Linkage of the Steroid Sulfatase Gene to the Sex-Reversed Mutation in the Mouse

摘要

Dosage studies and the inheritance pattern of the gene for steroid sulfatase ( Sts ) in the mouse have previously provided indirect evidence for a functional Y -linked allele which recombines obligatorily with its X -linked allele in male meiosis. In this study, we have investigated the linkage relationship of Sts and the sex-reversed mutation ( Sxr ), a gene which is known to reside in the pairing region of the Y chromosome. The results clearly demonstrate that Sxr and Sts are linked in a region of obligatory recombination and Sts maps proximal to Sxr with most recombinants occurring proximal to the two genes.