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An IgG‐based bispecific antibody for improved dual targeting in PSMA‐positive cancer

机译：基于IgG的双特异性抗体用于改善PSMA阳性癌症的双重靶向

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期刊名称 EMBO Molecular Medicine
作者
Latifa Zekri; Fabian Vogt; Lukas Osburg; Stefanie Müller; Joseph Kauer; Timo Manz; Martin Pflügler; Andreas Maurer; Jonas S Heitmann; Ilona Hagelstein; Melanie Märklin; Sebastian Hörner; Tilmann Todenhöfer; Carsten Calaminus; Arnulf Stenzl; Bernd Pichler; Christian la Fougère; Marc A Schneider; Hans‐Georg Rammensee; Lars Zender; Bence Sipos; Helmut R Salih; Gundram Jung;
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作者单位

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年(卷),期 2021(13),2
年度 2021
页码 e11902
总页数 15
原文格式 PDF
正文语种
中图分类医学史;
关键词
bispecific antibody; immunotherapy; lung cancer; prostate cancer; PSMA;

机译：双特异性;免疫疗法;肺癌;前列腺癌;PSMA;

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专利

1. MOR209/ES414, a Novel Bispecific Antibody Targeting PSMA for the Treatment of Metastatic Castration-Resistant Prostate Cancer [J] . Hernandez-Hoyos Gabriela, Sewell Toddy, Bader Robert, Molecular cancer therapeutics . 2016,第9期

机译：MOR209 / ES414，靶向PSMA的新型双特异性抗体，用于治疗转移性去势抵抗性前列腺癌
2. Bispecific antibody complex pre-targeting and targeted delivery of polymer drug conjugates for imaging and therapy in dual human mammary cancer xenografts: Targeted polymer drug conjugates for cancer diagnosis and therapy [J] . KhawB.-A., GadaK.S., PatilV., European Journal of Nuclear Medicine and Molecular Imaging . 2014,第8期

机译：双特异性抗体复合物预靶向和靶向递送聚合物药物偶联物，用于双重人乳癌异种移植的成像和治疗：靶向聚合物药物偶联物，用于癌症的诊断和治疗
3. Residualizing iodine markedly improved tumor targeting using bispecific antibody-based pretargeting. [J] . van Schaijk FG, Broekema M, Oosterwijk E, The Journal of Nuclear Medicine . 2005,第6期

机译：使用基于双特异性抗体的预靶向作用，碘化残基可显着改善肿瘤靶向作用。
4. Dual-aptamer-based delivery vehicle of doxorubicin to both PSMA (+) and PSMA (-) prostate cancers [C] . Hunho Jo, Changill Ban Annual NSTI nanotechnology conference and expo . 2013

机译：基于双适体的阿霉素对PSMA（+）和PSMA（-）前列腺癌的传递载体
5. A novel approach to control and regulate the classical complement pathway: Highly specific inhibition of C1q globular head binding to human IgG using an engineered single chain antibody variable fragment; recruiting C1q to HER2 /neu positive cells using truncated bispecific antibodies [D] . Hwang, Hee Young 2007

机译：一种控制和调节经典补体途径的新方法：使用工程化的单链抗体可变片段高度特异性地抑制C1q球头与人IgG的结合；使用截短的双特异性抗体将C1q募集到HER2 / neu阳性细胞
6. Development of a Human IgG4 Bispecific Antibody for Dual Targeting of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) Cytokines [O] . Christoph Spiess, Jack Bevers III, Janet Jackman, 2013

机译：人IgG4双特异性抗体对白介素4（IL-4）和白介素13（IL-13）细胞因子双重靶向的开发。
7. MOR209/ES414, a Novel Bispecific Antibody Targeting PSMA for the Treatment of Metastatic Castration-Resistant Prostate Cancer [O] . Gabriela Hernandez-Hoyos, Toddy Sewell, Robert Bader, 2016

机译：Mor209 / ES414，一种新的双特异性抗体，用于治疗转移性阉割前列腺癌的PSMA
8. Cell Penetrating Bispecific Antibodies for Targeting Oncogenic Transcription Factors in Advanced Prostate Cancer. [R] . Lilly, M., Weisbart, R. 2016

机译：细胞穿透双特异性抗体靶向晚期前列腺癌的致癌转录因子。

An IgG‐based bispecific antibody for improved dual targeting in PSMA‐positive cancer

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