Comparative Antimicrobial Activities of some Monosaccharide and Disaccharide Acetates

摘要

Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 A number of furanose ( 2 , 4 ) and pyranose ( 5 , 7 , 9 , 11 , 13 ) acetates were prepared by direct acetylation method. For comparative antimicrobial studies sucrose octaacetate ( 14 ) was also prepared. All the compounds ( 1 - 14 ) were screened for in vitro antibacterial activity against ten human pathogenic bacteria viz. Bacillus subtilis , Bacillus cereus , Bacillus megaterium , Staphylococcus aureus , Escherichia coli , INABA ET ( Vibrio ), Pseudomonas species, Salmonella paratyphi , Salmonella typhi and Shigella dysenteriae . These compounds were also screened for in vitro antifungal activity against four pathogenic fungi viz. Aspergillus niger, Alternaria alternata, Curvularia lunata and Fusarium equiseti . The study revealed that the pyranose acetate derivatives ( 5 , 7 , 9 , 11 , 13 ) are more prone towards antimicrobial functionality than those of the furanose acetates ( 2 , 4 ) and sucrose octaacetate ( 14 ).