Antimicrobial, cytotoxic and antioxidant activity of methanolic extract of Glycyrrhiza glabra

摘要

The present study was undertaken to explore the free radical scavenging, antimicrobial andcytotoxic activity of the methanolic extract of Glycyrrhiza glabra (Fabaceae) using DPPH, discdiffusion and brine shrimp lethality bioassay methods respectively. Different degrees of effect wasnoticed incase of different methods of study. In antimicrobial screening, G. glabra showed potentantimicrobial activity against almost all the test organisms except Pseudomonas aeruginosa. Itexhibited highest sensitivity against Staphylococcus aureus with the zone of inhibition 22 mm.The extract possessed potent cytotoxic activity having LC 50 value of 0.771μg/ml. On the otherhand, the free radical scavenging activity was found moderate having IC 50 value of 87.152 μg/ml.