Fasting induces remodeling of the orexigenic projections from the arcuate nucleus to the hypothalamic paraventricular nucleus in a growth hormone secretagogue receptor–dependent manner

摘要

Arcuate nucleus (ARC) neurons producing Agouti-related peptide (AgRP) and neuropeptide Y (NPY; ARC neurons) are activated under energy-deficit states. ARC neurons innervate the hypothalamic paraventricular nucleus (PVH), and ARC→PVH projections are recognized as key regulators of food intake. Plasma ghrelin levels increase under energy-deficit states and activate ARC neurons by acting on the growth hormone secretagogue receptor (GHSR). Here, we hypothesized that activation of ARC neurons in fasted mice would promote morphological remodeling of the ARC →PVH projections in a GHSR-dependent manner.