Chermebilaenes A and B New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates of Penicillium bilaiae MA-267 and Penicillium chermesinum EN-480

摘要

The co-cultivation of two or more different microbial strains in one culture vessel was supposed to be a viable experimental approach for enhancing the diversity of the compounds produced. Two new meroterpenoid derivatives, chermebilaenes A ( ) and B ( ), together with three known sesquiterpenoids, sesquicaranoic acid B ( ), cyclonerodiol ( ) and bisabol-l-on-13-säuremethylester ( ), were characterized from a co-culture of the marine-derived fungal isolates of MA-267 and EN-480. Neither fungus produced these compounds when cultured alone under the same conditions. Compound represents an unprecedented acorane-type sesquiterpene hybridized with an octadecadienoic acid skeleton. The structures were elucidated on the basis of spectroscopic analysis, and the absolute configurations were assumed on the basis of acidic hydrolysis combined with modified Mosher’s method and electronic circular dichroism (ECD) calculations. Compound showed potent inhibitory activities against and .