Class I HLA in patients suffering from tuberculosis - population analysis

摘要

The aim of the present study was the analysis of the relation between the incidence of tuberculosis and particular class I HLA among patients of hospitals in Gdańsk, Gdynia and Sopot. 115 patients with active tuberculosis were included in the examination of HLA from A, B, C locus. The diagnosis of tuberculosis was confirmed bacteriologically by the detection of Mycobacterium tuberculosis in sputum cultures. The control group consisted of 100 healthy, unrelated adults. The examination of class I antigens was performed according to microlymphocytotoxic NIH test by Terasaka. χ2 test was used for statistical analysis with the confidence level of p0.05, with the use of Yates' modification. The relative risk was calculated according to Woolf's method. The significantly increased value of the test for HLA-B62(15) (χ2=4.1; p0.05; RR=2.85) and HLA-Cw5 (χ2=3.86; p0.05; RR=6.72) was found in tuberculosis on the basis of our results. However we found significantly decreased values of χ2 test among patients suffering from tuberculosis with relative risk RR1 for antigens: HLA-A2 (χ2&eguals;6.8; p0.001), -A10 (χ2=72.45; p0.0001), -A26 (10) (χ=4.03; p0.05), -A11 (χ2=4.36; p0.05), -B40 (χ2=25.4; p0.0001), -B7 (χ2=4.75; p0.05), -Cw1 (χ2=4.1; p0.05). On the basis of these results it was concluded that: 1. In the population of patients suffering from tuberculosis, living in the area of North Poland antigens HLA-62(15) and HLA-Cw5 were found significantly more frequently in comparison with control group of healthy people. 2. In the examined group of patients antigens HLA-A2, -A26(10), -A11, -B7, -B40, -Cw1 were found significantly less frequently in comparison with the control group.