Clinical characteristics and treatment outcome of patients with isochromosome 17q (i17q) abnormality and myeloid neoplasms: A single center experience

摘要

Isochromosome 17q (i17q) is a commonly encountered chromosomal abnormality in myeloid neoplasms (MN) where there is a loss of17p and duplication of 17q – leading to a single copy of 17p and threecopies of 17q. It is found most commonly in combination with otherchromosomal abnormalities (complex cytogenetics) and rarely as a solemutation. Isochromosome 17q is seen in a variety of disorders such asPhiladelphia positive (Ph+ ) Chronic Myeloid Leukemia (CML), AcuteMyeloid Leukemia (AML), Hodgkin and non-Hodgkin lymphomas andmyeloproliferative neoplasms (MPN) including MDS/MPN overlapsyndromes. It is considered to be associated with poor prognosis andmay have unique clinicopathological features. [1,2].