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EMBO Molecular Medicine

【机译】：EmBO分子医学

ISSN：-
出版周期：Twelve no. a year
语言：English

起始发布年份：2009
出版者：Chichester, West Sussex : Wiley-Blackwell
出版地：England

NLM刊名缩写：EMBO Mol Med

数据库引入：PubMed: v1n1, Apr. 2009-, PMC

MeSH词表主题词：Genetic Phenomena*; Medicine; Molecular Biology

备注：Description based on: 2009/1; title from cover. Latest issue consulted: 2009/1.展开▼

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1.Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease

机译：PDGF信号减弱可驱动新生儿慢性肺疾病中的肺泡和微血管缺陷
- 作者：Prajakta Oak;Tina Pritzke;Isabella Thiel;Markus Koschlig;Daphne S Mous;Anita Windhorst;Noopur Jain;Oliver Eickelberg;Kai Foerster;Andreas Schulze;Wolfgang Goepel;Tobias Reicherzer;Harald Ehrhardt;Robbert J Rottier;Peter Ahnert;Ludwig Gortner;Tushar J Desai;Anne Hilgendorff
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第11期
- bronchopulmonary dysplasia neonatal chronic lung disease PDGF‐Rα transforming growth factor‐β VEGF‐A;
2.Treatment of hypertension by increasing impaired endothelial TRPV4‐KCa2.3 interaction

机译：通过增加受损的内皮TRPV4-KCa2.3相互作用来治疗高血压
- 作者：Dongxu He;Qiongxi Pan;Zhen Chen;Chunyuan Sun;Peng Zhang;Aiqin Mao;Yaodan Zhu;Hongjuan Li;Chunxiao Lu;Mingxu Xie;Yin Zhou;Daoming Shen;Chunlei Tang;Zhenyu Yang;Jian Jin;Xiaoqiang Yao;Bernd Nilius;Xin Ma
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第11期
- artery endothelium hypertension KCa2.3 TRPV4;
3.Therapeutic gene editing in CD34+ hematopoietic progenitors from Fanconi anemia patients

机译：范可尼贫血患者CD34 +造血祖细胞中的治疗性基因编辑
- 作者：Begoña Diez;Pietro Genovese;Francisco J Roman‐Rodriguez;Lara Alvarez;Giulia Schiroli;Laura Ugalde;Sandra Rodriguez‐Perales;Julian Sevilla;Cristina Diaz de Heredia;Michael C Holmes;Angelo Lombardo;Luigi Naldini;Juan Antonio Bueren;Paula Rio
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第11期
- CD34sup+/sup cells Fanconi anemia gene editing hematopoietic stem and progenitor cells zinc finger nucleases;
4.Pathogen‐specific B‐cell receptors drive chronic lymphocytic leukemia by light‐chain‐dependent cross‐reaction with autoantigens

机译：病原体特异性B细胞受体通过与自身抗原的轻链依赖性交叉反应驱动慢性淋巴细胞性白血病
- 作者：Nereida Jiménez de Oya;Marco De Giovanni;Jessica Fioravanti;Rudolf Übelhart;Pietro Di Lucia;Amleto Fiocchi;Stefano Iacovelli;Dimitar G Efremov;Federico Caligaris‐Cappio;Hassan Jumaa;Paolo Ghia;Luca G Guidotti;Matteo Iannacone
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第11期
- autoantigens B‐cell receptor chronic lymphocytic leukemia infection light chains;
5.Sequence variation in PPP1R13L results in a novel form of cardio‐cutaneous syndrome

机译：PPP1R13L中的序列变异导致一种新型的心皮综合症
- 作者：Tzipora C Falik‐Zaccai;Yiftah Barsheshet;Hanna Mandel;Meital Segev;Avraham Lorber;Shachaf Gelberg;Limor Kalfon;Shani Ben Haroush;Adel Shalata;Liat Gelernter‐Yaniv;Sarah Chaim;Dorith Raviv Shay;Morad Khayat;Michal Werbner;Inbar Levi;Yishay Shoval;Galit Tal;Stavit Shalev;Eli Reuveni;Emily Avitan‐Hersh;Eugene Vlodavsky;Liat Appl‐Sarid;Dorit Goldsher;Reuven Bergman;Zvi Segal;Ora Bitterman‐Deutsch;Orly Avni
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第9期
6.An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function

机译：Alzheimer相关的TREM2变体出现在ADAM裂解位点并影响脱落和吞噬功能
- 作者：Kai Schlepckow;Gernot Kleinberger;Akio Fukumori;Regina Feederle;Stefan F Lichtenthaler;Harald Steiner;Christian Haass
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第10期
- Alzheimers disease neurodegeneration phagocytosis regulated intramembrane proteolysis TREM2;
7.TREM2 shedding by cleavage at the H157‐S158 bond is accelerated for the Alzheimers disease‐associated H157Y variant

机译：对于阿尔茨海默氏病相关的H157Y变异体通过在H157-S158键处的切割而断裂的TREM2加速了
- 作者：Peter Thornton;Jean Sevalle;Michael J Deery;Graham Fraser;Ye Zhou;Sara Ståhl;Elske H Franssen;Roger B Dodd;Seema Qamar;Beatriz Gomez Perez‐Nievas;Louise SC Nicol;Susanna Eketjäll;Jefferson Revell;Clare Jones;Andrew Billinton;Peter H St George‐Hyslop;Iain Chessell;Damian C Crowther
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第10期
- genetic risk microglia neurodegeneration neuroinflammation;
8.Genome editing for scalable production of alloantigen‐free lentiviral vectors for in vivo gene therapy

机译：基因组编辑可大规模生产用于体内基因治疗的无同种异源慢病毒载体
- 作者：Michela Milani;Andrea Annoni;Sara Bartolaccini;Mauro Biffi;Fabio Russo;Tiziano Di Tomaso;Andrea Raimondi;Johannes Lengler;Michael C Holmes;Friedrich Scheiflinger;Angelo Lombardo;Alessio Cantore;Luigi Naldini
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第11期
- gene therapy hemophilia lentiviral vectors MHC‐I stable producer cell line;
9.Thwarting endogenous stress: BRCA protects against aldehyde toxicity

机译：阻止内源性压力：BRCA防止醛毒性
- 作者：Arnab Ray Chaudhuri;André Nussenzweig
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第10期
10.Src‐dependent phosphorylation of μ‐opioid receptor at Tyr336 modulates opiate withdrawal

机译：Tyr336上μ阿片受体的Src依赖性磷酸化可调节阿片类药物戒断
- 作者：Lei Zhang;Cherkaouia Kibaly;Yu‐Jun Wang;Chi Xu;Kyu Young Song;Patrick W McGarrah;Horace H Loh;Jing‐Gen Liu;Ping‐Yee Law
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第11期
- lentivirus injection locus coeruleus naloxone‐precipitated opiate withdrawal opiate addiction Src‐mediated phosphorylation of MOR at Tyrsup336/sup;
11.One level up: abnormal proteolytic regulation of IGF activity plays a role in human pathophysiology

机译：向上升级：IGF活性的异常蛋白水解调节在人类病理生理中起作用
- 作者：Jesús Argente;Julie A Chowen;Luis A Pérez‐Jurado;Jan Frystyk;Claus Oxvig
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第10期
- IGF‐1 IGFBPs PAPP‐A PAPP‐A2 stanniocalcins (STC1 STC2);
12.β‐Klotho sustains postnatal GnRH biology and spins the thread of puberty

机译：β-Klotho维持产后GnRH生物学并扭转青春期的线
- 作者：Micheline Misrahi
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第10期
13.CDK6 protects epithelial ovarian cancer from platinum‐induced death via FOXO3 regulation

机译：CDK6通过FOXO3调节保护上皮性卵巢癌免于铂引起的死亡
- 作者：Alessandra DallAcqua;Maura Sonego;Ilenia Pellizzari;Ilenia Pellarin;Vincenzo Canzonieri;Sara DAndrea;Sara Benevol;Roberto Sorio;Giorgio Giorda;Daniela Califano;Marina Bagnoli;Loredana Militello;Delia Mezzanzanica;Gennaro Chiappetta;Joshua Armenia;Barbara Belletti;Monica Schiappacassi;Gustavo Baldassarre
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第10期
- ATR CDK6 FOXO3 ovarian cancer platinum sensitivity;
14.The cardiac microenvironment uses non‐canonical WNT signaling to activate monocytes after myocardial infarction

机译：心肌微环境在心肌梗死后使用非经典的WNT信号激活单核细胞
- 作者：Ingmar Sören Meyer;Andreas Jungmann;Christoph Dieterich;Min Zhang;Felix Lasitschka;Susann Werkmeister;Jan Haas;Oliver J Müller;Michael Boutros;Matthias Nahrendorf;Hugo A Katus;Stefan E Hardt;Florian Leuschner
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第9期
- inflammation monocytes myocardial infarction;
15.Clinical development of CAR T cells—challenges and opportunities in translating innovative treatment concepts

机译：CAR T细胞的临床开发-创新治疗概念的挑战和机遇
- 作者：Jessica Hartmann;Martina Schüßler‐Lenz;Attilio Bondanza;Christian J Buchholz
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第9期
- ATMPs cancer immunotherapy regulatory issues toxicities;
16.KLB encoding β‐Klotho is mutated in patients with congenital hypogonadotropic hypogonadism

机译：先天性性腺功能减退性腺功能减退症患者的KLB编码β-Klotho
- 作者：Cheng Xu;Andrea Messina;Emmanuel Somm;Hichem Miraoui;Tarja Kinnunen;James Acierno Jr;Nicolas J Niederländer;Justine Bouilly;Andrew A Dwyer;Yisrael Sidis;Daniele Cassatella;Gerasimos P Sykiotis;Richard Quinton;Christian De Geyter;Mirjam Dirlewanger;Valérie Schwitzgebel;Trevor R Cole;Andrew A Toogood;Jeremy MW Kirk;Lacey Plummer;Urs Albrecht;William F Crowley Jr;Moosa Mohammadi;Manuel Tena‐Sempere;Vincent Prevot;Nelly Pitteloud
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第10期
- beta‐klotho congenital hypogonadotropic hypogonadism fibroblast growth factor 21 fibroblast growth factor receptor 1;
17.Promoterless gene targeting without nucleases rescues lethality of a Crigler‐Najjar syndrome mouse model

机译：不含核酸酶的无启动子基因靶向挽救了Crigler-Najjar综合征小鼠模型的致死性
- 作者：Fabiola Porro;Giulia Bortolussi;Adi Barzel;Alessia De Caneva;Alessandra Iaconcig;Simone Vodret;Lorena Zentilin;Mark A Kay;Andrés F Muro
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第10期
- brain damage genetic liver disease homologous recombination hyperbilirubinemia kernicterus;
18.Going viral? Linking the etiology of human prostate cancer to the PCA3 long noncoding RNA and oncogenic viruses

机译：会流行吗？将人类前列腺癌的病因与PCA3长非编码RNA和致癌病毒联系起来
- 作者：Andre A Teixeira;Serena Marchiò;Emmanuel Dias‐Neto;Diana N Nunes;Israel T da Silva;Bryce Chackerian;Marc Barry;Richard C Lauer;Ricardo J Giordano;Richard L Sidman;Cosette M Wheeler;Webster K Cavenee;Renata Pasqualini;Wadih Arap
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第10期
19.Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis

机译：细胞内腺苷调节内皮细胞的表观遗传程序以促进血管生成
- 作者：Yiming Xu;Yong Wang;Siyuan Yan;Yaqi Zhou;Qiuhua Yang;Yue Pan;Xianqiu Zeng;Xiaofei An;Zhiping Liu;Lina Wang;Jiean Xu;Yapeng Cao;David J Fulton;Neal L Weintraub;Zsolt Bagi;Md Nasrul Hoda;Xiaoling Wang;Qinkai Li;Mei Hong;Xuejun Jiang;Detlev Boison;Christian Weber;Chaodong Wu;Yuqing Huo
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第9期
- adenosine adenosine kinase angiogenesis DNA methylation endothelial cells;
20.Spironolactone is an antagonist of NRG1‐ERBB4 signaling and schizophrenia‐relevant endophenotypes in mice

机译：螺内酯是小鼠NRG1-ERBB4信号传导和精神分裂症相关内表型的拮抗剂
- 作者：Michael C Wehr;Wilko Hinrichs;Magdalena M Brzózka;Tilmann Unterbarnscheidt;Alexander Herholt;Jan P Wintgens;Sergi Papiol;Maria Clara Soto‐Bernardini;Mykola Kravchenko;Mingyue Zhang;Klaus‐Armin Nave;Sven P Wichert;Peter Falkai;Weiqi Zhang;Markus H Schwab;Moritz J Rossner
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第10期
- drug repositioning NRG1‐ERBB4 schizophrenia spironolactone split TEV assay;
21.18F‐AV‐1451 and CSF T‐tau and P‐tau as biomarkers in Alzheimers disease

机译：18F‐AV‐1451和CSF T-tau和P-tau作为阿尔茨海默氏病的生物标志物
- 作者：Niklas Mattsson;Michael Schöll;Olof Strandberg;Ruben Smith;Sebastian Palmqvist;Philip S Insel;Douglas Hägerström;Tomas Ohlsson;Henrik Zetterberg;Jonas Jögi;Kaj Blennow;Oskar Hansson
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第9期
- Alzheimer biomarker cerebrospinal fluid positron emission tomography tau;
22.Rethinking the nonprofit foundation: an emerging niche in the rare disease ecosystem

机译：重新思考非营利基金会：稀有疾病生态系统中的新兴利基市场
- 作者：Annette C Bakker;Salvatore La Rosa
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第9期
23.BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

机译：BRCA1和BRCA2抑癌剂可预防内源性乙醛毒性
- 作者：Eliana MC Tacconi;Xianning Lai;Cecilia Folio;Manuela Porru;Gijs Zonderland;Sophie Badie;Johanna Michl;Irene Sechi;Mélanie Rogier;Verónica Matía García;Ankita Sati Batra;Oscar M Rueda;Peter Bouwman;Jos Jonkers;Anderson Ryan;Bernardo Reina‐San‐Martin;Joannie Hui;Nelson Tang;Alejandra Bruna;Annamaria Biroccio;Madalena Tarsounas
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第10期
- BRCA1 BRCA2 disulfiram acetaldehyde dehydrogenase DNA damage replication stress;
24.Oral administration of pyrophosphate inhibits connective tissue calcification

机译：口服焦磷酸盐抑制结缔组织钙化
- 作者：Dóra Dedinszki;Flóra Szeri;Eszter Kozák;Viola Pomozi;Natália Tőkési;Tamás Róbert Mezei;Kinga Merczel;Emmanuel Letavernier;Ellie Tang;Olivier Le Saux;Tamás Arányi;Koen van de Wetering;András Váradi
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第11期
- generalized arterial calcification of infancy oral pyrophosphate treatment pseudoxanthoma elasticum soft tissue calcification;
25.Phenotypic diversity drives paracrine drug tolerance

机译：表型多样性驱动旁分泌药物耐受
- 作者：Thomas Kuilman;Daniel S Peeper
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第8期
26.MG132‐induced progerin clearance is mediated by autophagy activation and splicing regulation

机译：MG132诱导的早老蛋白清除是由自噬激活和剪接调控介导的
- 作者：Karim Harhouri;Claire Navarro;Danielle Depetris;Marie‐Geneviève Mattei;Xavier Nissan;Pierre Cau;Annachiara De Sandre‐Giovannoli;Nicolas Lévy
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第9期
- autophagy MG132 PML‐NBs progerin splicing;
27.Macrophage deficiency of miR‐21 promotes apoptosis plaque necrosis and vascular inflammation during atherogenesis

机译：miR-21的巨噬细胞缺乏会促进动脉粥样硬化形成过程中的凋亡斑块坏死和血管炎症
- 作者：Alberto Canfrán‐Duque;Noemi Rotllan;Xinbo Zhang;Marta Fernández‐Fuertes;Cristina Ramírez‐Hidalgo;Elisa Araldi;Lidia Daimiel;Rebeca Busto;Carlos Fernández‐Hernando;Yajaira Suárez
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第9期
- apoptosis atherosclerosis macrophage polarization miRNA;
28.Orkambi® and amplifier co‐therapy improves function from a rare CFTR mutation in gene‐edited cells and patient tissue

机译：Orkambi®和放大器的联合疗法可改善基因编辑细胞和患者组织中罕见的CFTR突变从而改善功能
- 作者：Steven V Molinski;Saumel Ahmadi;Wan Ip;Hong Ouyang;Adriana Villella;John P Miller;Po‐Shun Lee;Kethika Kulleperuma;Kai Du;Michelle Di Paola;Paul DW Eckford;Onofrio Laselva;Ling Jun Huan;Leigh Wellhauser;Ellen Li;Peter N Ray;Régis Pomès;Theo J Moraes;Tanja Gonska;Felix Ratjen;Christine E Bear
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第9期
- amplifier c.3700 AG CFTR CRISPR/Cas9 cystic fibrosis;
29.Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells

机译：慢病毒载体逃避先天感知但在人类造血干细胞和祖细胞中触发p53
- 作者：Francesco Piras;Michela Riba;Carolina Petrillo;Dejan Lazarevic;Ivan Cuccovillo;Sara Bartolaccini;Elia Stupka;Bernhard Gentner;Davide Cittaro;Luigi Naldini;Anna Kajaste‐Rudnitski
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第9期
- gene therapy hematopoietic stem and progenitor cells innate sensing lentiviral vectors p53 signaling;
30.REST suppression mediates neural conversion of adult human fibroblasts via microRNA‐dependent and ‐independent pathways

机译：REST抑制通过microRNA依赖性和非依赖性途径介导成人成纤维细胞的神经转化
- 作者：Janelle Drouin‐Ouellet;Shong Lau;Per Ludvik Brattås;Daniella Rylander Ottosson;Karolina Pircs;Daniela A Grassi;Lucy M Collins;Romina Vuono;Annika Andersson Sjöland;Gunilla Westergren‐Thorsson;Caroline Graff;Lennart Minthon;Håkan Toresson;Roger A Barker;Johan Jakobsson;Malin Parmar
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第8期
- adult human dermal fibroblasts induced neurons microRNAs 9/9* and 124 RE1‐silencing transcription factor;
31.Oncolytic adenovirus expressing bispecific antibody targets T‐cell cytotoxicity in cancer biopsies

机译：表达双特异性抗体的溶瘤腺病毒靶向癌症活检中的T细胞细胞毒性
- 作者：Joshua D Freedman;Joachim Hagel;Eleanor M Scott;Ioannis Psallidas;Avinash Gupta;Laura Spiers;Paul Miller;Nikolaos Kanellakis;Rebecca Ashfield;Kerry D Fisher;Margaret R Duffy;Leonard W Seymour
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第8期
- adenovirus bispecific T‐cell engager BiTE oncolytic virus;
32.A normal genetic variation modulates synaptic MMP‐9 protein levels and the severity of schizophrenia symptoms

机译：正常的遗传变异可调节突触MMP-9蛋白水平和精神分裂症症状的严重程度
- 作者：Katarzyna Lepeta;Katarzyna J Purzycka;Katarzyna Pachulska‐Wieczorek;Marina Mitjans;Martin Begemann;Behnam Vafadari;Krystian Bijata;Ryszard W Adamiak;Hannelore Ehrenreich;Magdalena Dziembowska;Leszek Kaczmarek
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第8期
- dendritic spine morphology Fragile X mental retardation protein matrix metalloproteinase 9 phenotype‐based genetic association study single‐nucleotide polymorphism;
33.Calcineurin–NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy

机译：钙调神经磷酸酶– NFAT信号在髓样白细胞中：免疫抑制治疗的新前景和陷阱
- 作者：Kamila Bendickova;Federico Tidu;Jan Fric
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第8期
- cyclosporine A Dectin‐1 immunosuppression tacrolimus TLR4;
34.Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure

机译：靶向内皮素受体信号传导克服了异质性驱动的治疗失败
- 作者：Michael P Smith;Emily J Rowling;Zsofia Miskolczi;Jennifer Ferguson;Loredana Spoerri;Nikolas K Haass;Olivia Sloss;Sophie McEntegart;Imanol Arozarena;Alex von Kriegsheim;Javier Rodriguez;Holly Brunton;Jivko Kmarashev;Mitchell P Levesque;Reinhard Dummer;Dennie T Frederick;Miles C Andrews;Zachary A Cooper;Keith T Flaherty;Jennifer A Wargo;Claudia Wellbrock
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第8期
- AXL BRAF endothelin melanoma MITF;
35.Synergistic antibacterial effect of silver and ebselen against multidrug‐resistant Gram‐negative bacterial infections

机译：银和依布硒啉对多药耐药革兰氏阴性细菌感染的协同抗菌作用
- 作者：Lili Zou;Jun Lu;Jun Wang;Xiaoyuan Ren;Lanlan Zhang;Yu Gao;Martin E Rottenberg;Arne Holmgren
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第8期
- ebselen multidrug‐resistant Gram‐negative bacteria silver synergistic antibacterial effect thiol‐dependent redox system;
36.Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration

机译：γ-分泌酶的失活导致底物积累和非阿尔茨海默氏神经变性
- 作者：Hermien Acx;Lutgarde Serneels;Enrico Radaelli;Serge Muyldermans;Cécile Vincke;Elise Pepermans;Ulrike Müller;Lucía Chávez‐Gutiérrez;Bart De Strooper
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第8期
- Alzheimers disease Aph1 subunit selective inhibition side effects γ‐Secretase;
37.GDF15 is a heart‐derived hormone that regulates body growth

机译：GDF15是调节身体生长的源自心脏的激素
- 作者：Ting Wang;Jian Liu;Caitlin McDonald;Katherine Lupino;Xiandun Zhai;Benjamin J Wilkins;Hakon Hakonarson;Liming Pei
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第8期
- body growth failure to thrive GDF15 heart disease heart‐derived hormone;
38.MicroRNA dysregulation in cancer: diagnostics monitoring and therapeutics. A comprehensive review

机译：癌症中的MicroRNA失调：诊断监测和治疗。全面审查
- 作者：Marilena V Iorio;Carlo M Croce
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第6期
39.CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib

机译：CDK4磷酸化状态和相关的基因表达谱预测对palbociclib的敏感性
- 作者：Eric Raspé;Katia Coulonval;Jaime M Pita;Sabine Paternot;Françoise Rothé;Laure Twyffels;Sylvain Brohée;Ligia Craciun;Denis Larsimont;Véronique Kruys;Flavienne Sandras;Isabelle Salmon;Steven Van Laere;Martine Piccart;Michail Ignatiadis;Christos Sotiriou;Pierre P Roger
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第8期
- CDK4/6 inhibitors breast cancer cyclin‐dependent kinase 4 PD0332991 sensitivity biomarker;
40.CXCL12α/SDF‐1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals

机译：突触周围雪旺细胞的CXCL12α/ SDF-1促进受损运动轴突末端的再生
- 作者：Samuele Negro;Francesca Lessi;Elisa Duregotti;Paolo Aretini;Marco La Ferla;Sara Franceschi;Michele Menicagli;Elisanna Bergamin;Egle Radice;Marcus Thelen;Aram Megighian;Marco Pirazzini;Chiara M Mazzanti;Michela Rigoni;Cesare Montecucco
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第8期
- CXCL12 CXCR4 neuromuscular junction neuroregeneration perisynaptic Schwann cells;
41.Colorectal cancer‐initiating cells caught in the act

机译：大肠癌引发细胞参与其中
- 作者：Sebastian M Dieter;Hanno Glimm;Claudia R Ball
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第7期
42.SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia in homozygotes

机译：SPINK2缺乏症通过诱导纯合子的杂合子和无精子症的精子缺陷而导致不育
- 作者：Zine‐Eddine Kherraf;Marie Christou‐Kent;Thomas Karaouzene;Amir Amiri‐Yekta;Guillaume Martinez;Alexandra S Vargas;Emeline Lambert;Christelle Borel;Béatrice Dorphin;Isabelle Aknin‐Seifer;Michael J Mitchell;Catherine Metzler‐Guillemain;Jessica Escoffier;Serge Nef;Mariane Grepillat;Nicolas Thierry‐Mieg;Véronique Satre;Marc Bailly;Florence Boitrelle;Karin Pernet‐Gallay;Sylviane Hennebicq;Julien Fauré;Serge P Bottari;Charles Coutton;Pierre F Ray;Christophe Arnoult
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第8期
- azoospermia exome sequencing genetics infertility spermatogenesis;
43.MSTO1 is a cytoplasmic pro‐mitochondrial fusion protein whose mutation induces myopathy and ataxia in humans

机译：MSTO1是一种细胞质线粒体融合蛋白其突变可诱发人类肌病和共济失调
- 作者：Aniko Gal;Peter Balicza;David Weaver;Shamim Naghdi;Suresh K Joseph;Péter Várnai;Tibor Gyuris;Attila Horváth;Laszlo Nagy;Erin L Seifert;Maria Judit Molnar;György Hajnóczky
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第7期
- misato mitochondria mitochondrial disease mitochondrial fusion MSTO1;
44.A novel epigenetic AML1‐ETO/THAP10/miR‐383 mini‐circuitry contributes to t(8;21) leukaemogenesis

机译：新型表观遗传学AML1-ETO / THAP10 / miR-383微型电路有助于t（8; 21）白血病的发生
- 作者：Yonghui Li;Qiaoyang Ning;Jinlong Shi;Yang Chen;Mengmeng Jiang;Li Gao;Wenrong Huang;Yu Jing;Sai Huang;Anqi Liu;Zhirui Hu;Daihong Liu;Lili Wang;Clara Nervi;Yun Dai;Michael Q Zhang;Li Yu
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第7期
- AML1‐ETO epigenetics miR‐383 t(8;
- 21) AML THAP10;
45.γ‐Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct

机译：γ-分泌酶抑制剂在癌症临床试验中在药理学和功能上是不同的
- 作者：Yong Ran;Fokhrul Hossain;Antonio Pannuti;Christian B Lessard;Gabriela Z Ladd;Joo In Jung;Lisa M Minter;Barbara A Osborne;Lucio Miele;Todd E Golde
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第7期
- cancer therapy NOTCH γ‐secretase inhibitors;
46.Abnormal glycogen chain length pattern not hyperphosphorylation is critical in Lafora disease

机译：糖原链长度异常而不是磷酸化异常对拉福拉病至关重要
- 作者：Felix Nitschke;Mitchell A Sullivan;Peixiang Wang;Xiaochu Zhao;Erin E Chown;Ami M Perri;Lori Israelian;Lucia Juana‐López;Paola Bovolenta;Santiago Rodríguez de Córdoba;Martin Steup;Berge A Minassian
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第7期
- glycogen chain length glycogen phosphorylation Lafora disease laforin malin;
47.Specific biomarkers for C9orf72 FTD/ALS could expedite the journey towards effective therapies

机译：C9orf72的特定生物标记FTD / ALS可以加快实现有效疗法的过程
- 作者：Rubika Balendra;Thomas G Moens;Adrian M Isaacs
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第7期
48.Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases

机译：使用针对新血管眼疾病优化的双特异性CrossMAb靶向关键血管生成途径
- 作者：Jörg T Regula;Peter Lundh von Leithner;Richard Foxton;Veluchamy A Barathi;Chui Ming Gemmy Cheung;Sai Bo Bo Tun;Yeo Sia Wey;Daiju Iwata;Miroslav Dostalek;Jörg Moelleken;Kay G Stubenrauch;Everson Nogoceke;Gabriella Widmer;Pamela Strassburger;Michael J Koss;Christian Klein;David T Shima;Guido Hartmann
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第7期
49.Succession of transiently active tumor‐initiating cell clones in human pancreatic cancer xenografts

机译：人胰腺癌异种移植物中瞬时活性肿瘤起始细胞克隆的继承
- 作者：Claudia R Ball;Felix Oppel;Karl Roland Ehrenberg;Taronish D Dubash;Sebastian M Dieter;Christopher M Hoffmann;Ulrich Abel;Friederike Herbst;Moritz Koch;Jens Werner;Frank Bergmann;Naveed Ishaque;Manfred Schmidt;Christof von Kalle;Claudia Scholl;Stefan Fröhling;Benedikt Brors;Wilko Weichert;Jürgen Weitz;Hanno Glimm
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第7期
- clonal dynamics pancreatic cancer phenotypic plasticity tumor‐initiating cells;
50.Loss of Mpdz impairs ependymal cell integrity leading to perinatal‐onset hydrocephalus in mice

机译：Mpdz的丧失会损害小鼠的室管膜细胞完整性导致围产期发作性脑积水
- 作者：Anja Feldner;M Gordian Adam;Fabian Tetzlaff;Iris Moll;Dorde Komljenovic;Felix Sahm;Tobias Bäuerle;Hiroshi Ishikawa;Horst Schroten;Thomas Korff;Ilse Hofmann;Hartwig Wolburg;Andreas von Deimling;Andreas Fischer
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第7期
- aqueductal stenosis cerebrospinal fluid ependymal cells hydrocephalus tight junction;
51.DOK7 gene therapy enhances motor activity and life span in ALS model mice

机译：DOK7基因疗法可增强ALS模型小鼠的运动活动和寿命
- 作者：Sadanori Miyoshi;Tohru Tezuka;Sumimasa Arimura;Taro Tomono;Takashi Okada;Yuji Yamanashi
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第7期
- amyotrophic lateral sclerosis DOK7 gene therapy neuromuscular junction;
52.A genome editing approach to study cancer stem cells in human tumors

机译：研究人类肿瘤中癌症干细胞的基因组编辑方法
- 作者：Carme Cortina;Gemma Turon;Diana Stork;Xavier Hernando‐Momblona;Marta Sevillano;Mònica Aguilera;Sébastien Tosi;Anna Merlos‐Suárez;Camille Stephan‐Otto Attolini;Elena Sancho;Eduard Batlle
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第7期
- cancer stem cells colorectal cancer CRISPR/Cas9 LGR5;
53.Transient transcription factor (OSKM) expression is key towards clinical translation of in vivo cell reprogramming

机译：瞬时转录因子（OSKM）表达是体内细胞重编程临床翻译的关键
- 作者：Irene de Lázaro;Giulio Cossu;Kostas Kostarelos
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第6期
54.Administration of RANKL boosts thymic regeneration upon bone marrow transplantation

机译：RANKL的给药可促进骨髓移植后的胸腺再生
- 作者：Noella Lopes;Hortense Vachon;Julien Marie;Magali Irla
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第6期
- bone marrow transplantation lymphotoxin α receptor activator of nuclear factor kappa B ligand T‐cell reconstitution thymic regeneration;
55.VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis

机译：VEGFR2而不是VEGFR3控制正常状态和甲状腺肿形成过程中甲状腺血管滤泡单位的完整性和重塑
- 作者：Jeon Yeob Jang;Sung Yong Choi;Intae Park;Do Young Park;Kibaek Choe;Pilhan Kim;Young Keum Kim;Byung‐Joo Lee;Masanori Hirashima;Yoshiaki Kubota;Jeong‐Won Park;Sheue‐Yann Cheng;Andras Nagy;Young Joo Park;Kari Alitalo;Minho Shong;Gou Young Koh
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第6期
- thyroid angiofollicular unit thyroid goitrogenesis vascular remodeling VEGFR2;
56.Poly‐GP in cerebrospinal fluid links C9orf72‐associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD

机译：脑脊液中的Poly-GP将C9orf72相关的二肽重复表达与ALS / FTD的无症状期联系起来
- 作者：Carina Lehmer;Patrick Oeckl;Jochen H Weishaupt;Alexander E Volk;Janine Diehl‐Schmid;Matthias L Schroeter;Martin Lauer;Johannes Kornhuber;Johannes Levin;Klaus Fassbender;Bernhard Landwehrmeyer;Martin H Schludi;Thomas Arzberger;Elisabeth Kremmer;Andrew Flatley;Regina Feederle;Petra Steinacker;Patrick Weydt;Albert C Ludolph;Dieter Edbauer;Markus Otto;Adrian Danek;Emily Feneberg;Sarah Anderl‐Straub;Christine von Arnim;Holger Jahn;Anja Schneider;Manuel Maler;Maryna Polyakova;Lina Riedl;Jens Wiltfang;Georg Ziegler
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第7期
- amyotrophic lateral sclerosis biomarker C9orf72 cerebrospinal fluid frontotemporal dementia;
57.Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice

机译：抑制PIKfyve通过激活肥胖小鼠中的SIRT3来预防心肌细胞凋亡和肥大
- 作者：Helene Tronchere;Mathieu Cinato;Andrei Timotin;Laurie Guitou;Camille Villedieu;Helene Thibault;Delphine Baetz;Bernard Payrastre;Philippe Valet;Angelo Parini;Oksana Kunduzova;Frederic Boal
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第6期
- apoptosis cardiac hypertrophy mitochondria PIKfyve SIRT3;
58.Gene therapy for ADA‐SCID the first marketing approval of an ex vivo gene therapy in Europe: paving the road for the next generation of advanced therapy medicinal products

机译：ADA‐SCID的基因疗法是欧洲前体外基因疗法的首个市场批准：为下一代高级疗法药物产品铺平道路
- 作者：Alessandro Aiuti;Maria Grazia Roncarolo;Luigi Naldini
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第6期
59.A clinical and mechanistic study of topical borneol‐induced analgesia

机译：冰片局部镇痛的临床和机制研究
- 作者：Shu Wang;Dan Zhang;Jinsheng Hu;Qi Jia;Wei Xu;Deyuan Su;Hualing Song;Zhichun Xu;Jianmin Cui;Ming Zhou;Jian Yang;Jianru Xiao
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第6期
- borneol pain topical analgesic traditional Chinese medicine TRPM8;
60.Ferrochelatase is a therapeutic target for ocular neovascularization

机译：铁螯合酶是眼新血管形成的治疗靶标
- 作者：Halesha D Basavarajappa;Rania S Sulaiman;Xiaoping Qi;Trupti Shetty;Sardar Sheik Pran Babu;Kamakshi L Sishtla;Bit Lee;Judith Quigley;Sameerah Alkhairy;Christian M Briggs;Kamna Gupta;Buyun Tang;Mehdi Shadmand;Maria B Grant;Michael E Boulton;Seung‐Yong Seo;Timothy W Corson
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第6期
- age‐related macular degeneration angiogenesis ferrochelatase griseofulvin heme synthesis;
61.RIG‐I antiviral signaling drives interleukin‐23 production and psoriasis‐like skin disease

机译：RIG-I抗病毒信号驱动白介素23产生和牛皮癣样皮肤病
- 作者：Huiyuan Zhu;Fangzhou Lou;Qianqian Yin;Yuanyuan Gao;Yang Sun;Jing Bai;Zhenyao Xu;Zhaoyuan Liu;Wei Cai;Fang Ke;Lingyun Zhang;Hong Zhou;Hong Wang;Gang Wang;Xiang Chen;Hongxin Zhang;Zhugang Wang;Florent Ginhoux;Chuanjian Lu;Bing Su;Honglin Wang
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第5期
- DCs interleukin‐23 NF‐κB psoriasis RIG‐I;
62.Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin

机译：肝星状细胞通过孤儿受体内皮唾液酸蛋白限制肝癌的进展
- 作者：Carolin Mogler;Courtney König;Matthias Wieland;Anja Runge;Eva Besemfelder;Dorde Komljenovic;Thomas Longerich;Peter Schirmacher;Hellmut G Augustin
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第6期
- cancer HCC stromal cross talk tumor stroma vascular biology;
63.Transcriptional response to hepatitis C virus infection and interferon‐alpha treatment in the human liver

机译：对丙型肝炎病毒感染和人类肝脏干扰素治疗的转录反应
- 作者：Tujana Boldanova;Aleksei Suslov;Markus H Heim;Anamaria Necsulea
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第6期
- HCV hepatitis C interferon miRNAs transcriptome;
64.An intranasally delivered peptide drug ameliorates cognitive decline in Alzheimer transgenic mice

机译：鼻内给药的肽药物可改善阿尔茨海默病转基因小鼠的认知能力下降
- 作者：Yu‐Sung Cheng;Zih‐ten Chen;Tai‐Yan Liao;Chen Lin;Howard C‐H Shen;Ya‐Han Wang;Chi‐Wei Chang;Ren‐Shyan Liu;Rita P‐Y Chen;Pang‐hsien Tu
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第5期
- Aβ Alzheimer disease peptide therapy polyarginine polyethylenimine;
65.Antibodies inhibit transmission and aggregation of C9orf72 poly‐GA dipeptide repeat proteins

机译：抗体抑制C9orf72 poly-GA二肽重复蛋白的传播和聚集
- 作者：Qihui Zhou;Carina Lehmer;Meike Michaelsen;Kohji Mori;Dominik Alterauge;Dirk Baumjohann;Martin H Schludi;Johanna Greiling;Daniel Farny;Andrew Flatley;Regina Feederle;Stephanie May;Franziska Schreiber;Thomas Arzberger;Christoph Kuhm;Thomas Klopstock;Andreas Hermann;Christian Haass;Dieter Edbauer
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第5期
- amyotrophic lateral sclerosis C9orf72 immunotherapy RAN translation seeding;
66.Seeding and transgenic overexpression of alpha‐synuclein triggers dendritic spine pathology in the neocortex

机译：α-突触核蛋白的播种和转基因过表达触发了新皮层的树突棘病理
- 作者：Sonja Blumenstock;Eva F Rodrigues;Finn Peters;Lidia Blazquez‐Llorca;Felix Schmidt;Armin Giese;Jochen Herms
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第5期
- alpha‐synuclein dendritic spines in vivo imaging seeding synucleinopathies;
67.Niacin ameliorates ulcerative colitis via prostaglandin D2‐mediated D prostanoid receptor 1 activation

机译：烟酸通过前列腺素D2介导的D前列腺素受体1激活改善溃疡性结肠炎
- 作者：Juanjuan Li;Deping Kong;Qi Wang;Wei Wu;Yanping Tang;Tingting Bai;Liang Guo;Lumin Wei;Qianqian Zhang;Yu Yu;Yuting Qian;Shengkai Zuo;Guizhu Liu;Qian Liu;Sheng Wu;Yi Zang;Qian Zhu;Daile Jia;Yuanyang Wang;Weiyan Yao;Yong Ji;Huiyong Yin;Masataka Nakamura;Michael Lazarus;Richard M Breyer;Lifu Wang;Ying Yu
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第5期
- DP1 receptor niacin prostaglandin retention enema ulcerative colitis;
68.Moving molecular medicine

机译：移动分子医学
- 作者：Philippe J Sansonetti
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第4期
69.Pre‐clinical validation of a selective anti‐cancer stem cell therapy for Numb‐deficient human breast cancers

机译：麻木缺乏人乳腺癌的选择性抗癌干细胞疗法的临床前验证
- 作者：Daniela Tosoni;Sarah Pambianco;Blanche Ekalle Soppo;Silvia Zecchini;Giovanni Bertalot;Giancarlo Pruneri;Giuseppe Viale;Pier Paolo Di Fiore;Salvatore Pece
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第5期
- breast cancer cancer stem cells Numb p53 primary‐derived xenografts;
70.Delivery is key: lessons learnt from developing splice‐switching antisense therapies

机译：交付是关键：从开发剪接切换反义疗法中学到的经验教训
- 作者：Caroline Godfrey;Lourdes R Desviat;Bård Smedsrød;France Piétri‐Rouxel;Michela A Denti;Petra Disterer;Stéphanie Lorain;Gisela Nogales‐Gadea;Valentina Sardone;Rayan Anwar;Samir EL Andaloussi;Taavi Lehto;Bernard Khoo;Camilla Brolin;Willeke MC van Roon‐Mom;Aurélie Goyenvalle;Annemieke Aartsma‐Rus;Virginia Arechavala‐Gomeza
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第5期
- antisense oligonucleotides delivery pre‐clinical models RNA therapy toxicity;
71.Deletion of F4L (ribonucleotide reductase) in vaccinia virus produces a selective oncolytic virus and promotes anti‐tumor immunity with superior safety in bladder cancer models

机译：牛痘病毒中F4L（核糖核苷酸还原酶）的缺失产生选择性溶瘤病毒并在膀胱癌模型中以更高的安全性促进抗肿瘤免疫
- 作者：Kyle G Potts;Chad R Irwin;Nicole A Favis;Desmond B Pink;Krista M Vincent;John D Lewis;Ronald B Moore;Mary M Hitt;David H Evans
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第5期
- bladder cancer immunotherapy oncolytic virus ribonucleotide reductase vaccinia virus;
72.Culturing human intestinal stem cells for regenerative applications in the treatment of inflammatory bowel disease

机译：培养人肠道干细胞以再生应用治疗炎性肠病
- 作者：Fredrik EO Holmberg;Jakob B Seidelin;Xiaolei Yin;Benjamin E Mead;Zhixiang Tong;Yuan Li;Jeffrey M Karp;Ole H Nielsen
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第5期
- inflammatory bowel disease intestinal stem cells organoids regenerative medicine support matrix;
73.TFE3 regulates whole‐body energy metabolism in cooperation with TFEB

机译：TFE3与TFEB协同调节全身能量代谢
- 作者：Nunzia Pastore;Anna Vainshtein;Tiemo J Klisch;Andrea Armani;Tuong Huynh;Niculin J Herz;Elena V Polishchuk;Marco Sandri;Andrea Ballabio
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第5期
- lipid metabolism mitochondrial dynamics physical exercise TFE3 TFEB;
74.Ethics of stem cell‐derived gametes made in a dish: fertility for everyone?

机译：在一碟中制成的干细胞配子的伦理学：每个人的生育力？
- 作者：Annelien L Bredenoord;Insoo Hyun
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第4期
75.PPARG is central to the initiation and propagation of human angiomyolipoma suggesting its potential as a therapeutic target

机译：PPARG对人类血管平滑肌脂肪瘤的起始和传播至关重要表明其作为治疗靶标的潜力
- 作者：Oren Pleniceanu;Racheli Shukrun;Dorit Omer;Einav Vax;Itamar Kanter;Klaudyna Dziedzic;Naomi Pode‐Shakked;Michal Mark‐Daniei;Sara Pri‐Chen;Yehudit Gnatek;Hadas Alfandary;Nira Varda‐Bloom;Dekel D Bar‐Lev;Naomi Bollag;Rachel Shtainfeld;Leah Armon;Achia Urbach;Tomer Kalisky;Arnon Nagler;Orit Harari‐Steinberg;Jack L Arbiser;Benjamin Dekel
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第4期
- angiomyolipoma cancer stem cells mesenchymal stem cells PPARG tuberous sclerosis complex;
76.Gene expression profiling of patient‐derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts

机译：患者源性胰腺癌异种移植物的基因表达谱预测对BET溴结构域抑制剂JQ1的敏感性：对个体化药物研究的意义
- 作者：Benjamin Bian;Martin Bigonnet;Odile Gayet;Celine Loncle;Aurélie Maignan;Marine Gilabert;Vincent Moutardier;Stephane Garcia;Olivier Turrini;Jean‐Robert Delpero;Marc Giovannini;Philippe Grandval;Mohamed Gasmi;Mehdi Ouaissi;Veronique Secq;Flora Poizat;Rémy Nicolle;Yuna Blum;Laetitia Marisa;Marion Rubis;Jean‐Luc Raoul;James E Bradner;Jun Qi;Gwen Lomberk;Raul Urrutia;Andres Saul;Nelson Dusetti;Juan Iovanna
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第4期
- bromodomains c‐MYC JQ1 pancreatic adenocarcinoma transcriptomic signature;
77.Supraphysiological levels of GDF11 induce striated muscle atrophy

机译：超生理水平的GDF11诱发横纹肌萎缩
- 作者：David W Hammers;Melissa Merscham‐Banda;Jennifer Ying Hsiao;Stefan Engst;James J Hartman;H Lee Sweeney
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第4期
- activin receptor cachexia cardiac atrophy muscle mass myostatin;
78.STAT3 promotes IFNγ/TNFα‐induced muscle wasting in an NF‐κB‐dependent and IL‐6‐independent manner

机译：STAT3以NF-κB依赖性和IL-6依赖性的方式促进IFNγ/TNFα诱导的肌肉消瘦
- 作者：Jennifer F Ma;Brenda J Sanchez;Derek T Hall;Anne‐Marie K Tremblay;Sergio Di Marco;Imed‐Eddine Gallouzi
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第5期
- inflammation iNOS muscle wasting NF‐κB STAT3;
79.Deletion of ribosomal protein genes is a common vulnerability in human cancer especially in concert with TP53 mutations

机译：核糖体蛋白基因的缺失是人类癌症的普遍脆弱性尤其是与TP53突变协同作用时
- 作者：Ram Ajore;David Raiser;Marie McConkey;Magnus Jöud;Bernd Boidol;Brenton Mar;Gordon Saksena;David M Weinstock;Scott Armstrong;Steven R Ellis;Benjamin L Ebert;Björn Nilsson
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第4期
- cancer ribosomal gene haploinsufficiency ribosome function;
80.Sodium leak through K2P potassium channels and cardiac arrhythmia an emerging theme

机译：通过K2P钾通道和心脏心律不齐引起的钠泄漏这是一个新兴主题
- 作者：Steve AN Goldstein
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第4期
81.Gene signature driving invasive mucinous adenocarcinoma of the lung

机译：基因签名驱动肺部浸润性黏液腺癌
- 作者：Minzhe Guo;Koichi Tomoshige;Michael Meister;Thomas Muley;Takuya Fukazawa;Tomoshi Tsuchiya;Rebekah Karns;Arne Warth;Iris M Fink‐Baldauf;Takeshi Nagayasu;Yoshio Naomoto;Yan Xu;Marcus A Mall;Yutaka Maeda
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第4期
- FOXA3 IMA MUC5AC/5B SPDEF VTCN1;
82.Sodium permeable and hypersensitive TREK‐1 channels cause ventricular tachycardia

机译：钠渗透性和超敏性 TREK-1通道引起室性心动过速
- 作者：Niels Decher;Beatriz Ortiz‐Bonnin;Corinna Friedrich;Marcus Schewe;Aytug K Kiper;Susanne Rinné;Gunnar Seemann;Rémi Peyronnet;Sven Zumhagen;Daniel Bustos;Jens Kockskämper;Peter Kohl;Steffen Just;Wendy González;Thomas Baukrowitz;Birgit Stallmeyer;Eric Schulze‐Bahr
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第4期
- arrhythmia K2P RVOT TREK‐1 two‐pore domain Ksup+/sup channel;
83.Faecal microbiota transplantation protects against radiation‐induced toxicity

机译：粪便菌群移植可防止辐射诱发的毒性
- 作者：Ming Cui;Huiwen Xiao;Yuan Li;Lixin Zhou;Shuyi Zhao;Dan Luo;Qisheng Zheng;Jiali Dong;Yu Zhao;Xin Zhang;Junling Zhang;Lu Lu;Haichao Wang;Saijun Fan
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第4期
- faecal microbiota transplantation gastrointestinal toxicity gut microbiota radiation syndrome radiotherapy;
84.SK4 K+ channels are therapeutic targets for the treatment of cardiac arrhythmias

机译：SK4 K +通道是治疗心律不齐的治疗靶标
- 作者：Shiraz Haron‐Khun;David Weisbrod;Hanna Bueno;Dor Yadin;Joachim Behar;Asher Peretz;Ofer Binah;Edith Hochhauser;Michael Eldar;Yael Yaniv;Michael Arad;Bernard Attali
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第4期
- cardiac arrhythmia catecholaminergic polymorphic ventricular tachycardia pacemaker potassium channel SK4;
85.A Klebsiella pneumoniae antibiotic resistance mechanism that subdues host defences and promotes virulence

机译：克制肺炎克雷伯菌的抗生素抗性机制可减轻宿主防御能力并提高毒力
- 作者：Timothy J Kidd;Grant Mills;Joana Sá‐Pessoa;Amy Dumigan;Christian G Frank;José L Insua;Rebecca Ingram;Laura Hobley;José A Bengoechea
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第4期
- antimicrobial peptides Klebsiella pneumoniae mgrB polymyxins virulence;
86.VEGFA activates an epigenetic pathway upregulating ovarian cancer‐initiating cells

机译：VEGFA激活上调卵巢癌起始细胞的表观遗传途径
- 作者：Kibeom Jang;Minsoon Kim;Candace A Gilbert;Fiona Simpkins;Tan A Ince;Joyce M Slingerland
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第3期
- Bmi1 cancer stem‐like cell epigenetic miR‐128 VEGFA;
87.Y RNA fragment in extracellular vesicles confers cardioprotection via modulation of IL‐10 expression and secretion

机译：细胞外小泡中的Y RNA片段通过调节IL-10表达和分泌赋予心脏保护作用
- 作者：Linda Cambier;Geoffrey de Couto;Ahmed Ibrahim;Antonio K Echavez;Jackelyn Valle;Weixin Liu;Michelle Kreke;Rachel R Smith;Linda Marbán;Eduardo Marbán
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第3期
- extracellular vesicle macrophage RNA stem cells;
88.PERK activation mitigates tau pathology in vitro and in vivo

机译：PERK激活可减轻体外和体内tau病理
- 作者：Julius Bruch;Hong Xu;Thomas W Rösler;Anderson De Andrade;Peer‐Hendrik Kuhn;Stefan F Lichtenthaler;Thomas Arzberger;Konstanze F Winklhofer;Ulrich Müller;Günter U Höglinger
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第3期
- EIF2A NRF2 PERK progressive supranuclear palsy tauopathy;
89.Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis

机译：靶向弓形虫CPSF3作为控制弓形虫病的新方法
- 作者：Andrés Palencia;Alexandre Bougdour;Marie‐Pierre Brenier‐Pinchart;Bastien Touquet;Rose‐Laurence Bertini;Cristina Sensi;Gabrielle Gay;Julien Vollaire;Véronique Josserand;Eric Easom;Yvonne R Freund;Hervé Pelloux;Philip J Rosenthal;Stephen Cusack;Mohamed‐Ali Hakimi
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第3期
- benzoxaborole CPSF3 drug discovery mRNA processing Toxoplasma gondii toxoplasmosis;
90.Patient‐driven search for rare disease therapies: the Fondazione Telethon success story and the strategy leading to Strimvelis

机译：以患者为导向的稀有疾病疗法搜索：Fondazione Telethon成功案例和导致Strimvelis的策略
- 作者：Lucia Monaco;Lucia Faccio
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第3期
91.Modulation of mTOR signaling as a strategy for the treatment of Pompe disease

机译：调节mTOR信号作为庞贝病的治疗策略
- 作者：Jeong‐A Lim;Lishu Li;Orian S Shirihai;Kyle M Trudeau;Rosa Puertollano;Nina Raben
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第3期
- autophagy lysosomal storage disorders mTOR myopathy Pompe disease;
92.Organization and function of neuronal circuits controlling movement

机译：控制运动的神经回路的组织和功能
- 作者：Silvia Arber;*
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第3期
93.Sensing infection and tissue damage

机译：感知感染和组织损伤
- 作者：Caetano Reis e Sousa;*
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第3期
94.Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions

机译：AXIN1的缺失驱动携带RSPO3融合蛋白的结直肠癌细胞对WNT途径阻滞的获得性耐药
- 作者：Gabriele Picco;Consalvo Petti;Alessia Centonze;Erica Torchiaro;Giovanni Crisafulli;Luca Novara;Andrea Acquaviva;Alberto Bardelli;Enzo Medico
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第3期
- colorectal cancer gene fusion R‐spondin targeted therapy WNT pathway;
95.Sequence variation in PPP1R13L results in a novel form of cardio‐cutaneous syndrome

机译：PPP1R13L中的序列变异导致一种新型的心皮综合症
- 作者：Tzipora C Falik‐Zaccai;Yiftah Barsheshet;Hanna Mandel;Meital Segev;Avraham Lorber;Shachaf Gelberg;Limor Kalfon;Shani Ben Haroush;Adel Shalata;Liat Gelernter‐Yaniv;Sarah Chaim;Dorith Raviv Shay;Morad Khayat;Michal Werbner;Inbar Levi;Yishay Shoval;Galit Tal;Stavit Shalev;Eli Reuveni;Emily Avitan‐Hersh;Eugene Vlodavsky;Liat Appl‐Sarid;Dorit Goldsher;Reuven Bergman;Zvi Segal;Ora Bitterman‐Deutsch;Orly Avni
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第3期
- dilated cardiomyopathy genetics inflammation myocarditis PPP1R13L;
96.The transcription factor GATA4 promotes myocardial regeneration in neonatal mice

机译：转录因子GATA4促进新生小鼠的心肌再生
- 作者：Mona Malek Mohammadi;Badder Kattih;Andrea Grund;Natali Froese;Mortimer Korf‐Klingebiel;Anna Gigina;Ulrike Schrameck;Carsten Rudat;Qiangrong Liang;Andreas Kispert;Kai C Wollert;Johann Bauersachs;Joerg Heineke
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第2期
- cardiac regeneration cardiomyocyte proliferation GATA4 IL‐13 neonatal cryoinfarction;
97.ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth

机译：ROCK信号促进胶原蛋白重塑促进侵袭性胰腺导管腺癌肿瘤细胞生长
- 作者：Nicola Rath;Jennifer P Morton;Linda Julian;Lena Helbig;Shereen Kadir;Ewan J McGhee;Kurt I Anderson;Gabriela Kalna;Margaret Mullin;Andreia V Pinho;Ilse Rooman;Michael S Samuel;Michael F Olson
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第2期
- collagen remodeling extracellular matrix pancreatic cancer ROCK kinases tumor cell invasion;
98.How to tackle antimalarial resistance?

机译：如何应对抗疟疾？
- 作者：Didier Leroy
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第2期
99.Genetically engineered mouse models in oncology research and cancer medicine

机译：肿瘤研究和癌症医学中的基因工程小鼠模型
- 作者：Kelly Kersten;Karin E de Visser;Martine H van Miltenburg;Jos Jonkers
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第2期
- cancer genetically engineered mouse models metastasis therapy tumor microenvironment;
100.Reprogramming‐derived gene cocktail increases cardiomyocyte proliferation for heart regeneration

机译：重编程来源的基因混合物可增加心肌细胞的增殖促进心脏再生
- 作者：Yuan‐Yuan Cheng;Yu‐Ting Yan;David J Lundy;Annie HA Lo;Yu‐Ping Wang;Shu‐Chian Ruan;Po‐Ju Lin;Patrick CH Hsieh
- 期刊名称：《EMBO Molecular Medicine》 | 2017年第2期
- cardiomyocyte proliferation gene therapy heart regeneration myocardial infarction reprogramming;