Role of (p)ppGpp in Biofilm Formation by Enterococcus faecalis

摘要

Enterococcus faecalis strain OG1RF and its (p)ppGpp-deficient Δ relA , Δ relQ , and Δ relA Δ relQ mutants were grown in biofilms and evaluated for growth profiles, biofilm morphology, cell viability, and proteolytic activity. E. faecalis lacking (p)ppGpp had a diminished capacity to sustain biofilm formation over an extended period of time and expressed abundant proteolytic activity.