Short Communication: Factors Influencing Time to CD4+ T Cell Counts 200 Cells/mm3 in HIV-Infected Individuals with CD4+ T Cell 50 Cells/mm3 at the Time of Starting Combination Antiretroviral Therapy

摘要

We evaluated factors influencing time to CD4⁺ T cell counts >200 cells/mm³ in HIV-infected individuals with CD4⁺ T cell <50 cells/mm³ starting combination antiretroviral therapy (cART). We included a total of 29 patients on successful cART for more than 1 year. In a logistic regression model, higher pre-cART CD4⁺ T cell counts were significantly associated with shorter time to CD4⁺ T cell counts >200cells/mm³ in HIV-infected individuals with baseline CD4⁺ T cell <50 cells/mm³. In survival analysis, patients having higher pre-cART CD4⁺ T cell counts, especially 40–49 cells/mm³, were at significantly higher risk of achieving CD4⁺ T cell counts >200 cells/mm³.