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Inhibition Requirements of the human Apical Sodium-dependent Bile acid Transporter (hASBT) using Aminopiperidine Conjugates of glutamyl-Bile Acids

机译：使用谷氨酸胆碱酸的氨基哌啶缀合物抑制人体顶点依赖性胆汁酸转运蛋白（HASBT）的抑制要求

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摘要

PurposeSynthesize aminopiperidine conjugates of glutamyl-bile acids (glu-BAs) and develop a hASBT inhibition model using the conformationally sampled pharmacophore (CSP) approach.

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期刊名称 other
作者
Pablo M. González; Chayan Acharya; Alexander D. MacKerell Jr.; James E. Polli;
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年(卷),期 -1(26),7
年度 -1
页码 1665–1678
总页数 28
原文格式 PDF
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关键词
Apical Sodium-dependent Bile acid Transporter bile acid transporter conformationally sampled pharmacophore CHARMM;

机译：根尖钠依赖性胆汁酸转运蛋白;胆汁酸;转运蛋白;构象采样的药效团;CHARMM;

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专利

1. Inhibition Requirements of the Human Apical Sodium-Dependent Bile Acid Transporter (hASBT) Using Aminopiperidine Conjugates of glutamyl-Bile Acids [J] . Pablo M. González, Chayan Acharya, Alexander D. MacKerell, Pharmaceutical Research . 2009,第7期

机译：谷氨酰胺-胆汁酸的氨基哌啶结合物对人类根尖钠依赖性胆汁酸转运蛋白（hASBT）的抑制要求
2. Inhibition requirements of the human apical sodium-dependent bile acid transporter (hASBT) using aminopiperidine conjugates of glutamyl-bile acids. [J] . Gonzalez PM, Acharya C, Mackerell AD Jr Pharmaceutical research . 2009,第7期

机译：使用谷氨酰胆汁酸的氨基哌啶共轭物对人根尖钠依赖性胆汁酸转运蛋白（hASBT）的抑制要求。
3. Structural requirements of the human sodium-dependent bile acid transporter (hASBT): Role of 3- and 7-OH moieties on binding and translocation of bile acids [J] . GonzálezP.M., LagosC.F., WardW.C., Molecular pharmaceutics . 2014,第2期

机译：人类钠依赖性胆汁酸转运蛋白（hASBT）的结构要求：3-和7-OH部分对胆汁酸结合和转运的作用
4. Aqueous Phase Sonogashira Cross-Coupling Reaction in Synthesis of Bile Acid Conjugates of Purine and Pyrimidine Nucleosides and Nucleoside Triphosphates; Towards Bile Acid -Functionalized Nucleic Acids [C] . Satu Ikonen, Radek Pohl, Michal Hocek European Symposium on Organic Chemistry . 2009

机译：水相Sonogashira交叉偶联反应在嘌呤和嘧啶核苷的合成中合成，嘧啶核苷和核苷三磷酸盐;朝向胆汁酸 - 官能化核酸
5. Inhibition and substrate requirements of human apical sodium-dependent bile acid transporter (ASBT) and its potential as a prodrug target. [D] . Zheng, Xiaowan. 2010

机译：人类根尖钠依赖性胆汁酸转运蛋白（ASBT）的抑制和底物要求及其作为前药靶标的潜力。
6. Structural requirements of the human sodium-dependent bile acid transporter (hASBT): Role of 3- and 7-OH moieties on binding and translocation of bile acids [O] . Pablo M. González, Carlos F. Lagos, Weslyn C. Ward, -1

机译：人类钠依赖性胆汁酸转运蛋白（hASBT）的结构要求：3-和7-OH部分对胆汁酸结合和转运的作用
7. Interaction of Native Bile Acids with Human Apical Sodium-Dependent Bile Acid Transporter (hASBT): Influence of Steroidal Hydroxylation Pattern and C-24 Conjugation [O] . Anand Balakrishnan, Stephen A. Wring, James E. Polli 2006

机译：天然胆汁酸与人体顶端依赖性胆汁酸转运蛋白（HASBT）的相互作用：甾体羟基化图案和C-24缀合的影响
8. Specific Bile Acid Radioimmunoassays for Separate Determinations of Unconjugated Cholic Acid, Conjugated Cholic Acid and Conjugated Deoxycholic Acid in Serum and Their Clinical Application [R] . Matern, S., Gerok, W. 1977

机译：特异性胆汁酸放射免疫分析法分离测定血清中非共轭胆酸，共轭胆酸和共轭脱氧胆酸及其临床应用

Inhibition Requirements of the human Apical Sodium-dependent Bile acid Transporter (hASBT) using Aminopiperidine Conjugates of glutamyl-Bile Acids

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