CLASSIFICATION AND RISK-ASSIGNMENT OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKAEMIA (ALL) BY GENE EXPRESSION SIGNATURES

摘要

The present invention relates to methods of genetic analysis for the classification, diagnosis and prognosis of acute lymphoblastic leukemia (ALL). The invention provides a method for producing a classification scheme for childhood acute lymphoblastic leukaemia (ALL) comprising the steps of: a) providing a plurality of reference samples, said reference samples comprising cell samples from a plurality of reference subjects suffering from childhood ALL, with known class of childhood ALL, and optionally known prognosis; b) providing reference profiles by establishing a gene expression profile, matched with parameters for class, and optionally prognosis for each of said reference samples individually; and c) construction of a classifier based upon the gene expression profiles of said reference samples, according to a double-loop cross-validation procedure.