-Jun Lian;Hong-Bo Liu;Jian-Sheng Kang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
29.Author Correction: A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity

机译：作者校正：一种新型癌症疫苗，具有同时在癌细胞中同时产生抗PD-1抗体和GM-CSF的能力，并增强TH1偏置抗肿瘤免疫力
- 作者：Hongwei Tian;Gang Shi;Qin Wang;Yiming Li;Qianmei Yang;Chunlei Li;Guoyou Yang;Min Wu;Qian Xie;Shuang Zhang;Yang Yang;Rong Xiang;Dechao Yu;Yuquan Wei;Hongxin Deng
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
30.miR-124/VAMP3 is a novel therapeutic target for mitigation of surgical trauma-induced microglial activation

机译：miR-124 / Vamp3是一种新的治疗靶标，用于减轻手术创伤诱导的小胶质激活
- 作者：Yan Chen;Jing-xian Sun;Wan-kun Chen;Gen-cheng Wu;Yan-qing Wang;Ke-ying Zhu;Jun Wang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
31.Potent delivery of an MMP inhibitor to the tumor microenvironment with thermosensitive liposomes for the suppression of metastasis and angiogenesis

机译：用热敏脂质体与肿瘤微环境有效地递送MMP抑制剂，用于抑制转移和血管生成
- 作者：Yaqi Lyu;Qingqing Xiao;Lifang Yin;Lei Yang;Wei He
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
32.ReishiMax inhibits mTORC1/2 by activating AMPK and inhibiting IGFR/PI3K/Rheb in tumor cells

机译：Reishimax通过激活AMPK和抑制肿瘤细胞中的IGFR / PI3K / RHES来抑制MTORC1 / 2
- 作者：Didem Sohretoglu;Chao Zhang;Jun Luo;Shile Huang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
33.The proatherosclerotic function of indoleamine 2, 3-dioxygenase 1 in the developmental stage of atherosclerosis

机译：吲哚胺2,3-二恶英酶1在动脉粥样硬化发育阶段的吲哚胺2,3-二恶英酶1
- 作者：Heng Liang;Mantian Chen;Fangfei Qi;Lei Shi;Zhenzhen Duan;Ruoyu Yang;Jinchao He;Bin Lou;Yigang Li;Qing Yang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
34.EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer

机译：EGFR TKI损害SQSTM1的溶酶体依赖性降解以损害肺癌的有效性
- 作者：Lixian Yang;Shilong Ying;Shiman Hu;Xiangtong Zhao;Muchun Li;Miaoqin Chen;Yiran Zhu;Ping Song;Liyuan Zhu;Tingting Jiang;Huimin An;Neelum Aziz Yousafzai;Wenxia Xu;Zhiguo Zhang;Xian Wang;Lifeng Feng;Hongchuan Jin
- 期刊名称：《Signal transduction and targeted therapy.》 | 2019年第1期
35.Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects

机译：基因组编辑技术在人类疾病靶向治疗中的应用：机制，进展和前景
- 作者：Hongyi Li;Yang Yang;Weiqi Hong;Mengyuan Huang;Min Wu;Xia Zhao
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
36.Use of a 6-miRNA panel to distinguish lymphoma from reactive lymphoid hyperplasia

机译：使用6 miRNA面板以区分淋巴瘤免受活性淋巴增生
- 作者：Juanjuan Kang;Sisi Yu;Song Lu;Guohui Xu;Jiang Zhu;Na Yan;Delun Luo;Kai Xu;Zhihui Zhang;Jian Huang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
37.DNA methylation markers in the diagnosis and prognosis of common leukemias

机译：DNA甲基化标志物在常见白血病的诊断和预后
- 作者：Hua Jiang;Zhiying Ou;Yingyi He;Meixing Yu;Shaoqing Wu;Gen Li;Jie Zhu;Ru Zhang;Jiayi Wang;Lianghong Zheng;Xiaohong Zhang;Wenge Hao;Liya He;Xiaoqiong Gu;Qingli Quan;Edward Zhang;Huiyan Luo;Wei Wei;Zhihuan Li;Guangxi Zang;Charlotte Zhang;Tina Poon;Daniel Zhang;Ian Ziyar;Run-ze Zhang;Oulan Li;Linhai Cheng;Taylor Shimizu;Xinping Cui;Jian-kang Zhu;Xin Sun;Kang Zhang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
38.Targeting folate receptor β positive tumor-associated macrophages in lung cancer with a folate-modified liposomal complex

机译：靶向叶酸受体β阳性肿瘤相关巨噬细胞肺癌与叶酸改性脂质体复合物
- 作者：Yan Tie;Heng Zheng;Zhiyao He;Jingyun Yang;Bin Shao;Li Liu;Min Luo;Xia Yuan;Yu Liu;Xiangxian Zhang;Hongyi Li;Min Wu;Xiawei Wei
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
39.NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-positive myeloproliferative neoplasm cells

机译：NT157具有抗肿瘤效果，抑制JAK2V617F阳性髓鞘瘤细胞中的IRS1 / 2和STAT3 / 5
- 作者：Bruna Alves Fenerich;Jaqueline Cristina Fernandes;Ana Paula Nunes Rodrigues Alves;Juan Luiz Coelho-Silva;Renata Scopim-Ribeiro;Priscila Santos Scheucher;Christopher A. Eide;Cristina E. Tognon;Brian J. Druker;Eduardo Magalh?es Rego;Jo?o Agostinho Machado-Neto;Fabiola Traina
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
40.PIM kinase inhibition: co-targeted therapeutic approaches in prostate cancer

机译：PIM激酶抑制：前列腺癌中的共靶向治疗方法
- 作者：Sabina Luszczak;Christopher Kumar;Vignesh Krishna Sathyadevan;Benjamin S. Simpson;Kathy A. Gately;Hayley C. Whitaker;Susan Heavey
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
41.Fibronectin-targeted dual-acting micelles for combination therapy of metastatic breast cancer

机译：用于联合乳腺癌的联合治疗的纤连蛋白靶向双作用胶束
- 作者：Zhuoran Gong;Min Chen;Qiushi Ren;Xiuli Yue;Zhifei Dai
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
42.Targeting cancer stem cell pathways for cancer therapy

机译：靶向癌症干细胞途径癌症治疗
- 作者：Liqun Yang;Pengfei Shi;Gaichao Zhao;Jie Xu;Wen Peng;Jiayi Zhang;Guanghui Zhang;Xiaowen Wang;Zhen Dong;Fei Chen;Hongjuan Cui
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
43.Potential targeted therapy and diagnosis based on novel insight into growth factors, receptors, and downstream effectors in acute kidney injury and acute kidney injury-chronic kidney disease progression

机译：潜在的靶向治疗和诊断基于新的洞察力因子，受体和急性肾脏损伤和急性肾损伤 - 慢性肾病进展中的生长因子，受体和下游效应
- 作者：Li Gao;Xiang Zhong;Juan Jin;Jun Li;Xiao-ming Meng
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
44.Silencing MYH9 blocks HBx-induced GSK3β ubiquitination and degradation to inhibit tumor stemness in hepatocellular carcinoma

机译：沉默的MyH9阻断HBX诱导的GSK3β泛素化和降解，以抑制肝细胞癌中的肿瘤茎
- 作者：Xian Lin;Ai-min Li;Yong-Hao Li;Rong-Cheng Luo;Yu-Jiao Zou;Yi-Yi Liu;Chen Liu;Ying-Ying Xie;Shi Zuo;Zhan Liu;Zhen Liu;Wei-Yi Fang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
45.Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn–AhR–AQP4 signaling pathway

机译：IDO1和TDO都通过Kyn-AHR-AQP4信号通路促进了胶质瘤的恶性肿瘤
- 作者：Lisha Du;Zikang Xing;Bangbao Tao;Tianqi Li;Dan Yang;Weirui Li;Yuanting Zheng;Chunxiang Kuang;Qing Yang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
46.Semaphorins or Frizzled –it is the receptor that direct the action of clostridial glucosylating toxins

机译：信号蛋白或毛躁 - 是指导梭菌葡萄糖型毒素的作用的受体
- 作者：Klaus Aktories
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
47.Targeting multiple epitopes on the spike protein: a new hope for COVID-19 antibody therapy

机译：针对穗蛋白质的多个表位：Covid-19抗体治疗的新希望
- 作者：Yeping Sun;Bostjan Kobe;Jianxun Qi
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
48.T H 17 cells…Sorting the good out from the bad

机译：t h 17细胞......从坏的地方排序
- 作者：Junwei Li;Le Jiang;Yongxiang Yi;Pradeep Kumar Sacitharan
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
49.Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS

机译：新的洞察力诱导对流感的易感性：皮质酮对MFN2介导的泛素的泛素的泛素的泛素抗衡
- 作者：Zhuo Luo;Li-Fang Liu;Ying-Nan Jiang;Lu-Ping Tang;Wen Li;Shu-Hua Ouyang;Long-Fang Tu;Yan-Ping Wu;Hai-Biao Gong;Chang-Yu Yan;Shan Jiang;Yu-Hui Lu;Tongzheng Liu;Zhenyou Jiang;Hiroshi Kurihara;Yang Yu;Xin-Sheng Yao;Yi-Fang Li;Rong-Rong He
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
50.Carbamylated erythropoietin regulates immune responses and promotes long-term kidney allograft survival through activation of PI3K/AKT signaling

机译：氨基甲酰化的促红细胞生成素通过激活PI3K / AKT信号传导来调节免疫应答并促进长期肾同种异体移植物存活
- 作者：Ning Na;Daqiang Zhao;Jinhua Zhang;Jiaqing Wu;Bin Miao;Heng Li;Yingxun Luo;Zuofu Tang;Wensheng Zhang;Joseph A. Bellanti;Song Guo Zheng
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
51.A genome-wide screening for DNA repair genes: much more players than hitherto known

机译：用于DNA修复基因的基因组筛选：比迄今已知的更多参与者
- 作者：Bernd Kaina
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
52.Convalescent plasma therapy for COVID-19: a tried-and-true old strategy?

机译：Covid-19的临时血浆治疗：一项经验和真正的旧战略？
- 作者：Yongzhi Xi
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
53.Type I IFN deficiency: an immunological characteristic of severe COVID-19 patients

机译：I型IFN缺乏：严重Covid-19患者的免疫特征
- 作者：Zhenling Wang;Hailong Pan;Boguang Jiang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
54.Chitinase-3 like-protein-1 function and its role in diseases

机译：几丁质酶-3样蛋白-1蛋白-1功能及其在疾病中的作用
- 作者：Ting Zhao;Zhongping Su;Yingchang Li;Xiaoren Zhang;Qiang You
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
55.CYP2S1 is a synthetic lethal target in BRAF V600E -driven thyroid cancers

机译：CYP2S1是BRAF V600E -DRIVEN甲状腺癌的合成致死靶
- 作者：Yiqi Li;Xi Su;Chao Feng;Siyu Liu;Haixia Guan;Yue Sun;Nongyue He;Meiju Ji;Peng Hou
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
56.VDR–SOX2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment

机译：VDR-SOX2信号传导促进酸性微环境中的结肠直肠癌茎干和恶性肿瘤
- 作者：Pei-Shan Hu;Ting Li;Jin-Fei Lin;Miao-Zhen Qiu;De-Shen Wang;Ze-Xian Liu;Zhan-Hong Chen;Lu-Ping Yang;Xiao-Long Zhang;Qi Zhao;Yan-Xing Chen;Yun-Xin Lu;Qi-Nian Wu;Heng-Ying Pu;Zhao-Lei Zeng;Dan Xie;Huai-Qiang Ju;Hui-Yan Luo;Rui-Hua Xu
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
57.Epitranscriptomics and epiproteomics in cancer drug resistance: therapeutic implications

机译：癌症抗药性癌症患者和副癌细胞瘤：治疗意义
- 作者：Huibin Song;Dongcheng Liu;Shaowei Dong;Leli Zeng;Zhuoxun Wu;Pan Zhao;Litu Zhang;Zhe-Sheng Chen;Chang Zou
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
58.How mammalian piRNAs instruct de novo DNA methylation of transposons

机译：哺乳动物pirnas如何指示德诺DNA甲基的转座子
- 作者：Zhiqing Li;Xiaoyin Tang;En-Zhi Shen
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
59.An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma

机译：预处理活检的个体化免疫签名预测食管鳞状细胞癌患者对Neoadjuvant ChemoraMatio疗法和结果的病理完全反应
- 作者：Chaoqi Zhang;Guochao Zhang;Nan Sun;Zhen Zhang;Liyan Xue;Zhihui Zhang;Haijun Yang;Yuejun Luo;Xiaoli Zheng;Yonglei Zhang;Yufen Yuan;Ruixue Lei;Zhaoyang Yang;Bo Zheng;Le Wang;Yun Che;Feng Wang;Sihui Wang;Shugeng Gao;Qi Xue;Yi Zhang;Jie He
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
60.The p(l)ot thickens: cannabinoid receptors on astroglial mitochondria coordinate animal behaviors by regulating lactate availability for neurons

机译：P（l）ot厚度：通过调节神经元的乳酸乳液可用性来坐标动物行为的大麻素受体
- 作者：Erik Keimpema;Tibor Harkany;Alán Alpár
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
61.Profiling and characterization of SARS-CoV-2 mutants’ infectivity and antigenicity

机译：SARS-COV-2突变体感染性和抗原性的分析和表征
- 作者：Lin Wang;Ling Wang;Hui Zhuang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
62.A new player in the beneficial effects of exercise on the aged brain

机译：一种新的球员，锻炼对老化的大脑
- 作者：M. Llorens-Martín
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
63.COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm

机译：Covid-19激活的Srebp2扰乱胆固醇生物合成，导致细胞因子风暴
- 作者：Wonhwa Lee;June Hong Ahn;Hee Ho Park;Hong Nam Kim;Hyelim Kim;Youngbum Yoo;Hyosoo Shin;Kyung Soo Hong;Jong Geol Jang;Chun Gwon Park;Eun Young Choi;Jong-Sup Bae;Young-Kyo Seo
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
64.Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19

机译：疾病严重程度决定了Covid-19中的SARS-COV-2特异性中和抗体反应
- 作者：Xiangyu Chen;Zhiwei Pan;Shuai Yue;Fei Yu;Junsong Zhang;Yang Yang;Ren Li;Bingfeng Liu;Xiaofan Yang;Leiqiong Gao;Zhirong Li;Yao Lin;Qizhao Huang;Lifan Xu;Jianfang Tang;Li Hu;Jing Zhao;Pinghuang Liu;Guozhong Zhang;Yaokai Chen;Kai Deng;Lilin Ye
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
65.FGF/FGFR signaling in health and disease

机译：FGF / FGFR在健康和疾病中的信号传导
- 作者：Yangli Xie;Nan Su;Jing Yang;Qiaoyan Tan;Shuo Huang;Min Jin;Zhenhong Ni;Bin Zhang;Dali Zhang;Fengtao Luo;Hangang Chen;Xianding Sun;Jian Q. Feng;Huabing Qi;Lin Chen
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
66.GLUT3 induced by AMPK/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies

机译：由AMPK / CREB1轴引起的Glut3是承受能源应力的关键，增强了当前结肠直肠癌疗法的功效
- 作者：Weixing Dai;Ye Xu;Shaobo Mo;Qingguo Li;Jun Yu;Renjie Wang;Yanlei Ma;Yan Ni;Wenqiang Xiang;Lingyu Han;Long Zhang;Sanjun Cai;Jun Qin;Wen-Lian Chen;Wei Jia;Guoxiang Cai
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
67.H3.3S31 phosphorylation: linking transcription elongation to stimulation responses

机译：H3.3S31磷酸化：将转录伸长伸长率连接到刺激反应
- 作者：Hong Wen;Xiaobing Shi
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
68.Mitomycin C enhanced the efficacy of PD-L1 blockade in non-small cell lung cancer

机译：丝霉素C增强了PD-L1阻断在非小细胞肺癌中的疗效
- 作者：Min Luo;Fang Wang;Hong Zhang;Kenneth K. W. To;Shaocong Wu;Zhen Chen;Shaobo Liang;Liwu Fu
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
69.Promising inhibitors targeting M pro : an ideal strategy for anti-SARS-CoV-2 drug discovery

机译：有前途的抑制剂靶向M Pro：抗SARS-COV-2药物发现的理想策略
- 作者：Yi Chen;Guan Wang;Liang Ouyang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
70.Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial

机译：Covid-19患者的人脐带衍生的间充质干细胞治疗：1期临床试验
- 作者：Fanping Meng;Ruonan Xu;Siyu Wang;Zhe Xu;Chao Zhang;Yuanyuan Li;Tao Yang;Lei Shi;Junliang Fu;Tianjun Jiang;Lei Huang;Peng Zhao;Xin Yuan;Xing Fan;Ji-Yuan Zhang;Jinwen Song;Dawei Zhang;Yanmei Jiao;Limin Liu;Chunbao Zhou;Markus Maeurer;Alimuddin Zumla;Ming Shi;Fu-Sheng Wang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
71.IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas

机译：IGF-1R抑制诱导MEK磷酸化以促进结肠癌中的存活
- 作者：Qing Wang;Yan Zhang;Jiang Zhu;Honggang Zheng;Shuntai Chen;Li Chen;Hsin-Sheng Yang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
72.The first human trial of CRISPR-based cell therapy clears safety concerns as new treatment for late-stage lung cancer

机译：基于CRISPR的细胞疗法的第一次人类试验清除了安全问题作为晚期肺癌的新治疗方法
- 作者：Shenghui He
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
73.Human-viral chimera: a novel protein affecting viral virulence and driving host T-cell immunity

机译：人类病毒嵌合体：一种影响病毒毒力和驱动宿主T细胞免疫的新蛋白质
- 作者：Zhenling Wang;Li Zhang;Min Wu
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
74.Molecular features of IGHV3-53-encoded antibodies elicited by SARS-CoV-2

机译：SARS-COV-2引发的IGHV3-53编码抗体的分子特征
- 作者：Francesca Fagiani;Michele Catanzaro;Cristina Lanni
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
75.The updated landscape of tumor microenvironment and drug repurposing

机译：肿瘤微环境的更新景观和药物重新展示
- 作者：Ming-Zhu Jin;Wei-Lin Jin
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
76.Rab22a-NeoF1: a promising target for osteosarcoma patients with lung metastasis

机译：Rab22a-neof1：肺转移患者的骨肉瘤患者有希望的靶标
- 作者：Kai Xie;Xinyi Zhang;Yongguang Tao
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
77.CCDC25: precise navigator for neutrophil extracellular traps on the prometastatic road

机译：CCDC25：Prometastatic道路上嗜中性粒细胞外细胞陷阱的精确导航仪
- 作者：Ruochen Liu;Erhu Zhao;Feng Wang;Hongjuan Cui
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
78.Dietary intervention, a promising adjunct for cancer therapy

机译：膳食干预，癌症治疗的有希望的辅助
- 作者：Rongchen Shi;Hongming Miao
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
79.Addiction to protein kinase C? due to PRKCI gene amplification can be exploited for an aptamer-based targeted therapy in ovarian cancer

机译：对蛋白激酶C的成瘾？由于PRKCI基因扩增，可以利用卵巢癌的适体的靶向治疗
- 作者：Hina Rehmani;Yue Li;Tao Li;Ravi Padia;Ozlem Calbay;Lingtao Jin;Huijun Chen;Shuang Huang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
80.A CRISPR knockout negative screen reveals synergy between CDKs inhibitor and metformin in the treatment of human cancer in vitro and in vivo

机译：Castpr淘汰淘汰负面筛选在体外和体内治疗人类癌症中的CDKs抑制剂和二甲双胍之间的协同作用
- 作者：Yarui Ma;Qing Zhu;Junbo Liang;Yifei Li;Mo Li;Ying Zhang;Xiaobing Wang;Yixin Zeng;Yuchen Jiao
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
81.Comparison of nonhuman primates identified the suitable model for COVID-19

机译：非人类灵长类动物的比较确定了Covid-19的合适模型
- 作者：Shuaiyao Lu;Yuan Zhao;Wenhai Yu;Yun Yang;Jiahong Gao;Junbin Wang;Dexuan Kuang;Mengli Yang;Jing Yang;Chunxia Ma;Jingwen Xu;Xingli Qian;Haiyan Li;Siwen Zhao;Jingmei Li;Haixuan Wang;Haiting Long;Jingxian Zhou;Fangyu Luo;Kaiyun Ding;Daoju Wu;Yong Zhang;Yinliang Dong;Yuqin Liu;Yinqiu Zheng;Xiaochen Lin;Li Jiao;Huanying Zheng;Qing Dai;Qiangming Sun;Yunzhang Hu;Changwen Ke;Hongqi Liu;Xiaozhong Peng
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
82.Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals

机译：对SARS-COV-2感染的适应性免疫反应严重与轻度个体
- 作者：Fan Zhang;Rui Gan;Ziqi Zhen;Xiaoli Hu;Xiang Li;Fengxia Zhou;Ying Liu;Chuangeng Chen;Shuangyu Xie;Bailing Zhang;Xiaoke Wu;Zhiwei Huang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
83.Membranous NOX5-derived ROS oxidizes and activates local Src to promote malignancy of tumor cells

机译：膜NOx5衍生的ROS氧化并激活局部SRC以促进肿瘤细胞的恶性肿瘤
- 作者：Jie Chen;Yan Wang;Weimin Zhang;Di Zhao;Lingyuan Zhang;Jiawen Fan;Jinting Li;Qimin Zhan
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
84.Step further towards targeted senolytic therapy: therapeutic potential of uPAR-CAR T cells for senescence-related diseases

机译：进一步朝向靶向森思疗法的步骤：用于衰老相关疾病的UPAR-CAR T细胞的治疗潜力
- 作者：Yujia Huang;Tao Liu
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
85.The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis

机译：盐诱导激酶（SIK）在代谢稳态和肿瘤发生中的效力作用
- 作者：Zicheng Sun;Qiwei Jiang;Jie Li;Jianping Guo
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
86.An extracellular matrix paradox in myocardial scar formation

机译：心肌瘢痕形成的细胞外基质悖论
- 作者：Sangkyun Cho;David T. Paik;Joseph C. Wu
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
87.Targeting chemokines/chemokine receptors: a promising strategy for enhancing the immunotherapy of pancreatic ductal adenocarcinoma

机译：靶向趋化因子/趋化因子受体：提高胰腺导管腺癌免疫疗法的有希望的策略
- 作者：Ruining Gong;He Ren
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
88.CD146, from a melanoma cell adhesion molecule to a signaling receptor

机译：CD146，从黑色素瘤细胞粘附分子到信号受体
- 作者：Zhaoqing Wang;Qingji Xu;Nengwei Zhang;Xuemei Du;Guangzhong Xu;Xiyun Yan
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
89.Targeted therapy for hepatocellular carcinoma

机译：针对肝细胞癌的靶向治疗
- 作者：Ao Huang;Xin-Rong Yang;Wen-Yuan Chung;Ashley R. Dennison;Jian Zhou
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
90.The AKT-independent MET–V-ATPase–MTOR axis suppresses liver cancer vaccination

机译：Akt-romedy的Met-V-ATPase-MTOR轴抑制肝癌疫苗接种
- 作者：Xing Huang;Xingyuan Xu;Xun Wang;Tianyu Tang;Enliang Li;Xiaozhen Zhang;Jian Xu;Hang Shen;Chengxiang Guo;Tao Xu;Jianhong Ren;Xueli Bai;Tingbo Liang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
91.Exosomes: key players in cancer and potential therapeutic strategy

机译：外来肌肉：癌症中的关键球员和潜在的治疗策略
- 作者：Jie Dai;Yangzhou Su;Suye Zhong;Li Cong;Bang Liu;Junjun Yang;Yongguang Tao;Zuping He;Chao Chen;Yiqun Jiang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
92.Application of exosomes as liquid biopsy in clinical diagnosis

机译：外来体在临床诊断中的液体活检应用
- 作者：Biting Zhou;Kailun Xu;Xi Zheng;Ting Chen;Jian Wang;Yongmao Song;Yingkuan Shao;Shu Zheng
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
93.The role of histone methylation in the development of digestive cancers: a potential direction for cancer management

机译：组蛋白甲基化在消化癌症发展中的作用：癌症管理的潜在方向
- 作者：Yuan Chen;Bo Ren;Jinshou Yang;Huanyu Wang;Gang Yang;Ruiyuan Xu;Lei You;Yupei Zhao
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
94.Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms

机译：Auranofin通过独特的机制减轻全身铁过载并诱导恶性凋亡
- 作者：Lei Yang;Hao Wang;Xiang Yang;Qian Wu;Peng An;Xi Jin;Weiwei Liu;Xin Huang;Yuzhu Li;Shiyu Yan;Shuying Shen;Tingbo Liang;Junxia Min;Fudi Wang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
95.Microbiome harbored within tumors: a new chance to revisit our understanding of cancer pathogenesis and treatment

机译：微生物组在肿瘤内遭到困境：重新审视我们对癌症发病机制和治疗的理解的新机会
- 作者：Kunming Zhao;Ying Hu
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
96.The model of cytokine release syndrome in CAR T-cell treatment for B-cell non-Hodgkin lymphoma

机译：B细胞非霍奇金淋巴瘤汽车T细胞治疗中细胞因子释放综合征模型
- 作者：Jianshu Wei;Yang Liu;Chunmeng Wang;Yajing Zhang;Chuan Tong;Guanghai Dai;Wei Wang;John E. J. Rasko;J. Joseph Melenhorst;Wenbin Qian;Aibin Liang;Weidong Han
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
97.Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence

机译：妇科癌症的有针对性的疗法：对临床证据进行全面审查
- 作者：Qiao Wang;Hongling Peng;Xiaorong Qi;Min Wu;Xia Zhao
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
98.Functional characterization of SOX2 as an anticancer target

机译：SOX2作为抗癌目标的功能表征
- 作者：Shizhen Zhang;Xiufang Xiong;Yi Sun
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
99.COVID-19: immunopathogenesis and Immunotherapeutics

机译：Covid-19：免疫病理学和免疫治疗
- 作者：Li Yang;Shasha Liu;Jinyan Liu;Zhixin Zhang;Xiaochun Wan;Bo Huang;Youhai Chen;Yi Zhang
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期
100.ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy

机译：Aldh2通过CGAS-Sting-TBK1介导的MITOCHY促进褪黑激素诱导的褪黑激素诱导的保护保护诱导的心脏异常
- 作者：Shuyi Wang;Lin Wang;Xing Qin;Subat Turdi;Dongdong Sun;Bruce Culver;Russel J. Reiter;Xiaoming Wang;Hao Zhou;Jun Ren
- 期刊名称：《Signal transduction and targeted therapy.》 | 2020年第1期

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