In silico benchmarking of metagenomic tools for coding sequence detection reveals the limits of sensitivity and precision

摘要

Positive predictive value (PPV), sensitivity, and uniqueness of CDS calls by metagenomic analysis approaches. The positive predictive value (true positive over true positive plus false positive), sensitivity (true positive over true positive plus false negative) both overall and subsetted to CDS with 0–5x coverage, and uniqueness (true positive over true positive plus duplicates) on a per-CDS basis with different analysis approaches