Bispecific antibodies and ErbB- with antigen-binding sites that bind epitopes on the extracellular portion of ErbB-2 and ErbB-3 for the treatment of individuals with ErbB-2, ErbB-2 / ErbB-3 positive tumors 2 targeting agent

摘要

The invention relates in particular to an antibody comprising a first antigen-binding site which binds ErbB-2 and a second antigen-binding site which binds ErbB-3. The antibody can typically reduce the ligand-induced receptor function of ErbB3 on ErbB-2 and ErbB-3 positive cells. Also disclosed are methods of treating subjects with ErbB-2, ErbB-3, or ErbB-2 / 3 positive tumors, and methods of using the antibodies in imaging and treatment.