Adaptor protein LNK promotes anaplastic thyroid carcinoma cell growth via 14-3-3 ε/γ binding

摘要

ATC cells exhibit increased LNK expression. The mRNA and protein expression levels of LNK were significantly higher in ATC tissues than in DTC and normal thyroid tissues, as measured by real-time PCR and IHC, respectively. The protein and mRNA expression levels of LNK were significantly higher in the ATC cell lines (ARO, FRO, SW579, 8305C) than in the DTC cell lines (KTC-1, KAT-5, B-CPAP) and a thyroid follicular epithelial cell line (Nthy-ori-3-1), as measured by western blot and real-time PCR, respectively