Development of Poly(Vinyl Alcohol) Cryo-Systems with Medicines and Their Comparative Study of Antimicrobial Activity and Cytotoxicity

摘要

The aim of the work was to develop the poly(vinyl alcohol) cryogel systems (PVA_(GS)) with plant extracts (PPe) and simple conventional medicine (Cm), and compare their antimicrobial activity, biocompatibility and cytotoxicity. The stability of gels systems with and without medicines was determined, the gel content and swelling degree were calculated. In vitro studies of PVA_(GS), with and without medicines, microbial contamination risk - the colonization level of the microorganisms and adhesion activity for the use of gel materials for the wound care were detected. PVA_(GS) biocompatibility and cytotoxic properties were examined on cell lines.