PPARγ agonists inhibit angiogenesis by suppressing PKCα- and CREB-mediated COX-2 expression in the human endothelium

Egeria Scoditti; Marika Massaro; Maria Annunziata Carluccio; Alessandro Distante; Carlo Storelli; Raffaele De Caterina

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PPARγ agonists inhibit angiogenesis by suppressing PKCα- and CREB-mediated COX-2 expression in the human endothelium

机译：PPARγ激动剂通过抑制人内皮中PKCα和CREB介导的COX-2表达来抑制血管生成

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Aims The activation of peroxisome proliferator-activated receptor (PPAR)γ is known to inhibit angiogenesis. As a potential mechanism for this, we aimed at examining the effects of PPARγ agonists on the pro-angiogenic enzyme cyclooxygenase (COX)-2 in human endothelium.

机译：目的已知过氧化物酶体增殖物激活受体（PPAR）γ的激活可抑制血管生成。作为一种潜在的机制，我们旨在研究PPARγ激动剂对人内皮中促血管生成酶环氧合酶（COX）-2的作用。

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《Cardiovascular Research》 |2010年第2期|p.302-310|共9页
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Egeria Scoditti; Marika Massaro; Maria Annunziata Carluccio; Alessandro Distante; Carlo Storelli; Raffaele De Caterina;
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, University of Salento, ,Corresponding author. Tel: ,;

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1. PPARgamma agonists inhibit angiogenesis by suppressing PKCalpha- and CREB-mediated COX-2 expression in the human endothelium. [J] . Scoditti E, Massaro M, Carluccio MA, Cardiovascular Research . 2010,第2期

机译：PPARγ激动剂通过抑制人内皮中PKCalpha和CREB介导的COX-2表达来抑制血管生成。
2. The Effect of Biotinylated PAMAM G3 Dendrimers Conjugated with COX-2 Inhibitor (celecoxib) and PPARγ Agonist (Fmoc-L-Leucine) on Human Normal Fibroblasts, Immortalized Keratinocytes and Glioma Cells in Vitro [J] . ?ukasz Uram, Maria Misiorek, Monika Pichla, Molecules . 2019,第20期

机译：结合COX-2抑制剂（celecoxib）和PPARγ激动剂（Fmoc-L-亮氨酸）的生物素化PAMAM G3树状聚合物对人正常成纤维细胞，永生化角质形成细胞和神经胶质瘤细胞的影响
3. Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway [J] . Yulin Peng, Yan Wang, Ning Tang, Journal of experimental & clinical cancer research : . 2018,第1期

机译：穿心莲内酯通过抑制COX-2表达和通过使p300信号和VEGF通路失活来抑制血管生成来抑制乳腺癌
4. KG-135 Inhibits COX-2 Expression by Blocking the Activation of JNK and AP-1 in Phorbol Ester-Stimulated Human Breast Epithelial Cells [C] . SIN-AYE PARK, EUN-HEE KIM, HYE-KYUNG NA, Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：KG-135通过阻断由佛波酯刺激的人乳腺癌上皮细胞中的JNK和AP-1的活化来抑制COX-2的表达
5. Impact of nicotine and PPARδ-agonist on human mesenchymal stem cells [D] . Bhat, Samerna 2013

机译：尼古丁和PPARδ激动剂对人间充质干细胞的影响
6. The Effect of Biotinylated PAMAM G3 Dendrimers Conjugated with COX-2 Inhibitor (celecoxib) and PPARγ Agonist (Fmoc-L-Leucine) on Human Normal Fibroblasts Immortalized Keratinocytes and Glioma Cells in Vitro [O] . Łukasz Uram, Maria Misiorek, Monika Pichla, 2019

机译：结合COX-2抑制剂（celecoxib）和PPARγ激动剂（Fmoc-L-亮氨酸）的生物素化PAMAM G3树状聚合物对人正常成纤维细胞永生化角质形成细胞和神经胶质瘤细胞的影响
7. Peroxisome proliferator-activated receptory inhibits angiogenesis by suppressing creb-mediated cyclooxygenase-2 expression in human endothelium [O] . Scoditti Egeria, Massaro Marika, Carluccio Maria Annunziata, 2008

机译：过氧化物酶体增殖物激活的受体通过抑制人类内皮中Creb介导的环氧合酶2表达来抑制血管生成
8. Effect of COX-2 Inhibitors on the Aromatase Gene (CYP19) Expression in Human Breast Cancer [R] . Shapiro, C. L. 2006

机译：COX-2抑制剂对人乳腺癌芳香化酶基因（CYp19）表达的影响

PPARγ agonists inhibit angiogenesis by suppressing PKCα- and CREB-mediated COX-2 expression in the human endothelium

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