: STABILIZED PHARMACEUTICAL COMPOSITIONS CONTAINING CALCIUM CHANNEL BLOCKERS INTERNATIONAL CLASSIFICATION : A61K 31/4422, 31/4427, 31/4439, 31/444, C07D 211/90, 211/92, C07F 9/59 PRIORITY DOCUMENT NO : 2000-108850 PRIORITY DATE : 11/04/2000 NAME OF PRIORITY COUNTRY : JAPAN INTERNATIONAL APPLICATION NO AND FILING DATE: : PCT/JP01/03087 amp; 10/04/2001 INTERNATIONAL PUBLICATION NO : WO 01/76598 PATENT OF ADDITION TO APPLICATION NO : NA FILED ON : NA DIVISIONAL TO APPLICATION NO : NA FILED ON : NA

摘要

A pharmaceutical composition containing a calcium channel blocker and exhibiting excellent storage stability, which comprises a calcium channel blocker of general formula (A) or a pharmacologically acceptable salt thereof and a pharmacologically acceptable alkaline medium capable of imparting a pH of 8 or higher to an aqueous solution or dispersion of the composition wherein R1 is optionally substituted C1-4 alkyl, amino, or cyano; R2 is optionally substituted C1-4 alkyl, substituted C3-4 alkenyl, or substituted 4- to 6-membered cyclic amino; R3 is substituted phenyl; R4 is optionally substituted C1-4 alkoxycarbonyl, 1,3,2- phosphorinan-2-yl, or 5,5-dimethyl-1,3,2-phosphorinan-2-yl; and R5 is C1-4 alkyl (FIG.) NIL