Objective: The objective of present study was to determine the optimum gas forming agent concentration to enhance the floating ability and drug release pattern of floating hydrogels by using factorial design. Methods : In this article calcium carbonates as gas forming agents was synthesized in modified floating kappa carrageenan hydrogels. Ranitidine Hydrochloride was used as drug. 3 2 full factorial design was utilized for the optimization of gas forming agents. Polymer ratio (X 1 ) and calcium carbonates concentration (X 2 ) were used as independent variables. The floating hydrogels were characterized and the results obtained are swelling ratio study, drug entrapment efficiency, floating lag time and cumulative drug release. Results : From the factorial batches, it was observed that formulation containing 0.5% of calcium carbonates with 80:20 ?C: NaCMC showed the optimum floating properties, swelling ratio, drug entrapment efficiency and cumulative drug release. Conclusion : Thus, formulation containing 0.5% of calcium carbonates with 80:20 ?C:NaCMC appear to be a potential approach to develop sustains drug release in gastrointestinal condition. Keywords : Floating hydrogels, Calcium carbonates, Kappa carrageenan, Sodium salt of carbomethylcellulose, Ranitidine hydrochloride, Optimization, Factorial design.
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