Volatile anesthetics attenuate oxidative stress-reduced activity of glutamate transporter type 3

摘要

BackgroundVolatile anesthetics enhance the activity of glutamate transporter type 3 (also called excitatory amino acid transporter type 3, EAAT3), the major neuronal EAAT. In addition to glutamate, EAAT3 can also uptake L-cysteine, the rate-limiting substrate for the synthesis of glutathione. Our previous study showed that oxidative stress inhibited glutamate-induced EAAT3 activity. We determined whether oxidative stress would reduce L-cysteine-induced EAAT3 activity and whether this reduction would be attenuated by volatile anesthetics.