Time From Human Immunodeficiency Virus Seroconversion to Reaching CD4+ Cell Count Thresholds 200, 350, and 500 Cells/mm3:n Assessment of Need Following Changes in Treatment Guidelines

摘要

Background. Recent updates of human immunodeficiency virus (HIV) treatment guidelines have raised the CD4+ cell count thresholds for antiretroviral therapy initiation from 350 to 500 cells/mm3 in the United States and from 200 to 350 cells/mm3 in mid- and low-income countries. Robust data of time from HIV seroconversion to CD4+ cell counts of 200, 350, and 500 cells/mm3 are lacking but are needed to inform health care planners of the likely impact and cost effectiveness of these and possible future changes in CD4+ cell count initiation threshold.