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CLASSIFICATION AND RISK-ASSIGNMENT OF CHILDHOOD ACUTE MYELOID LEUKAEMIA (AML) BY GENE EXPRESSION SIGNATURES
CLASSIFICATION AND RISK-ASSIGNMENT OF CHILDHOOD ACUTE MYELOID LEUKAEMIA (AML) BY GENE EXPRESSION SIGNATURES
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机译:基因表达签名对儿童急性髓性白血病(AML)的分类和风险分配
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摘要
The present invention relates to methods of genetic analysis for the classification, diagnosis and prognosis of acute myeloid leukemia (AML). The invention provides a method for producing a classification scheme for childhood acute myeloid leukaemia (AML) comprising the steps of: a) providing a plurality of reference samples, said reference samples comprising cell samples from a plurality of reference subjects suffering from childhood AML, with known class of childhood AML, and optionally known prognosis; b) providing reference profiles by establishing a gene expression profile, matched with parameters for class, and optionally prognosis for each of said reference samples individually; and c) construction of a classifier based upon the gene expression profiles of said reference samples, according to a double-loop cross- validation procedure.
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