Determination of Glucose Concentration in Whole Blood using Fourier-Transform Infrared Spectroscopy

摘要

Fourier-transform infrared(FTIR) transmission spectroscopy has beenused for the determination of glucoseconcentrations in whole blood samples fromtwenty-eight patients. A four-vectorpartial least squares calibration model,using the spectral range 950–1200 cm^-1,yielded a standard error of prediction of0.59 mM for an independent test set. Forblood samples from a single patient, wefound that the glucose concentration wasproportional to the difference between thevalues of the second derivative spectrum at1082 cm^-1 and 1093 cm^-1, suggestingthat these two specific wavelengths can beused for determining glucose concentrationsin blood.