A limited sampling strategy to estimate individual pharmacokinetic parameters of methotrexate in children with acute lymphoblastic leukemia

Christine Piard; Fran?oise Bressolle; May Fakhoury; Daolun Zhang; Karina Yacouben; André Rieutord; Evelyne Jacqz-Aigrain

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A limited sampling strategy to estimate individual pharmacokinetic parameters of methotrexate in children with acute lymphoblastic leukemia

机译：评估甲氨蝶呤在急性淋巴细胞白血病儿童中个别药代动力学参数的有限采样策略

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摘要

The objectives of this study were to characterize the population pharmacokinetics of MTX in patients with acute lymphoblastic leukemia (ALL) with ages ranging from 2 to 16 years and to propose a limited sampling strategy to estimate individual pharmacokinetic parameters.

机译：这项研究的目的是表征年龄在2至16岁之间的急性淋巴细胞白血病（ALL）患者中MTX的总体药代动力学，并提出一种有限的采样策略来估计各个药代动力学参数。

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来源
《Cancer Chemotherapy and Pharmacology》 |2007年第4期|609-620|共12页
作者
Christine Piard; Fran?oise Bressolle; May Fakhoury; Daolun Zhang; Karina Yacouben; André Rieutord; Evelyne Jacqz-Aigrain;
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作者单位

Department of Paediatric Pharmacology and Pharmacogenetics Robert Debré Hospital Paris France;

Clinical Pharmacokinetic Laboratory Faculty of Pharmacy University Montpellier I 15 Avenue Ch. Flahault B.P. 14491 34093 Montpellier Cedex 5 France;

Department of Paediatric Pharmacology and Pharmacogenetics Robert Debré Hospital Paris France;

Department of Paediatric Pharmacology and Pharmacogenetics Robert Debré Hospital Paris France;

Department of Paediatric Immunohematology Robert Debré Hospital Paris France;

Department of Pharmacy Robert Debré Hospital Paris France;

Department of Paediatric Pharmacology and Pharmacogenetics Robert Debré Hospital Paris France;

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原文格式 PDF
正文语种 eng
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关键词
Methotrexate; Pharmacokinetics; Population approach; NONMEM; Lymphoblastic leukemia; Limited sampling strategy;

机译：甲氨蝶呤;药代动力学;人口方法;NONMEM;淋巴母细胞白血病;有限采样策略;

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专利

1. A limited sampling strategy to estimate individual pharmacokinetic parameters of methotrexate in children with acute lymphoblastic leukemia [J] . Christine Plard, Fran?oise Bressolle, May Fakhoury, Cancer Chemotherapy and Pharmacology . 2007,第4期

机译：评估甲氨蝶呤在急性淋巴细胞白血病儿童中个别药代动力学参数的有限采样策略
2. A limited sampling strategy for estimating individual pharmacokinetic parameters of coagulation factor VIII in patients with hemophilia A. [J] . Bolon-Larger M, Chamouard V, Bressolle F, Therapeutic Drug Monitoring . 2007,第1期

机译：评估A型血友病患者凝血因子VIII的个别药代动力学参数的有限采样策略。
3. A limited-sampling strategy to estimate individual pharmacokinetic parameters of vinorelbine in elderly patients with advanced metastatic cancer. [J] . Gauvin A, Pinguet F, Culine S, Anti-cancer drugs . 2002,第5期

机译：估计老年晚期转移性癌症患者中长春瑞滨个体药代动力学参数的有限采样策略。
4. Optimizing the Classification of Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia Samples using Artificial Neural Networks [C] . Nuannuan Zong, Malek Adjouadi, Melvin Ayala Annual Rocky Mountain Bioengineering Symposium . 2006

机译：利用人工神经网络优化急性淋巴细胞白血病和急性髓性白血病样品的分类
5. Volatile Biomarkers from Cultured Human Immune Cells, Cultured Human Acute Lymphoblastic Leukemia Cells and the Exhaled Breath of Patients with Acute Myelogenous Leukemia [D] . Umber, Brandon James 2012

机译：培养的人类免疫细胞，培养的人类急性淋巴细胞白血病细胞和急性粒细胞性白血病患者呼气中的挥发性生物标志物
6. Polymorphisms of SLC19A1 80 GA MTHFR 677 CT and Tandem TS Repeats Influence Pharmacokinetics Acute Liver Toxicity and Vomiting in Children With Acute Lymphoblastic Leukemia Treated With High Doses of Methotrexate [O] . Magdalena Cwiklinska, Malgorzata Czogala, Kinga Kwiecinska, 2020

机译：SLC19A1 80g AMTHFR 677 C T串联TS重复的多态性影响药代动力学急性肝脏毒性并用高剂量的甲氨蝶呤治疗的急性淋巴细胞白血病呕吐
7. A limited sampling strategy to estimate individual pharmacokinetic parameters of methotrexate in children with acute lymphoblastic leukemia [O] . Christine Plard, Françoise Bressolle, May Fakhoury, 2007

机译：有限的抽样策略，以估算急性淋巴细胞白血病儿童甲氨蝶呤的个体药代动力学参数

A limited sampling strategy to estimate individual pharmacokinetic parameters of methotrexate in children with acute lymphoblastic leukemia

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