Inulin, Fructooligosaccharide and Lactobacillus acidophilus Affects Body Weight Gain and Blood Metabolites in Polycystic Ovarian Syndrome Rats

摘要

Prebiotics and probiotics have the potential to be an appropriate treatment of polycystic ovarian syndrome (PCOS) as they target the proposed initial pathological consequences in this syndrome. Present study of 16 weeks (involving 6 weeks for adjustment period and 10 weeks for collection period) was carried out to investigate in vivo potential effects of prebiotics and probiotic in PCOS induced female Wistar rats. Forty-five female rats were randomly separated in 5 groups (9 rats/group) and alloted names to diets viz., NC (Negative Control), PC (Positive control), I5 (inulin 5% w/w), F5 (fructooligosaccharide 5% w/w) and L1 (1% Lactobacillus acidophilus w/w about 1 × 10 10 CFU/g). All rats were PCOS induced except rats of NC group. Rats were offered water and feed ad labitum. Body weights and blood glucose were recorded weekly. At the end of tenth week of collection period all rats were bled to collect blood samples for analyzing lipid profile. At 8 th , 9 th and 10 th week of trial the dietary treatments significantly (P < 0.05) reduced the weight of the PCOS induced rats as compare to PC (P < 0.05). Similarly, at 6 th , 7 th , 8 th , 9 th , and 10 th week dietary treatments decreased blood glucose levels of PCOS induced rats as compare to PC (P < 0.05). In case of lipid profile, dietary treatments reduced the overall level of cholesterol, triglycerides and low-density lipoproteins in PCOS rats as compare to PC (P < 0.05). In conclusion, prebiotics and probiotics reduce body weight, blood glucose and improve lipid profile. Therefore, addition of prebiotics and probiotics could be novel approach to control PCOS.