首页> 美国卫生研究院文献>BMJ Open >Renal replacement treatment initiation with twice-weekly versus thrice-weekly haemodialysis in patients with incident dialysis-dependent kidney disease: rationale and design of the TWOPLUS pilot clinical trial

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Renal replacement treatment initiation with twice-weekly versus thrice-weekly haemodialysis in patients with incident dialysis-dependent kidney disease: rationale and design of the TWOPLUS pilot clinical trial

机译：肾脏替代治疗患者与入射透析依赖性肾病患者的两次每周对每周血液透析发生同期：TwoPlus Pilot临床试验的理由和设计

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摘要

The optimal haemodialysis (HD) prescription—frequency and dose—for patients with incident dialysis-dependent kidney disease (DDKD) and substantial residual kidney function (RKF)—that is, renal urea clearance ≥2 mL/min/1.73 m2 and urine volume ≥500 mL/day—is not known. The aim of the present study is to test the feasibility and safety of a simple, reliable prescription of incremental HD in patients with incident DDKD and RKF.

机译：最佳血液透析（HD）处方频率和剂量为入射透析依赖性肾病（DDKD）和大量残留的肾功能（RKF） - 该方法，肾尿素清除≥2mL/ min / 1.73m2和尿量≥500毫升/天 - 尚不清楚。本研究的目的是测试入射DDKD和RKF患者的简单，可靠的增量HD的可行性和安全性。

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期刊名称 BMJ Open
作者
Mariana Murea; Shahriar Moossavi; Alison J Fletcher; Deanna N Jones; Hiba I Sheikh; Gregory Russell; Kamyar Kalantar-Zadeh;
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作者单位

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年(卷),期 2021(11),5
年度 2021
页码 e047596
总页数 11
原文格式 PDF
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机译：透析;结束阶段肾功能衰竭;肾和泌尿道疾病;

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专利

1. A randomized pilot study comparing graft-first to fistula-first strategies in older patients with incident end-stage kidney disease: Clinical rationale and study design [J] . Mariana Murea, Randolph L. Geary, Matthew S. Edwards, Contemporary Clinical Trials Communications . 2019,第2期

机译：一项随机性的先导研究比较了老年晚期终末期肾脏疾病患者的移植优先和瘘管优先策略：临床依据和研究设计
2. Renal replacement therapy in the ICU: comparison of clinical features and outcomes of patients with acute kidney injury and dialysis-dependent end-stage renal disease [J] . Akbas Turkay, Karakurt Sait, Tuglular Serhan Clinical and experimental nephrology . 2015,第4期

机译：ICU中的肾脏替代治疗：急性肾损伤和透析相关性终末期肾病患者的临床特征和结局比较
3. Renal replacement therapy in the ICU: comparison of clinical features and outcomes of patients with acute kidney injury and dialysis-dependent end-stage renal disease [J] . Akbas Turkay, Karakurt Sait, Tuglular Serhan Clinical and experimental nephrology . 2015,第4期

机译：ICU肾置换疗法：急性肾损伤患者临床特征和结果的比较和透析依赖性终末期肾病
4. Development and testing of prediction models for end stage kidney disease patient nonadherence to renal replacement treatment regimens utilizing big data and healthcare informatics [C] . Yue Jiao, Geary Dan, Chaudhuri Sheetal, IEEE International Conference on Bioinformatics and Biomedicine . 2015

机译：利用大数据和医疗信息学开发和测试终末期肾病患者不遵守肾脏替代治疗方案的预测模型
5. Randomized multicentre pilot study of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease: United Kingdom Heart and Renal Protection (HARP)- III—rationale trial design and baseline data [O] . PK Judge, R Haynes, WG Herrington, -1

机译：沙比特利/缬沙坦与厄贝沙坦在慢性肾脏疾病患者中的随机多中心先导研究：英国心脏和肾脏保护（HARP）-III—理据试验设计和基线数据
6. Renal replacement treatment initiation with twice-weekly versus thrice-weekly haemodialysis in patients with incident dialysis-dependent kidney disease: rationale and design of the TWOPLUS pilot clinical trial [O] . Mariana Murea, Shahriar Moossavi, Alison J Fletcher, 2021

机译：肾脏替代治疗患者与入射透析依赖性肾病患者的两次每周对每周血液透析发生同期：TwoPlus Pilot临床试验的理由和设计

Renal replacement treatment initiation with twice-weekly versus thrice-weekly haemodialysis in patients with incident dialysis-dependent kidney disease: rationale and design of the TWOPLUS pilot clinical trial

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