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Molecular Metabolism

中文名称：分子代谢

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1.Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism

机译：非规范性NRF2活化促进肝葡萄糖代谢中的促糖尿病率
- 作者：Pengfei Liu;Matthew Dodson;Hui Li;Cody J. Schmidlin;Aryatara Shakya;Yongyi Wei;Joe G.N. Garcia;Eli Chapman;Pawel R. Kiela;Qing-Yu Zhang;Eileen White;Xinxin Ding;Aikseng Ooi;Donna D. Zhang
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- DiabetesPolyol pathwayLiver carbohydrate metabolismNRF2;
2.White adipose remodeling during browning in mice involves YBX1 to drive thermogenic commitment

机译：在老鼠中褐变期间的白色脂肪改造涉及YBX1以推动热原承诺
- 作者：Atefeh Rabiee;Kaja Plucińska;Marie Sophie Isidor;Erin Louise Brown;Marco Tozzi;Simone Sidoli;Patricia Stephanie S. Petersen;Marina Agueda-Oyarzabal;Silje B?en Torsetnes;Galal Nazih Chehabi;Morten Lundh;Ali Alt?nta?;Romain Barrès;Ole N?rregaard Jensen;Zachary Gerhart-Hines;Brice Emanuelli
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Brite/beige adipose tissueAdipocyteBrowningTemporal proteomicYBX1Transcriptional regulation;
3.Metabolic-associated fatty liver disease and lipoprotein metabolism

机译：代谢相关的脂肪肝疾病和脂蛋白代谢
- 作者：Joerg Heeren;Ludger Scheja
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- LipoproteinNAFLDAdipose tissueTriglyceridesDe novo lipogenesisLiver;
4.Metabolic drivers of non-alcoholic fatty liver disease

机译：非酒精脂肪肝病的代谢驱动因素
- 作者：Kendra K. Bence;Morris J. Birnbaum
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- NAFLDNASHObesityAdipose tissueLipotoxicityFructose;
5.The effects of housing density on mouse thermal physiology depend on sex and ambient temperature

机译：壳体密度对小鼠热生理学的影响取决于性和环境温度
- 作者：Vojtěch ?kop;Cuiying Xiao;Naili Liu;Oksana Gavrilova;Marc L. Reitman
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Body temperatureEnergy expenditureHousing densitySex differencesBombesin receptor subtype-3 (BRS3BB3)Ambient temperatureBRS3 bombesin receptor subtype-3RER respiratory exchange ratioTa ambient temperature(s)Tb core body temperatureTEE total energy expenditureTNP D dark phase thermoneutral pointTNP L light phase thermoneutral point;
6.Exploring the therapeutic potential of mitochondrial uncouplers in cancer

机译：探索癌症线粒体脱孔器的治疗潜力
- 作者：Riya Shrestha;Edward Johnson;Frances L. Byrne
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Mitochondrial uncouplersCancer therapyCytotoxicityMouse models of cancer;
7.Direct small molecule ADaM-site AMPK activators reveal an AMPKγ3-independent mechanism for blood glucose lowering

机译：直接小分子ADAM-PABY AMPK激活剂揭示了AMPKγ3的血糖血糖降低机制
- 作者：Nicolas O. J?rgensen;Rasmus Kj?bsted;Magnus R. Larsen;Jesper B. Birk;Nicoline R. Andersen;Bina Albuquerque;Peter Schjerling;Russell Miller;David Carling;Christian K. Pehm?ller;J?rgen F.P. Wojtaszewski
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- AMP-activated protein kinaseSkeletal muscleGlucose uptakeMetabolismMetabolic disease;
8.The gut–brain axis: Identifying new therapeutic approaches for type 2 diabetes, obesity, and related disorders

机译：肠脑轴：鉴定2型糖尿病，肥胖症和相关疾病的新治疗方法
- 作者：Paul Richards;Nancy A. Thornberry;Shirly Pinto
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Gut-brain axisDiabetesObesityGut peptidesVagus;
9.Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes

机译：多巴胺D2受体激动剂，溴隐亭，重新涂抹脂肪组织多巴胺能信号传导和上调分解代谢途径，改善2型糖尿病中的代谢型材
- 作者：G. Tavares;D. Marques;C. Barra;D. Rosendo-Silva;A. Costa;T. Rodrigues;P. Gasparini;B.F. Melo;J.F. Sacramento;R. Sei?a;S.V. Conde;P. Matafome
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Type 2 diabetesObesityDopamineBromocriptineD2 dopamine receptorAdipose tissueLiver;
10.A pyrexic effect of FGF21 independent of energy expenditure and UCP1

机译：FGF21独立于能源支出和UCP1的嗜好效果
- 作者：Petr Zouhar;Petra Janovska;Sara Stanic;Kristina Bardova;Jiri Funda;Blanka Haberlova;Birgitte Andersen;Martin Rossmeisl;Barbara Cannon;Jan Kopecky;Jan Nedergaard
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- UCP1ThermoneutralityBeiging/browningObesityBody temperature control;
11.Fate of adipocyte progenitors during adipogenesis in mice fed a high-fat diet

机译：在喂养高脂饮食的小鼠脂肪发生过程中脂肪细胞祖细胞的命运
- 作者：Muhammad Bilal;Allah Nawaz;Tomonobu Kado;Muhammad Rahil Aslam;Yoshiko Igarashi;Ayumi Nishimura;Yoshiyuki Watanabe;Takahide Kuwano;Jianhui Liu;Hiroyuki Miwa;Takumi Era;Koichi Ikuta;Johji Imura;Kunimasa Yagi;Takashi Nakagawa;Shiho Fujisaka;Kazuyuki Tobe
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Adipocyte hyperplasiaObesityAdipogenesisAdipocyte progenitors;
12.Distinct roles of UVRAG and EGFR signaling in skeletal muscle homeostasis

机译：UVRAG和EGFR信号在骨骼肌稳态中的不同作用
- 作者：Min Jeong Kim;Daniella Febbraro;Sofia Farkona;Taylor Gillmore;Joe Eun Son;Romario Regeenes;Huntley H. Chang;Evan Pollock-Tahiri;Jiaqi Yang;Yoo Jin Park;Tharini Sivasubramaniyam;Soo Jung Oh;Punit Saraon;Igor Stagljar;Jonathan V. Rocheleau;Chi-Chung Hui;Isabella Caniggia;Zhenyu Hao;Tak W. Mak;Ana Konvalinka
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- UVRAGSkeletal muscleFgf21Mitochondrial dynamicsEGFR;
13.Centrally circulating α-klotho inversely correlates with human obesity and modulates arcuate cell populations in mice

机译：集中循环α-Klotho与人类肥胖相反，并调节小鼠的弧形细胞群
- 作者：Taylor Landry;Peixin Li;Daniel Shookster;Zhiying Jiang;Hongli Li;Brenton Thomas Laing;Wyatt Bunner;Theodore Langton;Qingchun Tong;Hu Huang
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- α-KlothoMetabolismObesityPOMC neuronFibroblast growth factorPI3kinase;
14.Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice

机译：表达葡萄糖酮酶的昏昏度影响能量平衡并增加小鼠的肥胖
- 作者：Antoine Rohrbach;Emilie Caron;Rafik Dali;Maxime Brunner;Roxane Pasquettaz;Irina Kolotuev;Federico Santoni;Bernard Thorens;Fanny Langlet
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- GlucokinaseTanycytesEnergy balanceGlucose homeostasisApoptosisHypothalamus2-DG 2-deoxyglucoseAgRP agouti-related peptideARH arcuate nucleusCART cocaineand amphetamine-related transcriptDIO2 deiodinase 2DMH dorsomedial nucleusGCK glucokinaseME median eminenceNPY neuropeptide YPOMC proopiomelanocortinvmARH ventromedial arcuate nucleusVMH ventromedial nucleus;
15.Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction

机译：酮酮的药理学抑制阻止果糖诱导的代谢功能障碍
- 作者：Jemy A. Gutierrez;Wei Liu;Sylvie Perez;Gang Xing;Gabriele Sonnenberg;Kou Kou;Matt Blatnik;Richard Allen;Yan Weng;Nicholas B. Vera;Kristin Chidsey;Arthur Bergman;Veena Somayaji;Collin Crowley;Michelle F. Clasquin;Anu Nigam;Melissa A. Fulham;Derek M. Erion;Trenton T. Ross;William P. Esler
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- FructoseKHKInsulin resistanceNAFLDMetabolic disease;
16.Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application

机译：应对肥胖治疗的挑战能源支出的挑战：从临床前模型到临床应用
- 作者：Mona C. L?ffler;Matthias J. Betz;Denis P. Blondin;Robert Augustin;Anand K. Sharma;Yu-Hua Tseng;Camilla Scheele;Heike Zimdahl;Michael Mark;Anita M. Hennige;Christian Wolfrum;Wolfgang Langhans;Bradford S. Hamilton;Heike Neubauer
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- ObesityEnergy homeostasisEnergy expenditureMethodologyClinical translatability;
17.Hemostatic alterations linked to body fat distribution, fatty liver, and insulin resistance

机译：与体脂分布，脂肪肝和胰岛素抵抗有关的止血改变
- 作者：Sebastian H?rber;Rainer Lehmann;Norbert Stefan;Jürgen Machann;Andreas L. Birkenfeld;Robert Wagner;Martin Heni;Hans-Ulrich H?ring;Andreas Fritsche;Andreas Peter
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Body fat distributionAbdominal obesityLiver fatPrediabetesCoagulation;
18.CRISPR knockdown of Kcnq3 attenuates the M-current and increases excitability of NPY/AgRP neurons to alter energy balance

机译：KCNQ3的CRISPR敲低衰减了M-Current并提高了NPY / AGRP神经元的兴奋性以改变能量平衡
- 作者：Todd L. Stincic;Martha A. Bosch;Avery C. Hunker;Barbara Juarez;Ashley M. Connors;Larry S. Zweifel;Oline K. R?nnekleiv;Martin J. Kelly
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Neuropeptide YAgouti-related peptide17β-estradiolKCNQ channelsHigh-fat dietEnergy balance;
19.Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function

机译：小鼠和人骨骼肌干和祖细胞功能需要细胞外丝氨酸和甘氨酸
- 作者：Brandon J. Gheller;Jamie E. Blum;Esther W. Lim;Michal K. Handzlik;Ern Hwei Hannah Fong;Anthony C. Ko;Shray Khanna;Molly E. Gheller;Erica L. Bender;Matthew S. Alexander;Patrick J. Stover;Martha S. Field;Benjamin D. Cosgrove;Christian M. Metallo;Anna E. Thalacker-Mercer
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- MuscleMuscle regenerationMuscle stem cellMuscle progenitor cellProliferationMuscle metabolismSerine metabolismGlycine metabolismProtein synthesis;
20.Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction

机译：内皮氨基酶2通过诱导线粒体功能障碍介导视网膜缺血/再灌注损伤
- 作者：Esraa Shosha;Abdelrahman Y. Fouda;Tahira Lemtalsi;Stephen Haigh;David Fulton;Ahmed Ibrahim;Mohamed Al-Shabrawey;R. William Caldwell;Ruth B. Caldwell
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- RetinaIschemiaArginaseEndothelial cellsMitochondria;
21.Type 2 diabetes subgroups and potential medication strategies in relation to effects on insulin resistance and beta-cell function: A step toward personalised diabetes treatment?

机译：2型糖尿病亚组和潜在的药物治疗策略与对胰岛素抵抗和β细胞功能的影响有关：迈向个性化糖尿病治疗的步骤？
- 作者：Anna Veelen;Edmundo Erazo-Tapia;Jan Oscarsson;Patrick Schrauwen
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Type 2 diabetesPersonalised medicineDiabetes classificationβ-cell functionInsulin sensitivity;
22.Insulin and obesity transform hypothalamic-pituitary-adrenal axis stemness and function in a hyperactive state

机译：胰岛素和肥胖症在多动态转化下丘脑 - 垂体 - 肾上腺轴线茎干和功能
- 作者：Martin Werdermann;Ilona Berger;Laura D. Scriba;Alice Santambrogio;Pia Schlinkert;Heike Brendel;Henning Morawietz;Andreas Schedl;Mirko Peitzsch;Aileen J.F. King;Cynthia L. Andoniadou;Stefan R. Bornstein;Charlotte Steenblock
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- AdrenalPituitaryHPA axisProgenitorsObesityMetabolic stressACTH adrenocorticotropic hormoneAgRP agouti-related peptidebFGF basic fibroblast growth factorCRH corticotropin-releasing hormoneDMEM Dulbecco's modified Eagle mediumFACS fluorescence-activated cell sortingHBSS Hank's Balanced Salt SolutionHFD high-fat dietHPA hypothalamic-pituitary-adrenalND normal dietNPY neuropeptide YPBS phosphate-buffered salinePI propidium iodideT2D type 2 diabeteszF zona fasciculatazG zona glomerulosa;
23.Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle

机译：AMPKγ3的复合和纤维型选择性要求在骨骼肌中胰岛素无关的葡萄糖摄取
- 作者：Philipp Rhein;Eric M. Desjardins;Ping Rong;Danial Ahwazi;Nicolas Bonhoure;Jens Stolte;Matthieu D. Santos;Ashley J. Ovens;Amy M. Ehrlich;José L. Sanchez Garcia;Qian Ouyang;Julian M. Yabut;Mads Kjolby;Mathieu Membrez;Niels Jessen;Jonathan S. Oakhill;Jonas T. Treebak;Pascal Maire;John W. Scott;Matthew J. Sanders
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- AMP-activated protein kinase5-aminoimidazole-4-carboxamide ribosideMK-8722TBC1D1Brown adipose tissueBeige adipose tissue;
24.Adaptive thermogenesis in brown adipose tissue involves activation of pannexin-1 channels

机译：棕色脂肪组织中的自适应热生成涉及激活Pannexin-1通道
- 作者：Subramanian Senthivinayagam;Vlad Serbulea;Clint M. Upchurch;Renata Polanowska-Grabowska;Suresh K. Mendu;Srabani Sahu;Prathiba Jayaguru;Kevin W. Aylor;Mahendra D. Chordia;Limor Steinberg;Nathaniel Oberholtzer;Seichii Uchiyama;Noriko Inada;Ulrike M. Lorenz;Thurl E. Harris;Susanna R. Keller;Akshaya K. Meher;Alexandra Kadl;Bimal N. Desai;Bijoy K. Kundu
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- adipocytebrown adipose tissueThermogenesisPannexin channels;
25.SNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic β-cells

机译：支持标签的超分辨率成像显示胰腺β细胞中GPR56的组成型和激动剂依赖性贩运
- 作者：Oladapo E. Olaniru;Jordan Cheng;Julia Ast;Anastasia Arvaniti;Patricio Atanes;Guo C. Huang;Aileen J.F. King;Peter M. Jones;Johannes Broichhagen;David J. Hodson;Shanta J. Persaud
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- GPR56SNAP-tagTraffickingIsletsApoptosisCRISPR-Cas9;
26.Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling

机译：受体活性 - 改性蛋白2（RAMP2）改变胰高血糖素受体在受体信号传导的功能作用中携带肝细胞的肝细胞
- 作者：Emma Rose McGlone;Yusman Manchanda;Ben Jones;Phil Pickford;Asuka Inoue;David Carling;Stephen R. Bloom;Tricia Tan;Alejandra Tomas
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Glucagon receptorReceptor activity-modifying protein 2G protein-coupled receptorsEndocytic traffickingIntracellular signallingCarbohydrate metabolism;
27.Multicompartmental non-invasive sensing of postprandial lipemia in humans with multispectral optoacoustic tomography

机译：多光谱神声断层扫描中人类餐后脂质血症的多组分非侵袭性感应
- 作者：Nikolina-Alexia Fasoula;Angelos Karlas;Michael Kallmayer;Anamaria Beatrice Milik;Jaroslav Pelisek;Hans-Henning Eckstein;Martin Klingenspor;Vasilis Ntziachristos
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Cardiovascular riskFatHyperlipidemiaLipid metabolismMetabolic imagingPhotoacoustics;
28.The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic β-cells

机译：胰岛素分泌来自胰腺β细胞的胰岛素分泌需要ARFRP1依赖性高尔基替代蛋白GOPC
- 作者：Ilka Wilhelmi;Stephan Grunwald;Niclas Gimber;Oliver Popp;Gunnar Dittmar;Anup Arumughan;Erich E. Wanker;Thomas Laeger;Jan Schmoranzer;Oliver Daumke;Annette Schürmann
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Insulin secretionEndosomal sortingSNARE proteinstrans-Golgi networkARFRP1 ADP ribosylation factor-related protein 1GOPC Golgi-associated PDZ and coiled-coil motif-containing proteinGSIS glucose-stimulated insulin secretionICG insulin-containing granuleVPS35 vacuolar protein sorting-associated protein 35T2D type 2 diabetes;
29.Imaging biomarkers of NAFLD, NASH, and fibrosis

机译：NAFLD，NASH和纤维化的成像生物标志物
- 作者：Veeral Ajmera;Rohit Loomba
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- NAFLDMRINASHSignificant fibrosisMR ElastographyMRI-PDFF;
30.Adipocyte integrin-linked kinase plays a key role in the development of diet-induced adipose insulin resistance in male mice

机译：adipocyte整联蛋白联系激酶在饮食诱导的脂肪胰岛素抵抗力中发挥关键作用，在雄性小鼠中
- 作者：Aimée R. Bugler-Lamb;Annie Hasib;Xiong Weng;Chandani K. Hennayake;Chenshi Lin;Rory J. McCrimmon;Roland H. Stimson;Michael L.J. Ashford;David H. Wasserman;Li Kang
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Adipose tissueExtracellular matrixInsulin clampInsulin resistanceIntegrin-linked kinase;
31.Characterization of viral insulins reveals white adipose tissue-specific effects in mice

机译：病毒胰岛素的表征揭示了在小鼠中的白色脂肪组织特异性作用
- 作者：Martina Chrudinová;Fran?ois Moreau;Hye Lim Noh;Terezie Páníková;Lenka ?áková;Randall H. Friedline;Francisco A. Valenzuela;Jason K. Kim;Ji?í Jirá?ek;C. Ronald Kahn;Emrah Altindis
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- VILPsViral insulinInsulinIGF-1GLUT4Adipose tissueGlucose metabolismViral mimicryVILP viral insulin/IGF-like peptidesc single chaindc double chainGIV Grouper iridovirusSGIV Singapore grouper iridovirusLCDV-1 Lymphocystis disease virus 1;
32.Epidermal Acyl-CoA-binding protein is indispensable for systemic energy homeostasis

机译：表皮酰基 - CoA结合蛋白是全身能量稳态的必要条件
- 作者：Ditte Neess;Vibeke Kruse;Ann-Britt Marcher;Mie Rye W?de;Julie Vistisen;Pauline M. M?ller;Rikke Petersen;Jonathan R. Brewer;Tao Ma;Georgia Colleluori;Ilenia Severi;Saverio Cinti;Zach Gerhart-Hines;Susanne Mandrup;Nils J. F?rgeman
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Epidermal barrierEnergy expenditureAdipose tissueBrowningDiet induced obesityβ-adrenergic signalingAcyl-CoA binding proteinFilaggrin;
33.The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

机译：Melanocortin途径和能量稳态：从发现到肥胖治疗
- 作者：Giles S.H. Yeo;Daniela Herrera Moro Chao;Anna-Maria Siegert;Zoe M. Koerperich;Mark D. Ericson;Stephanie E. Simonds;Courtney M. Larson;Serge Luquet;Iain Clarke;Shubh Sharma;Karine Clément;Michael A. Cowley;Carrie Haskell-Luevano;Lex Van Der Ploeg;Roger A.H. Adan
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- MelanocortinHypothalamusObesityGeneticsPharmacologyTherapy;
34.“A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes”

机译：“一跳结论？针对Ghrelin系统治疗肥胖和糖尿病“
- 作者：Deepali Gupta;Sean B. Ogden;Kripa Shankar;Salil Varshney;Jeffrey M. Zigman
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- GhrelinGHSRLEAP2GOATObesityDiabetesGH Growth hormoneGHSR Growth hormone secretagogue receptorGOAT Ghrelin O -acyltransferaseKO KnockoutLEAP2 Liver-enriched antimicrobial peptide 2MRAP2 Melanocortin receptor accessory protein-2PWS Prader–Willi SyndromeZDF Zucker diabetic fatty;
35.Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models

机译：糖尿病多变疗养和神经元模型中镁和甲基乙醛之间的相互作用
- 作者：Alexander Strom;Klaus Strassburger;Martin Schmuck;Hanna Shevalye;Eric Davidson;Fariba Zivehe;Gidon B?nhof;Rudolph Reimer;Bengt-Frederik Belgardt;Thomas Fleming;Barbara Biermann;Volker Burkart;Karsten Müssig;Julia Szendroedi;Mark A. Yorek;Ellen Fritsche;Peter P. Nawroth;Michael Roden;Dan Ziegler
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Recent-onset type 2 diabetesDiabetic sensorimotor polyneuropathyCarbonyl stressMethylglyoxalHypomagnesemiaAGEs Advanced glycation end-productsBSA bovine serum albuminDRG dorsal root gangliaDSPN diabetic sensorimotor polyneuropathyGDS German Diabetes StudyGLO1 glyoxalase 1GLO2 Glyoxalase 2PDH pyruvate dehydrogenasePFA paraformaldehydeTDT thermal detection threshold;
36.Deconstructing the origins of sexual dimorphism in sensory modulation of pancreatic β cells

机译：解构胰腺β细胞感觉调节中性二晶的起源
- 作者：Sara McEwan;Hyokjoon Kwon;Azeddine Tahiri;Nivetha Shanmugarajah;Weikang Cai;Jin Ke;Tianwen Huang;Ariana Belton;Bhagat Singh;Le Wang;Zhiping P. Pang;Ercument Dirice;Esteban A. Engel;Abdelfattah El Ouaamari
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Sex differenceIslet β cellsSensory neuronsGlucose homeostasis;
37.Nampt controls skeletal muscle development by maintaining Ca2 homeostasis and mitochondrial integrity

机译：Nampt通过维持Ca2稳态和线粒体完整来控制骨骼肌开发
- 作者：Astrid L. Basse;Marianne Agerholm;Jean Farup;Emilie Dalbram;Joachim Nielsen;Niels ?rtenblad;Ali Alt?nta?;Amy M. Ehrlich;Thomas Krag;Santina Bruzzone;Morten Dall;Roldan M. de Guia;Jonas B. Jensen;Andreas B. M?ller;Anders Karlsen;Michael Kj?r;Romain Barrès;John Vissing;Steen Larsen;Niels Jessen
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Cyclophilin DMitochondrial permeability transition pore (mPTP)MyopathyNADNicotinamide ribosideSarcopenia;
38.CD81 marks immature and dedifferentiated pancreatic β-cells

机译：CD81标志着未成熟和消化的胰腺β细胞
- 作者：Ciro Salinno;Maren Büttner;Perla Cota;Sophie Tritschler;Marta Tarquis-Medina;Aimée Bastidas-Ponce;Katharina Scheibner;Ingo Burtscher;Anika B?ttcher;Fabian J. Theis;Mostafa Bakhti;Heiko Lickert
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- β-CellsCD81MaturationImmatureHeterogeneityDedifferentiation;
39.Amylin receptor insensitivity impairs hypothalamic POMC neuron differentiation in the male offspring of maternal high-fat diet-fed mice

机译：淀粉蛋白受体内敏感性损害母体高脂饮食喂养小鼠的雄性后代的下丘脑POMC神经元分化
- 作者：Cheng Li;Jing-Jing Xu;Hong-Tao Hu;Chao-Yi Shi;Chuan-Jin Yu;Jian-Zhong Sheng;Yan-Ting Wu;He-Feng Huang
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- AmylinRamp3POMC neuronsMaternal high-fat dietmRNA stability;
40.Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans

机译：非酒精性脂肪肝病（NAFLD）从发病机制到人类治疗概念
- 作者：Kalliopi Pafili;Michael Roden
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Fatty liverLipotoxicityInflammationFibrosisInsulin resistanceClinical trials;
41.Regulation of hepatic circadian metabolism by the E3 ubiquitin ligase HRD1-controlled CREBH/PPARα transcriptional program

机译：E3泛素连接酶HRD1受控CREBH /PPARα转录计划调节肝昼夜核代谢
- 作者：Hyunbae Kim;Juncheng Wei;Zhenfeng Song;Emilio Mottillo;Lobelia Samavati;Ren Zhang;Li Li;Xuequn Chen;Bhanu P. Jena;Jiandie D. Lin;Deyu Fang;Kezhong Zhang
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Endoplasmic reticulumER-associated degradationLipid metabolismCircadian metabolismTranscriptional regulationER endoplasmic reticulumERAD ER-associated degradationHRD1 HMG-CoA reductase degradation 1 homologSel1L SEL1L adaptor subunit of ERAD E3 ubiquitin ligaseCREBH cAMP-responsive element-binding proteinhepatic-specificPPARα peroxisome proliferator–activated receptor αBMAL1 aryl hydrocarbon receptor nuclear translocator-like protein 1UPR unfolded protein responseLC3 microtubule-associated protein 1A/1B-light chain 3PPARα peroxisome proliferator-activated receptor αATG7 autophagy-related protein 7BMAL1 brain and muscle ARNT-Like 1PCK1 phosphoenolpyruvate carboxykinase 1G6PC glucose-6-phosphatase catalytic subunitFA fatty acidsTG triglycerideBOH beta-hydroxybutyrateKO knockoutCTL control.;
42.Myosin 1c: A novel regulator of glucose uptake in brown adipocytes

机译：肌球蛋白1C：棕色脂肪细胞中葡萄糖摄取的新型调节因素
- 作者：Alice ?slund;Muhammad Hamza Bokhari;Erika Wetterdal;René Martin;Hans-Joachim Kn?lker;Tore Bengtsson
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Brown adipose tissueMyosin 1cGLUT1PKAp38ATF-2;
43.Hepatic synthesis of triacylglycerols containing medium-chain fatty acids is dominated by diacylglycerol acyltransferase 1 and efficiently inhibited by etomoxir

机译：含有培养基脂肪酸的三酰基甘油的肝化合成由二酰基甘油酰基转移酶1主导，并有效地被Etomoxir抑制
- 作者：Klaus Wunderling;Christina Leopold;Isabell Jamitzky;Mohamed Yaghmour;Fabian Zink;Dagmar Kratky;Christoph Thiele
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- MCFAMetabolic tracingEtomoxirTeglicar;
44.Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice

机译：在Delta细胞中，游离脂肪酸受体4抑制信号传导调节小鼠中的胰岛激素分泌物
- 作者：Marine L. Croze;Marcus F. Flisher;Arthur Guillaume;Caroline Tremblay;Glyn M. Noguchi;Sabrina Granziera;Kevin Vivot;Vincent C. Castillo;Scott A. Campbell;Julien Ghislain;Mark O. Huising;Vincent Poitout
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- FFAR4GPR120SomatostatinInsulinGlucagonIslet of langerhans;
45.Notum deacylates octanoylated ghrelin

机译：令人毛骨悚然的辛酸辛烷酯
- 作者：Yuguang Zhao;Laura-Nadine Schuhmacher;Morgan Roberts;Satoshi Kakugawa;Ganka Bineva-Todd;Steve Howell;Nicola OReilly;Christine Perret;Ambrosius P. Snijders;Jean-Paul Vincent;E. Yvonne Jones
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- NotumGhrelinDeacylationCrystal structureMetabolism;
46.HSP60 reduction protects against diet-induced obesity by modulating energy metabolism in adipose tissue

机译：通过调节脂肪组织中的能量代谢来防止饮食诱导的肥胖症免受饮食诱发的肥胖
- 作者：Robert Hauffe;Michaela Rath;Mareike Schell;Katrin Ritter;Kai Kappert;Stefanie Deubel;Christiane Ott;Markus J?hnert;Wenke Jonas;Annette Schürmann;André Kleinridders
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- MitochondriaStress responseObesityGlucose homeostasisInsulin resistanceAdipose tissue;
47.Hepatokines and metabolism: Deciphering communication from the liver

机译：肝运动量和新陈代谢：从肝脏中解密通信
- 作者：Sharon O. Jensen-Cody;Matthew J. Potthoff
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- HepatokineLiverObesityNutrientInsulin sensitivityGlucose homeostasis;
48.Genetic deletion of the ghrelin receptor (GHSR) impairs growth and blunts endocrine response to fasting in Ghsr-IRES-Cre mice

机译：Ghrelin受体的遗传缺失（GHSR）在GHSR-IRES-CRE小鼠中捕获生长和钝性的内分泌反应
- 作者：Fiona Peris-Sampedro;Iris Stoltenborg;Marie V. Le May;Jeffrey M. Zigman;Roger A.H. Adan;Suzanne L. Dickson
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- GhrelinGhsrIRESCre miceGrowthGrowth hormoneIGF-1Arcuate nucleus;
49.Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes

机译：缺氧诱导脂质液滴相关诱导DGAT1并促进肝细胞中的脂质储存
- 作者：Montserrat A. de la Rosa Rodriguez;Lei Deng;Anne Gemmink;Michel van Weeghel;Marie Louise Aoun;Christina Warnecke;Rajat Singh;Jan Willem Borst;Sander Kersten
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Lipid dropletsLiverHILPDADGAT1Fluorescence microscopyTriglyceride synthesis;
50.Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression

机译：早期诱导肝脏脱碘酶1型抑制NAFLD进展期间的肝胃蛋白病
- 作者：Eveline Bruinstroop;Jin Zhou;Madhulika Tripathi;Winifred W. Yau;Anita Boelen;Brijesh Kumar Singh;Paul M. Yen
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- LiverSteatosisThyroidNAFLDDeiodinaseNASH;
51.Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia

机译：肝细胞特异性葡萄糖-6-磷酸酶缺乏缺陷血小板聚集并减少禁食低血糖时血液单核细胞
- 作者：Anouk M. La Rose;Venetia Bazioti;Joanne A. Hoogerland;Arthur F. Svendsen;Anouk G. Groenen;Martijn van Faassen;Martijn G.S. Rutten;Niels J. Kloosterhuis;Bertien Dethmers-Ausema;J. Hendrik Nijland;Gilles Mithieux;Fabienne Rajas;Folkert Kuipers;Micha?l V. Lukens;Oliver Soehnlein;Maaike H. Oosterveer;Marit Westerterp
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Glycogen storage disease type 1aHypoglycemiaCorticosteroneMonocytesPlatelets;
52.Tissue-specific expression of Cas9 has no impact on whole-body metabolism in four transgenic mouse lines

机译：Cas9的组织特异性表达对四种转基因小鼠线的全身代谢没有影响
- 作者：Simon T. Bond;Aowen Zhuang;Christine Yang;Eleanor A.M. Gould;Tim Sikora;Yingying Liu;Ying Fu;Kevin I. Watt;Yanie Tan;Helen Kiriazis;Graeme I. Lancaster;Paul Gregorevic;Darren C. Henstridge;Julie R. McMullen;Peter J. Meikle;Anna C. Calkin;Brian G. Drew
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- CRISPRCas9Transgenic miceMetabolismTissue specificPhenotype;
53.Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis

机译：活性整合蛋白调节白色脂肪组织胰岛素敏感性和棕色脂肪热生成
- 作者：Francisco Javier Ruiz-Ojeda;Jiefu Wang;Theresa B?cker;Martin Krueger;Samira Zamani;Simon Rosowski;Tim Gruber;Yasuhiro Onogi;Annette Feuchtinger;Tim J. Schulz;Reinhard F?ssler;Timo D. Müller;Cristina García-Cáceres;Matthias Meier;Matthias Blüher;Siegfried Ussar
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- IntegrinsKindlin-2Insulin resistanceAdipose tissueObesityBrown fatInsulin receptorLipodystrophy;
54.Sensory neurons derived from diabetic rats exhibit deficits in functional glycolysis and ATP that are ameliorated by IGF-1

机译：衍生自糖尿病大鼠的感觉神经元表现出通过IGF-1改善的功能性糖酵解和ATP的缺陷
- 作者：Mohamad-Reza Aghanoori;Vicky Margulets;Darrell R. Smith;Lorrie A. Kirshenbaum;Daniel Gitler;Paul Fernyhough
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- ATP biosensorsAxon regenerationBioenergeticsDiabetic neuropathyMitochondrial respirationNeurite outgrowth;
55.Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression

机译：抑制胰岛素诱导的基因1（INSIG1）功能促进肝脂质重塑并抑制纳什进展
- 作者：Vian Azzu;Michele Vacca;Ioannis Kamzolas;Zoe Hall;Jack Leslie;Stefania Carobbio;Samuel Virtue;Susan E. Davies;Agnes Lukasik;Martin Dale;Mohammad Bohlooly-Y;Animesh Acharjee;Daniel Lindén;Guillaume Bidault;Evangelia Petsalaki;Julian L. Griffin;Fiona Oakley;Michael E.D. Allison;Antonio Vidal-Puig
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Non-alcoholic fatty liver disease (NAFLD)De novo lipogenesis (DNL)Lipid remodellingWestern dietCarbon tetrachloride (CCl 4 )Liver regeneration;
56.Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR–v-ATPase axis

机译：通过靶向内体MTOR-V-ATPase轴，特异性氨基酸补充从脂质过载诱导的胰岛素抗性和收缩功能障碍中救出心脏
- 作者：Shujin Wang;Francesco Schianchi;Dietbert Neumann;Li-Yen Wong;Aomin Sun;Frans A. van Nieuwenhoven;Maurice P. Zeegers;Agnieszka Strzelecka;Umare Col;Jan F.C. Glatz;Miranda Nabben;Joost J.F.P. Luiken
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Vacuolar H -ATPaseEndosomal CD36mTORC1Lipid-induced insulin resistanceContractile functionDiabetic heart;
57.Mono and dual agonists of the amylin, calcitonin, and CGRP receptors and their potential in metabolic diseases

机译：丙氨酸，降钙素和CGRP受体的单声道和双激动剂及其代谢疾病的潜力
- 作者：Nina Sonne;Morten A. Karsdal;Kim Henriksen
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- AmylinCGRPDACRAInsulin sensitivityDiabetesObesityTreatmentsPreclinicalPharmacologyReceptors;
58.Essential roles of insulin and IGF-1 receptors during embryonic lineage development

机译：胰岛素和IGF-1受体在胚胎谱系发展中的基本作用
- 作者：Erin R. Okawa;Manoj K. Gupta;Sevim Kahraman;Praneeth Goli;Masaji Sakaguchi;Jiang Hu;Kaiti Duan;Brittany Slipp;Jochen K. Lennerz;Rohit N. Kulkarni
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Insulin/IGF-1 receptorsPluripotencyLineage developmentSignalingApoptosis;
59.Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD

机译：肝脂液滴：NAFLD储能和代谢功能障碍之间的平衡行动
- 作者：Douglas G. Mashek
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Lipid dropletsLipotoxicityNAFLDNASHPerilipins;
60.Hepatocyte miR-34a is a key regulator in the development and progression of non-alcoholic fatty liver disease

机译：肝细胞miR-34a是非酒精脂肪肝病的开发和进展中的关键调节因素
- 作者：Yanyong Xu;Yingdong Zhu;Shuwei Hu;Xiaoli Pan;Fathima Cassim Bawa;Helen H. Wang;David Q.-H. Wang;Liya Yin;Yanqiao Zhang
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- miR-34aNAFLDLipogenesisLipid absorptionBile acids;
61.miR-126 contributes to the epigenetic signature of diabetic vascular smooth muscle and enhances antirestenosis effects of Kv1.3 blockers

机译：MiR-126有助于糖尿病血管平滑肌的表观遗传签名，并提高KV1.3阻滞剂的抗抗病作用
- 作者：Marycarmen Arevalo-Martinez;Pilar Cidad;Sara Moreno-Estar;Mirella Fernández;Sebastian Albinsson;Irene Cózar-Castellano;José R. López-López;M. Teresa Pérez-Garcia
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Vascular remodelingType 2 diabetes mellitusVascular smooth muscleKv1.3 channel blockersmiRNAsCell proliferation;
62.GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans

机译：GLP-1和饥饿调节激励动机取决于人类的胰岛素敏感性
- 作者：Ruth Hanssen;Alina Chloé Kretschmer;Lionel Rigoux;Kerstin Albus;Sharmili Edwin Thanarajah;Tamara Sitnikow;Corina Melzer;Oliver A. Cornely;Jens C. Brüning;Marc Tittgemeyer
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Glucagon-like peptide-1Insulin sensitivityRegulation of motivational behaviourObesityHunger;
63.Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease

机译：非酒精脂肪肝疾病中的核受体和转录调控
- 作者：Yang Xiao;Mindy Kim;Mitchell A. Lazar
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Non-alcoholic fatty liver disease (NAFLD)Non-alcoholic steatohepatitis (NASH)Nuclear receptors (NRs)Transcriptional regulation;
64.A physiological glucocorticoid rhythm is an important regulator of brown adipose tissue function

机译：生理糖皮质激素节律是棕色脂肪组织功能的重要调节因子
- 作者：Jan Kroon;Maaike Schilperoort;Wietse In het Panhuis;Rosa van den Berg;Lotte van Doeselaar;Cristy R.C. Verzijl;Nikki van Trigt;Isabel M. Mol;Hetty H.C.M. Sips;Jose K. van den Heuvel;Lisa L. Koorneef;Ronald J. van der Sluis;Anna Fenzl;Florian W. Kiefer;Sabine Vettorazzi;Jan P. Tuckermann;Nienke R. Biermasz;Onno C. Meijer;Patrick C.N. Rensen;Sander Kooijman
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Brown adipose tissueCircadian RhythmCorticosteroneGlucocorticoid receptor;
65.Whole-brain activation signatures of weight-lowering drugs

机译：减肥药的全脑激活特征
- 作者：Henrik H. Hansen;Johanna Perens;Urmas Roostalu;Jacob Lercke Skytte;Casper Gravesen Salinas;Pernille Barkholt;Ditte Dencker Thorbek;Kristoffer T.G. Rigbolt;Niels Vrang;Jacob Jelsing;Jacob Hecksher-S?rensen
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- ImagingiDISCOLight sheet fluorescence microscopyc-FosObesityAnti-Obesity drugs;
66.Small intestinal taurochenodeoxycholic acid-FXR axis alters local nutrient-sensing glucoregulatory pathways in rats

机译：小肠牛磺酸辛酸酸-FXR轴改变了大鼠的局部营养感测葡萄糖术路径
- 作者：T.M. Zaved Waise;Yu-Mi Lim;Zahra Danaei;Song-Yang Zhang;Tony K.T. Lam
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Small intestineNutrient sensingGlucose toleranceBile acidsFXRUSI Upper small intestineHF high-fatTCDCA taurochenodeoxycholic acidFXR farnesoid X receptorLgasseri Lactobacillus gasseri;
67.A viral insulin-like peptide is a natural competitive antagonist of the human IGF-1 receptor

机译：病毒胰岛素样肽是人IGF-1受体的天然竞争性拮抗剂
- 作者：Fa Zhang;Emrah Altindis;C. Ronald Kahn;Richard D. DiMarchi;Vasily Gelfanov
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- InsulinInsulin-like growth factor 1IGF-1Peptide synthesisReceptor antagonismVirus-derived peptides;
68.Obesity alters ovarian folliculogenesis through disrupted angiogenesis from increased IL-10 production

机译：肥胖症通过中断IL-10生产中断的血管生成而改变卵巢卵泡发生
- 作者：Po-Kai Yang;Chia-Hung Chou;Chu-Chun Huang;Wen-Fen Wen;Hsin-Fu Chen;Chia-Tung Shun;Hong-Nerng Ho;Mei-Jou Chen
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Obesogenic dietInterleukin-10Visceral adiposityOvarian folliclesAnti-angiogenesis;
69.A multicomponent screen for feeding behaviour and nutritional status in Drosophila to interrogate mammalian appetite-related genes

机译：一种多组分筛选，用于果蝇喂养行为和营养状况，以询问哺乳动物食欲相关基因
- 作者：J. Chalmers;Y.C.L. Tung;C.H. Liu;C.J. OKane;S. ORahilly;G.S.H. Yeo
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- AppetiteFood intakeGWASTranscriptomicsDrosophilaObesity;
70.TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality

机译：TFEB缺乏症耐磨褐色脂肪组织美白在热屈光度下的线粒体降解
- 作者：Frederike Sass;Christian Schlein;Michelle Y. Jaeckstein;Paul Pertzborn;Michaela Schweizer;Thorsten Schinke;Andrea Ballabio;Ludger Scheja;Joerg Heeren;Alexander W. Fischer
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- TFEBBrown adipose tissueWhiteningMitophagyThermogenesisUCP1;
71.Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity

机译：营养不良骨骼肌的代谢重塑揭示了肌营养不良蛋白和尿素适应和可塑性的生物学作用
- 作者：Justin P. Hardee;Karen J.B. Martins;Paula M. Miotto;James G. Ryall;Stefan M. Gehrig;Boris Reljic;Timur Naim;Jin D. Chung;Jen Trieu;Kristy Swiderski;Ashleigh M. Philp;Andrew Philp;Matthew J. Watt;David A. Stroud;Rene Koopman;Gregory R. Steinberg;Gordon S. Lynch
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Muscular dystrophyMuscle adaptationDystrophinUtrophinOxidative metabolism;
72.Ube2i deletion in adipocytes causes lipoatrophy in mice

机译：Ube2i在adipocytes中删除导致小鼠的脂肪养
- 作者：Aaron R. Cox;Natasha Chernis;Kang Ho Kim;Peter M. Masschelin;Pradip K. Saha;Shawn M. Briley;Robert Sharp;Xin Li;Jessica B. Felix;Zheng Sun;David D. Moore;Stephanie A. Pangas;Sean M. Hartig
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Ube2iLipodystrophyAdipose tissueLipid metabolism;
73.The miR-200–Zeb1 axis regulates key aspects of β-cell function and survival in?vivo

机译：miR-200-Zeb1轴调节β细胞功能的关键方面，并在β-细胞功能和生存中
- 作者：Alexandra C. Title;Pamuditha N. Silva;Svenja Godbersen;Lynn Hasen?hrl;Markus Stoffel
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- β-cell dedifferentiationEpithelial-to-mesenchymal transitionDouble-negative feedback loopIslet aggregationER stressmicroRNAEMT epithelial-to-mesenchymal transitionEMT TF EMT transcription factorT2D type 2 diabetesT1D type 1 diabetesmiRNA microRNAUPR unfolded protein responseMET mesenchymal-to-epithelial transitionTg thapsigarginGSIS glucose-stimulated insulin secretioniPSC induced pluripotent stem cells;
74.Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling

机译：线粒体穴位酶的丧失通过SCD1介导的脂质重塑促进结肠直肠癌进展
- 作者：Xin You;Jingyu Tian;Hui Zhang;Yunhua Guo;Jing Yang;Chaofeng Zhu;Ming Song;Peng Wang;Zexian Liu;John Cancilla;Wenhua Lu;Christophe Glorieux;Shijun Wen;Hongli Du;Peng Huang;Yumin Hu
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Mitochondrial aconitaseColon cancerTricarboxylic acid (TCA) cycleLipogenesisStearoyl-CoA desaturase;
75.Identification of novel GPCR partners of the central melanocortin signaling

机译：鉴定中央素质素信令的新型GPCR合作伙伴
- 作者：Yunpeng Li;Xiaozhu Wang;Liumei Lu;Meng Wang;Yue Zhai;Xiaolu Tai;Diliqingna Dilimulati;Xiaowei Lei;Jing Xu;Cong Zhang;Yanbin Fu;Shen Qu;Qingfeng Li;Chao Zhang
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- MC3RMC4RGPCRSingle cell RNA-SeqEnergy homeostasisDimerization;
76.Nuclear hormone and peptide hormone therapeutics for NAFLD and NASH

机译：NAFLD和NASH的核激素和肽激素治疗方法
- 作者：Brian Finan;Sebastian D. Parlee;Bin Yang
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Nuclear hormonePeptide hormoneNAFLDNASHClinical data;
77.A guide to understanding endoplasmic reticulum stress in metabolic disorders

机译：理解代谢障碍内质网胁迫的指南
- 作者：Imke L. Lemmer;Nienke Willemsen;Nazia Hilal;Alexander Bartelt
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- ObesityEndoplasmic reticulumInflammationAutophagyUPR;
78.Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network

机译：广泛的Neurog3在人胰腺内分泌基因监管网络中占用
- 作者：Valérie Schreiber;Reuben Mercier;Sara Jiménez;Tao Ye;Emmanuel García-Sánchez;Annabelle Klein;Aline Meunier;Sabitri Ghimire;Catherine Birck;Bernard Jost;Kristian Honnens de Lichtenberg;Christian Honoré;Palle Serup;Gérard Gradwohl
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- NEUROG3iPSCIslet progenitorsCUTRUNT2DMSNPs;
79.Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis

机译：细胞代谢中的磷酸胆酚丙酯羧基酶：角色和机制超出葡糖生成
- 作者：Shuo Yu;Simin Meng;Meixiang Xiang;Hong Ma
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Phosphoenolpyruvate carboxykinase (PCK)GluconeogenesisGlyceroneogenesisTranscription regulationPosttranscription regulationEpigenetic regulationProtein kinase;
80.Physiological impact of in?vivo stable isotope tracing on cancer metabolism

机译：体内稳定同位素追踪癌代谢的生理影响
- 作者：Manuel Grima-Reyes;Adriana Martinez-Turtos;Ifat Abramovich;Eyal Gottlieb;Johanna Chiche;Jean-Ehrland Ricci
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Stable isotope tracingTracer administrationInterorgan exchangeFastingTumor metabolism;
81.The absence of hepatic glucose-6 phosphatase/ChREBP couple is incompatible with survival in mice

机译：没有肝葡萄糖-6磷酸酶/ Chrebp夫妇与小鼠的存活不相容
- 作者：Fabienne Rajas;Renaud Dentin;Alexane Cannella Miliano;Marine Silva;Margaux Raffin;Fran?oise Levavasseur;Amandine Gautier-Stein;Catherine Postic;Gilles Mithieux
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Glucose productionGlucose-6 phosphateGlycaemiaGlycogen storage disease type 1Non-alcoholic fatty liver diseaseType 2 diabetesAspartate aminotransferase ASTalanine aminotransferase ALTcarbohydrate response element-binding protein ChREBPendogenous glucose production EGPfree fatty acid FFAglucose-6 phosphatase G6Paseglucose-6 phosphate G6Pnon-alcoholic fatty liver disease NAFLDnon-esterified fatty acid NEFAtriglycerides TGvery low-density lipoproteins VLDLwild-type WT;
82.The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans

机译：ILE191VAL是TAS1R2甜味受体的部分函数变体，并且与人类的降低的葡萄糖偏移有关
- 作者：Joan Serrano;Jaroslava Seflova;Jihye Park;Marsha Pribadi;Keisuke Sanematsu;Noriatsu Shigemura;Vanida Serna;Fanchao Yi;Andrea Mari;Erik Procko;Richard E. Pratley;Seth L. Robia;George A. Kyriazis
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Sweet taste receptorsTAS1R2rs35874116PolymorphismOGTTIntestiners9701796sweet taste receptors (STR)extracellular domain (ECD)ligand binding domain (LBD)fluorescence lifetime imaging microscopy (FLIM)plasma membrane (PM);
83.Defective insulin-stimulated GLUT4 translocation in brown adipocytes induces systemic glucose homeostasis dysregulation independent of thermogenesis in female mice

机译：抗胰岛素刺激的胰岛素刺激的Glut4易位在棕色脂肪细胞中诱导全身葡萄糖稳态失调与女性小鼠的热生成无关
- 作者：Belén Picatoste;Lucie Yammine;Rosemary A. Leahey;David Soares;Emma F. Johnson;Paul Cohen;Timothy E. McGraw
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Brown adipose tissueRab10GLUT4Glucose homeostasisDiabetes;
84.Missense variant in insulin receptor (Y1355H) segregates in family with fatty liver disease

机译：胰岛素受体中的畸形变异（Y1355H）含有脂肪肝病的家庭中的偏见
- 作者：Fei Luo;Chao Xing;Sumeet K. Asrani;Shili Li;Guosheng Liang;Helen H. Hobbs;Jonathan C. Cohen
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- AutophosphorylationHepatic triglycerideSterol regulatory element-binding protein 1c (SREBP-1c);
85.FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice

机译：FOXO1抑制与FGF21促进了糖尿病小鼠中的葡萄糖对照
- 作者：Yun-Kyoung Lee;Bryan Diaz;Marianne Deroose;Samuel X. Lee;Sandro Belvedere;Domenico Accili;Rudolph L. Leibel;Hua V. Lin
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- FOXO1DiabetesHepatic glucose productionFGF21AS1842856Compound 10;
86.MTORC1 inhibition drives crinophagic degradation of glucagon

机译：MTORC1抑制驱动胰高血糖素的粪便降解
- 作者：Sangam Rajak;Sherwin Xie;Archana Tewari;Sana Raza;Yajun Wu;Boon-Huat Bay;Paul M. Yen;Rohit A. Sinha
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- AutophagyCrinophagyDiabetesGlucagonLysosomesMTORC1Rapamycin;
87.Testosterone metabolites differentially regulate obesogenesis and fat distribution

机译：睾酮代谢物差异调节血清发生和脂肪分布
- 作者：Zachary L. Sebo;Matthew S. Rodeheffer
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- ObesityDiabetesTestosteroneFat distributionAdipogenesis;
88.Maternal obesity persistently alters cardiac progenitor gene expression and programs adult-onset heart disease susceptibility

机译：母亲肥胖持续改变心脏祖母基因表达和课程成人发病心脏病易感性
- 作者：Abdalla Ahmed;Minggao Liang;Lijun Chi;Yu-Qing Zhou;John G. Sled;Michael D. Wilson;Paul Delgado-Olguín
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Heart disease susceptibilityFetal programming of heart diseaseMaternal obesityCardiac progenitorsGene expressionNkx2-5Myocardial remodeling;
89.Correlation guided Network Integration (CoNI) reveals novel genes affecting hepatic metabolism

机译：相关引导网络集成（CONI）揭示了影响肝新陈代谢的新型基因
- 作者：Valentina S. Klaus;Sonja C. Schriever;José Manuel Monroy Kuhn;Andreas Peter;Martin Irmler;Janina Tokarz;Cornelia Prehn;Gabi Kastenmüller;Johannes Beckers;Jerzy Adamski;Alfred K?nigsrainer;Timo D. Müller;Martin Heni;Matthias H. Tsch?p;Paul T. Pfluger;Dominik Lutter
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Data integrationHepatic steatosisMulti-omicsSystems biology;
90.KATP channel blockers control glucagon secretion by distinct mechanisms: A direct stimulation of α-cells involving a [Ca2 ]c rise and an indirect inhibition mediated by somatostatin

机译：KATP通道阻断通过不同机制控制胰高血糖素分泌：直接刺激涉及[CA2] C的α-细胞和由生长抑制素介导的间接抑制
- 作者：Bilal Singh;Firas Khattab;Heeyoung Chae;Lieven Desmet;Pedro L. Herrera;Patrick Gilon
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Pancreatic isletsSulfonylureasCa 2GlucagonSomatostatinCa 2 c free cytosolic Ca 2 concentrationGIRK channels G protein-gated inwardly rectifying K channelsK ATP channels ATP-sensitive K channelsSST somatostatinSSTR somatostatin receptorsTPNQ tertiapin-QVGCC voltage-gated Ca 2 channels;
91.Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice

机译：在D-β-羟基丁酯脱氢酶肝细胞缺乏小鼠中减少酮互联，肝TCA循环通量和葡萄糖产量
- 作者：David B. Stagg;Jacob R. Gillingham;Alisa B. Nelson;Justin E. Lengfeld;D. André d’Avignon;Patrycja Puchalska;Peter A. Crawford
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Mitochondrial redox homeostasisHepatic ketogenesisLiver oxidative metabolismGlucose metabolismMetabolomicsMetabolic flux;
92.The Mediator complex kinase module is necessary for fructose regulation of liver glycogen levels through induction of glucose-6-phosphatase catalytic subunit (G6pc)

机译：通过诱导葡萄糖-6-磷酸酶催化亚基（G6PC），介质复合激酶模块是肝糖原水平的果糖调节所必需的
- 作者：Dou Yeon Youn;Alus M. Xiaoli;Haihong Zong;Junichi Okada;Li Liu;Jacob Pessin;Jeffrey E. Pessin;Fajun Yang
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Mediator complexKinase moduleFructoseG6pcLiver glycogen;
93.Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial–mesenchymal transition in diabetes

机译：Dyefferentiatedβ-细胞中Pdx1 / ovol2 / Zeb2轴的缺点触发了与糖尿病中上皮 - 间充质转换相关的基因的诱导
- 作者：Daniel S. de Jesus;Tracy C.S. Mak;Yi-Fang Wang;Yorrick von Ohlen;Ying Bai;Eva Kane;Pauline Chabosseau;Catherine M. Chahrour;Walter Distaso;Victoria Salem;Alejandra Tomas;Markus Stoffel;Guy A. Rutter;Mathieu Latreille
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- DiabetesInsulinPancreatic β-cellsDedifferentiationEpithelial-to-mesenchymal transitionmicroRNAβ-TFs β-cell transcription factorsECM extracellular matrixFACS fluorescence-activated cell sortingGSIS glucose-induced stimulated-insulin secretionGSEA gene set enrichment analysismicroRNA miRNAscRNA-seq single-cell RNA sequencingT1D type 1 diabetesT2D type2 diabetesUPR unfolded protein response;
94.N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production

机译：N-酰基苯胺胺氨基胺水解1通过抑制过氧缺血性生物发生诱导的ROS生产来促进黑素瘤生长和转移
- 作者：Parmanand Malvi;Radoslav Janostiak;Arvindhan Nagarajan;Xuchen Zhang;Narendra Wajapeyee
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- MelanomaCeramideASAH1ROSPeroxisomeCancer therapeutics;
95.Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease

机译：胰岛素抵抗在非酒精脂肪肝疾病中机械地连接到肝线粒体重塑
- 作者：Chris E. Shannon;Mukundan Ragavan;Juan Pablo Palavicini;Marcel Fourcaudot;Terry M Bakewell;Ivan A. Valdez;Iriscilla Ayala;Eunsook S. Jin;Muniswamy Madesh;Xianlin Han;Matthew E. Merritt;Luke Norton
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Insulin resistanceMetabolic liver diseaseMitochondriaThiazolidinedioneCardiolipinPyruvate dehydrogenase;
96.Neonatal overfeeding during lactation rapidly and permanently misaligns the hepatic circadian rhythm and programmes adult NAFLD

机译：新生儿在泌乳期间迅速过量，永久性错位肝昼夜节律和计划成年人NAFLD
- 作者：Francesc Ribas-Aulinas;Silvia Ribo;Marcela Parra-Vargas;Antonio Fernández-Pérez;Judith Cebrià;Maria Guardiola-Perello;Marta Ramon-Krauel;Carles Lerin;Ruben Diaz;Susana G. Kalko;Mario Vallejo;Antoni Díez-Noguera;Trinitat Cambras;Josep C. Jimenez-Chillaron
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Developmental origins of health and disease (DOHaD)Childhood obesityCircadian rhythmLitter size reductionTime-restricted feeding (TRF)Non-alcoholic fatty liver disease (NAFLD);
97.Histone H3K9 butyrylation is regulated by dietary fat and stress via an Acyl-CoA dehydrogenase short chain-dependent mechanism

机译：组蛋白H3K9丁酰基化由膳食脂肪和胁迫通过酰基 - 辅酶脱氢酶短链依赖性机制调节
- 作者：Zhi Yang;Minzhen He;Julianne Austin;Jessica Pfleger;Maha Abdellatif
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- butyrylationH3K9BuACADSCardiac hypertrophyEpigeneticsH3K9Ac;
98.Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation

机译：通过硒蛋白的上调乙醇胺磷脂合成I.在T细胞活化期间需要有效的代谢重编程。
- 作者：Chi Ma;FuKun W. Hoffmann;Michael P. Marciel;Kathleen E. Page;Melodie A. Williams-Aduja;Ellis N.L. Akana;Greg S. Gojanovich;Mariana Gerschenson;Johann Urschitz;Stefan Moisyadi;Vedbar S. Khadka;Sharon Rozovsky;Youping Deng;F. David Horgen;Peter R. Hoffmann
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- SeleniumSelenoproteinPhosphatidylethanolamineEthanolamine phosphotransferaseMetabolic sensingAMPKGlycolysisAAG 1-alkylacylglycerolAMPK AMP-activated protein kinaseBUB1 benzimidazoles 1CEPT1 choline/ethanolamine phosphotransferase 1CCNE1 cyclin E1CDP cytidine 5-diphosphateDAG diacylglycerolDEGs differentially expressed genesE2F3 E2F transcription factor 3ER endoplasmic reticulumGPI glycosylphosphatidylinositolGPAA1 GPI anchor attachment protein 1KO knockoutPPP pentose phosphate pathwayPE phosphatidylethanolamineSELENOI selenoprotein ITCR T cell receptorWT wild-type;
99.Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists

机译：Spatiotemporal GLP-1和GIP受体信号传导和贩运/回收/回收/再循环动力学由选定的受体单和双激动剂诱导
- 作者：Aaron Novikoff;Shannon L. OBrien;Miriam Bernecker;Gerald Grandl;Maximilian Kleinert;Patrick J. Knerr;Kerstin Stemmer;Martin Klingenspor;Anja Zeigerer;Richard DiMarchi;Matthias H. Tsch?p;Brian Finan;Davide Calebiro;Timo D. Müller
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- GLP-1RGIPRBiased agonismReceptor InternalizationReceptor TraffickingDual-agonists;
100.Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis

机译：核受体铁芯压力器，Ncor1和SMRT，需要维持全身代谢稳态
- 作者：Megan J. Ritter;Izuki Amano;Norihiro Imai;Lorraine Soares De Oliveira;Kristen R. Vella;Anthony N. Hollenberg
- 期刊名称：《Molecular Metabolism》 | 2021年第a期
- Gene repressionThyroid hormoneNuclear corepressorsEF ejection fractionHPT hypothalamic pituitary thyroid axisIPGTT intraperitoneal glucose tolerance testOGTT oral glucose tolerance testPTT pyruvate tolerance testTG triglyceridesTH thyroid hormoneTR thyroid hormone receptorTSH thyroid stimulation hormone;

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