Investigation of an Amylase Inhibitor on Human Glucose Absorption after Starch Consumption

摘要

Inhibition of carbohydrate metabolism or absorption can decrease calorie intake to promote weight lossand combat obesity. It is also a mechanism for reducing hyperglycemia in diabetic subjects. A concentrated northernkidney bean extract was found to be an effective in vitro amylase inhibitor, thus potentially affecting the absorption ofstarch carbohydrates. This product was tested in two single dose human studies. Eleven fasting subjects were given 4slices of white bread and 42 g of margarine with or without 1.5 g of bean extract. Absorption as measured by the areaunder the plasma glucose-time curve was inhibited 66%. A full meal study with 7 subjects and 0.75 g of extract caused anon-significant 28-41% reduction in absorption. There was a dose-response decrease in glucose absorption by the extract.The bean extract has in vivo efficacy for inhibition of starch absorption and may prove beneficial in weight reduction inindividuals consuming large amounts of starch. It also may inhibit starch-induced hyperglycemia in normal and diabeticsubjects.