Optimization of ultrasonic-assisted extraction of glycyrrhizic acid from licorice using response surface methodology

摘要

Purpose: The present study optimized the ultrasonicassistedextraction conditions to maximize the glycyrrhizicacid of extracts from licorice.Methods: Optimal conditions with regard to extractiontemperature (X1), extraction time (X2) and methanolconcentration (X3) were identified using response surfacemethodology (RSM). A central composite design (CCD) wasused for experimental design and analysis of the results toobtain the optimal processing parameters.