POSITIVE IMPACT OF ORAL CONTRACEPTIVE USE ON WHOLE BLOOD PROFILE IN POLYCYSTIC OVARIAN SYNDROME

摘要

Drospirenone (DRSP) combined with ethinyl estradiol (EE) is commonly prescribed oral contraceptive pills (OCP) (1) and related to a 6.3-fold increased risk of venous thromboembolism (VTE) when compared to non-users (2). DRSP-containing OCPs are the first-line treatment option for polycystic ovarian syndrome (PCOS)(3), a predisposing condition for VTE. We examined the influence of an EE and DRSP-containing OCP on the viscoelasticity of whole blood clot formation as well as morphological characteristics of red blood cells of a female with PCOS compared to a healthy female.