TP53 Arg72Pro polymorphism and neuroblastoma susceptibility in eastern Chinese children: a three-center case–control study

摘要

is a tumor suppressor gene that regulates cell growth, apoptosis and DNA repair. Previous studies have reported the contribution of Arg72Pro (rs1042522 C>G) polymorphism to pathogenesis of multiple tumors. Hence, we evaluated the association between this polymorphism and neuroblastoma susceptibility in eastern Chinese children. The Taqman genotyping assay was performed in 373 patients and 762 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of the association. No significant association was found between the gene rs1042522 C>G polymorphism and neuroblastoma susceptibility in the overall analysis (CG vs. CC: adjusted OR = 0.92, 95% CI = 0.70–1.22, =0.567; GG vs. CC: adjusted OR = 0.99, 95% CI = 0.69–1.42, =0.947; CG/GG vs. CC: adjusted OR = 0.94, 95% CI = 0.72–1.23, =0.639; or GG vs. CC/CG: adjusted OR = 1.04, 95% CI = 0.75–1.43, =0.814) and stratified analysis by age, gender, sites of origin, and clinical stages. The gene rs1042522 C>G polymorphism may not be a risk factor for neuroblastoma in eastern Chinese children. Future studies are needed to confirm this negative result and to reveal additional functional variants predisposing to neuroblastoma.