erbb-2 targeting agent and a bispecific antibody with antigen binding sites that bind an epitope to an extracellular part of erbb-2 and erbb-3 for treating an individual with an erbb-2, erbb-2 / positive tumor erbb-3

摘要

the invention relates, among others, to antibodies comprising a first antigen-binding site that binds erbb-2 and a second antigen-binding site that binds erbb-3. antibodies can typically reduce the ligand-induced erbb-3 receptor function in an erbb-2 and erbb-3 positive cell. methods for the treatment and use of antibodies in images and in the treatment of individuals with a positive tumor in erbb-2, erbb-3 or erbb-2/3 are also described.