Quercetin Does Not Alter Erythrocyte Osmotic Fragility in Female, Sprague Dawley Rats Fed a High-fructose, High-cholesterol Diet

摘要

Background and Objectives: Increased dietary cholesterol and fructose intake is associated with increased erythrocyte membrane rigidity and damage as a result of lipid peroxides, leading to increased erythrocyte osmotic fragility. Flavonoids possess anti-oxidant properties associated with their ability to stabilize cell membranes. The current study investigated the effects of a high-fructose, high-cholesterol diet, together with quercetin (a flavonoid), on erythrocyte osmotic fragility and erythrocyte indices of female Sprague Dawley rats. Methods and Materials: Rats received their respective diets and drinking solutions ad libitum for 8 weeks, following which blood samples were collected and analysed. Results: No significant differences (p0.05) in terminal body mass was observed between groups. Serum cholesterol concentrations were increased (pConclusion: Feeding rats a high-fructose, high-cholesterol diet for 8 weeks resulted in hypercholesterolemia but had no effect on erythrocyte osmotic fragility or serum triglyceride concentrations. The administration of quercetin had no effect on the parameters assessed.