Relapsed, refractory peripheral T-cell lymphoma not otherwise specified successfully treated with allogeneic haematopoietic stem cell transplantation

摘要

Peripheral T-cell lymphoma (PTCL) is a rare haematological malignancy accounting for 3.7% of all lymphomas and 10-15% of all non-Hodgkin lymphomas (NHL)[1,2]. Peripheral T-cell lymphoma not otherwise specified(PTCL, NOS) is the commonest subtype of PTCL.However, its’ prevalence is lower in Asia than in the West[3]. Only 11 cases of T-cell lymphoma, NOS werereported in Sri Lanka in 2010 [4]. However, PTCL, NOSsubtype is not mentioned in this report. PTCL, NOS is ahighly aggressive lymphoma notorious for chemo-refractoriness and frequent relapses. High-dose chemotherapywith autologous stem cell transplantation is incorporatedin to primary therapy for young fit patients but remainsineffective for most and has not been tested in a randomized study [5]. Allogeneic haematopoietic stem celltransplantation (allo-HSCT) may offer a potential cure forthese patients though the optimal type and timing oftransplantation remain to be defined [6].