Effects of antisense glutamic aciddecarboxylase oligodeoxynucleotide on epileptic rats induced by pentylenetetrazol

摘要

Conclusion The gene of GAD_67 may be an anti-seizure gene, which might inhibit epiliptiform discharge. The treatment of epilepsy by GAD_67 gene will have a bright future. Objective To investigate the effects of antisense glutamic acid decarboxylase(HAD_67)oligodeoxynucleo- Tide(ODN)on behavior, seizure threshold and Eeg of hippocampus in the epileptic rats induced by Pentylenetetrazol(PTZ). Methods A model of chronic epilepsy in rats was established by PTZ. The inhibition of GAD_67 mRNA Expression in hippocampus was selectively induced by antisense oligodeoxynucleotides of GAD_67.