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Randomized multicentre pilot study of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease: United Kingdom Heart and Renal Protection (HARP)- III—rationale trial design and baseline data

机译：沙比特利/缬沙坦与厄贝沙坦在慢性肾脏疾病患者中的随机多中心先导研究：英国心脏和肾脏保护（HARP）-III—理据试验设计和基线数据

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BackgroundPatients with chronic kidney disease (CKD) are at risk of progression to end-stage renal disease and cardiovascular disease. Data from other populations and animal experiments suggest that neprilysin inhibition (which augments the natriuretic peptide system) may reduce these risks, but clinical trials among patients with CKD are required to test this hypothesis.

机译：背景患有慢性肾脏疾病（CKD）的患者有发展为晚期肾脏疾病和心血管疾病的风险。来自其他人群和动物实验的数据表明，抑制脑啡肽酶（可增强利钠肽系统）可以降低这些风险，但是需要在CKD患者中进行临床试验以验证这一假设。

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期刊名称 Nephrology Dialysis Transplantation
作者
PK Judge; R Haynes; WG Herrington; BC Storey; N Staplin; A Bethel; L Bowman; N Brunskill; P Cockwell; R Dayanandan; M Hill; PA Kalra; JJ McMurray; M Taal; DC Wheeler; MJ Landray; C Baigent; C Baigent; R Haynes; MJ Landray; R Dayanandan; A Baxter; N Staplin; A Bethel; L Bowman; N Brunskill; P Cockwell; WG Herrington; M Hill; PK Judge; PA Kalra; C Knott; JJ McMurray; K Murphy; M Taal; DC Wheeler; K Wheatley; J Emberson; C Tomson; P Roderick;
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年(卷),期 -1(32),12
年度 -1
页码 2043–2051
总页数 9
原文格式 PDF
正文语种
中图分类泌尿科学（泌尿生殖系疾病）;小儿泌尿科学;肾疾病;移植;
关键词
cardiovascular disease chronic kidney disease neprilysin progression;

机译：心血管疾病;慢性肾脏疾病;中性溶酶;进展;

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专利

1. Effects of Sacubitril/Valsartan Versus Irbesartan in Patients With Chronic Kidney Disease: A Randomized Double-Blind Trial [J] . Haynes Richard, Judge Parminder K., Staplin Natalie, Circulation: An Official Journal of the American Heart Association . 2018,第15期

机译：Sacubitril / Valsartan与厄贝沙坦对慢性肾病患者的影响：随机双盲试验
2. Efficacy and safety of sacubitril/valsartan (LCZ696) in Japanese patients with chronic heart failure and reduced ejection fraction: Rationale for and design of the randomized, double-blind PARALLEL-HF study [J] . Tsutsui Hiroyuki, Momomura Shinichi, Saito Yoshihiko, Journal of cardiology . 2017,第3a4期

机译：Sacubitril / Valsartan（LCZ696）在日本慢性心力衰竭患者中的疗效和安全性和减少射血分数：随机，双盲并行 - HF研究的理由和设计
3. Rationale, design, and baseline characteristics of the Study assessInG the morbidity-mortality beNefits of the If inhibitor ivabradine in patients with coronarY artery disease (SIGNIFY trial): A randomized, double-blind, placebo-controlled trial of ivabradine in patients with stable coronary artery disease without clinical heart failure [J] . FoxK., FordI., StegP.G., The American heart journal . 2013,第4期

机译：研究的基本原理，设计和基线特征评估了冠状动脉疾病患者中If抑制剂ivabradine的发病率-死亡率（SIGNIFY试验）：稳定冠心病患者使用ivabradine的随机，双盲，安慰剂对照试验没有临床心力衰竭的动脉疾病
4. The PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease trial: study design and baseline data for a multicentre randomized controlled trial [O] . Sharlene A Greenwood, Pelagia Koufaki, Jamie Macdonald, 2021

机译：细胞内锻炼的处方提高慢性肾病试验患者生活质量：多期式随机对照试验的研究设计和基线数据
5. Randomized multicentre pilot study of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease: United Kingdom Heart and Renal Protection (HARP)- III-rationale, trial design and baseline data. [O] . UK HARP-III Collaborative Group 2016

机译：沙比特比/缬沙坦与厄贝沙坦在慢性肾脏疾病患者中的随机多中心先导研究：英国心脏和肾脏保护（HARP）-III级标准，试验设计和基线数据。

Randomized multicentre pilot study of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease: United Kingdom Heart and Renal Protection (HARP)- III—rationale trial design and baseline data

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