EVI1 expression in childhood acute lymphoblastic leukaemia is not restricted to MLL and BCR/ABL rearrangements and is influenced by age

摘要

EVI1 is a transcriptional regulator with an important function in haematopoiesis and self-renewal. 1 Aberrant overexpression of EVI1 has been firmly established as one of the most adverse prognostic markers in acute myeloid leukaemia (AML), 2 implying that EVI1 is one of the most aggressive oncogenes in AML. Importantly, a recent report in Leukemia from Konantz et al. 3 suggests that EVI1 might also have a role in paediatric acute lymphoblastic leukaemia (ALL), where high expression confers apoptosis resistance, and possibly also an adverse prognosis.