A thienopyridine CB-20 exerts diuretic activity by inhibiting urea transporters

摘要

Activity of CB-20 against mouse, rat, and human UT-B. a Chemical structure of CB-20. b Dose-dependent inhibitory activity of CB-20, as determined by an osmotic lysis assay in erythrocytes of UT-B−/− mice and wild-type mice, rats, and humans. c IC50 value of CB-20 on UT-B-facilitated urea transport