A neonate with hand, foot, and mouth disease complicated with brainstem encephalitis and pulmonary edema: A complete recovery

摘要

Hand, foot, and mouth disease (HFMD) with serious complications and fatal cases have been reported over the last decade worldwide. The authors report a rare case of HFMD in a neonate complicated with brainstem encephalitis and pulmonary edema. She had fever, lethargy, dyspnea. Physical examination revealed shock signs, fine rales on both lungs, absent Moro reflex. The patient had a rapidly progressive course with seizures, coma, no spontaneous breathing, chemosis. There were some vesicles on left sole and red maculopapular rashes on perianal skin. She had a history of exposure to HFMD. Fecal sample was positive for EV71 RNA by real-time PCR. Chest X-rays showed bilateral pulmonary infiltrates. MRI of the brain showed significant hypointensity in the brainstem on T1WI and hyperintensity on T2WI. She recovered well. This case highlights severe HFMD in neonates is rare. Medical history and physical examination are important in making diagnosis.doi: http://dx.doi.org/10.12669/pjms.304.4528How to cite this:Guo SJ, Wang DX, Dai CL, Wu H. A neonate with hand, foot, and mouth disease complicated with brainstem encephalitis and pulmonary edema: A complete recovery. Pak J Med Sci 2014;30(4):917-919. doi: http://dx.doi.org/10.12669/pjms.304.4528This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.