Proceedings of the 23rd International Stroke Genetics Consortium Workshop: Kyoto, Japan

摘要

Objective To introduce possibly useful brain imaging phenotypes in UK Biobank. Background UK Biobank recruited about 500,000 community-dwelling participants aged 40–69 years across Great Britain between 2006 and 2010. Since 2014, a subset of participants started to acquire imaging assessment and ～10,000 of brain MRI, including T1-weighted structural, resting-state functional, task functional, T2-weighted FLAIR structural, diffusion, and susceptibility-weighted structural imaging, have been collected so far. Design/Methods Details of the brain MRI image acquisition are available online. As an example of brain MRI results, we showed differences in brain volume and white matter microstructures, which were derived from T1-weighted structural and diffusion imaging, respectively, between hypertensives (either SBP more or equal 140 mm Hg, DBP more or equal 90 mm Hg, or antihypertensives) and non-hypertensives (N = 1,559 each) and between pre-hypertensives (SBP 120–139 and DBP 80–89 mm Hg) and normotensives (SBP 120 mm Hg and DBP 80 mm Hg) (N = 694 each). Results Hypertensives showed lower hippocampal volume, lower axonal density and higher periaxonal water in several white matter tracts including the superior longitudinal fasciculus (red arrows) and the superior thalamic radiation (blue arrows) relative to non-hypertensives. The periaxonal water difference in the superior longitudinal fasciculus and the superior thalamic radiation (orange and light blue arrows) were found also between pre-hypertensives and normotensives. Conclusions Brain imaging phenotypes in UK Biobank provide useful endophenotypes for late life diseases.