A 2045/KYRGYZSTAN/ 2007 STRAIN OF FOOT-AND-MOUTH DISEASE VIRUS Aphtae epizooticae TYPE A FOR ANTIGENIC AND IMMUNOGENIC PERFORMANCE CONTROL OF FOOT-AND-MOUTH DISEASE VACCINES AND FOR PRODUCTION OF BIOPREPARATIONS FOR DIAGNOSIS AND SPECIFIC PREVENTION OF FOOT-AND-MOUTH DISEASE TYPE A

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to veterinary virology and biotechnology, as well as the foot-and-mouth disease virus Aphtae epizooticae type A Picornaviridae, genus Aphtovirus, which is deposited in the Russian State Centre for Quality and Standardisation of Veterinary Drugs and Feed under registration number A No.2045/Kyrgyzstan/2007 - DEP. The disclosed strain is reproduced in a monolayer swine kidney cell culture, passaged Siberian mountain goat kidney cell cultures (PSGK-30), VHK-21 and IB-RS-2. After 18-24 hours of incubation, virus yield in said cell cultures reaches 6.0-7.5 Ig TCD₅₀/cm³. For multiplicity of infection (1-10 TCD/cell), the strain causes CPD after 5 hours, while preserving the initial characteristics when passaging in cell cutures for 10 passages.;EFFECT: disclosed strain can be used to control antigenic and immunogenic performance of foot-and-mouth disease vaccines and to produce biopreparations for diagnosis and specific prevention of foot-and-mouth disease type A.;6 cl, 1 dwg, 10 tbl, 12 ex