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Treatment with a GLP-1 receptor agonist diminishes the decrease in free plasma leptin during maintenance of weight loss

机译：在维持体重减轻期间使用GLP-1受体激动剂进行治疗可减少血浆游离瘦素的减少

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Background:Recent studies indicate that glucagon-like peptide (GLP)-1 inhibits appetite in part through regulation of soluble leptin receptors. Thus, during weight loss maintenance, GLP-1 receptor agonist (GLP-1RA) administration may inhibit weight loss-induced increases in soluble leptin receptors thereby preserving free leptin levels and preventing weight regain.

机译：背景：最近的研究表明，胰高血糖素样肽（GLP）-1部分通过调节可溶性瘦素受体抑制食欲。因此，在维持体重减轻期间，GLP-1受体激动剂（GLP-1RA）的给药可抑制体重减轻引起的可溶性瘦素受体增加，从而保持游离瘦素水平并防止体重恢复。

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期刊名称 NPG Open Access
作者
E W Iepsen; J Lundgren; C Dirksen; J-EB Jensen; O Pedersen; T Hansen; S Madsbad; J J Holst; S S Torekov;
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年(卷),期 -1(39),5
年度 -1
页码 834–841
总页数 8
原文格式 PDF
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专利

1. Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice [J] . Katsunori Nonogaki, Takao Kaji Journal of diabetes research. . 2018,第5期

机译：Liraglutide，一种GLP-1受体激动剂，可降低下丘脑5-HT2A受体的表达，可降低食欲和体重，而与小鼠血清素合成无关
2. Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice [J] . Nonogaki Katsunori, Kaji Takao Journal of diabetes research. . 2018,第Pta1期

机译：Liraglutide，一种GLP-1受体激动剂，其降低下丘脑5-HT2A受体表达，可单独降低小鼠血清素合成的食欲和体重
3. Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice [J] . Katsunori Nonogaki, Takao Kaji International Journal of Experimental Diabetes Research: Experimental Diabesity Research . 2018,第1期

机译：Liraglutide，GLP-1受体激动剂降低下丘脑5-HT2A受体表达，可单独降低食欲和体重小鼠的血清素合成
4. Agonists and Partial Antagonists Acting on the Leptin - Leptin Receptor Interface [C] . Laszlo Otvos Jr, Marco Cassone, Marianna Terrasi American Peptide Symposium . 2009

机译：作用于瘦素 - 瘦素受体界面的激动剂和部分拮抗剂
5. Reduction of Angiotensin II Induced Hypertension and Cardiac Fibrosis with GLP-1 Receptor Agonist and DPP-4 Inhibitor via Decreasing NADPH Oxidase Expression [D] . Banks, Trenton Edward. 2020

机译：通过降低NADPH氧化酶表达，通过降低NADPH-1受体激动剂和DPP-4抑制剂减少血管紧张素II诱导的高血压和心肌纤维化
6. Protocol for a randomised controlled trial of the combined effects of the GLP-1 receptor agonist liraglutide and exercise on maintenance of weight loss and health after a very low-calorie diet [O] . Simon Birk Kjær Jensen, Julie Rehné Lundgren, Charlotte Janus, 2019

机译：低热量饮食后GLP-1受体激动剂利拉鲁肽和运动联合维持体重减轻和健康的随机对照试验方案
7. Treatment with a GLP-1 receptor agonist diminishes the decrease in free plasma leptin during maintenance of weight loss [O] . E W Iepsen, J Lundgren, C Dirksen, 2014

机译：用GLP-1受体激动剂治疗减少了在体重减轻期间减少游离等离子体瘦素的减少

Treatment with a GLP-1 receptor agonist diminishes the decrease in free plasma leptin during maintenance of weight loss

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