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Prolonged CD154 Expression on Pediatric Lupus CD4 T Cells Correlates with Increased CD154 Transcription Increased NFAT Activity and Glomerulonephritis

机译：儿科狼疮的CD4 T细胞相关因素延长CD154表达具有增加的CD154转录增加NFaT活性和肾小球性肾炎

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ObjectiveTo assess CD154 expression in pediatric lupus and explore a transcriptional mechanism explaining dysregulated CD154 expression.

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Jay Mehta; Anna Genin; Michael Brunner; Lisabeth V Scalzi; Nilamadhab Mishra; Timothy Beukelman; Randy Q Cron;
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年(卷),期 -1(62),8
年度 -1
页码 2499–2509
总页数 18
原文格式 PDF
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1. Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription, increased nuclear factor of activated T cell activity, and glomerulonephritis [J] . Jay Mehta, Anna Genin, Michael Brunner, Arthritis & Rheumatism . 2010,第8期

机译：小儿狼疮患者CD4 T细胞上CD154的延长表达与CD154转录增加，活化T细胞活性的核因子增加以及肾小球肾炎有关
2. Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription, increased nuclear factor of activated T cell activity, and glomerulonephritis [J] . MehtaJ., GeninA., BrunnerM., Arthritis and Rheumatism . 2010,第8期

机译：小儿狼疮患者CD4 T细胞上CD154的延长表达与CD154转录增加，活化T细胞活性的核因子增加以及肾小球肾炎有关
3. Levels of Soluble CD40 Ligand (CD154) in Serum Are Increased in Human Immunodeficiency Virus Type 1-Infected Patients and Correlate with CD4+ T-Cell Counts [J] . Nikolaos V. Sipsas, Petros P. Sfikakis, Athanasios Kontos, Clinical and diagnostic laboratory immunology . 2002,第3期

机译：在人类免疫缺陷病毒1型感染的患者中血清中可溶性CD40配体（CD154）的水平升高，并与CD4 + T细胞计数相关
4. Increased bradykinin Bl receptor expression in diabetic placental tissue correlates with both hyperhistaminaemia and increased histidine decarboxylase (HDC) activity [C] . DARIUSZ SZUKIEWICZ, MICHAL PYZLAK, HABIB ALKHALAYLA, Recent researches in modern medicine . 2011

机译：糖尿病胎盘组织中缓激肽B1受体表达的增加与高组氨酸血症和组氨酸脱羧酶（HDC）活性相关
5. Graft antigen-specific CD4+ T cells require CD154 expression to clonally expand and differentiate to the TH1 phenotype and initiate mTOR dependant intimal hyperplasia in cardiac allografts. [D] . Huddleston, Stephen James. 2009

机译：嫁接抗原特异性CD4 + T细胞需要CD154表达才能克隆扩增并分化为TH1表型，并在心脏同种异体移植中引发mTOR依赖性内膜增生。
6. Increased expression of CD40 ligand (CD154) on CD4+ T cells as a marker of disease activity in rheumatoid arthritis [O] . B. Berner, G. Wolf, K. Hummel, 2000

机译：CD40 + T细胞上CD40配体（CD154）的表达增加是类风湿关节炎疾病活动的标志
7. Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription, increased nuclear factor of activated T cell activity, and glomerulonephritis [O] . Jay Mehta, Anna Genin, Michael Brunner, 2010

机译：CD154对来自小儿狼疮患者的CD4 T细胞的延长表达与CD154转录增加，增加了活化T细胞活性的核因素，以及肾小球肾炎
8. Costimulation of T Cell Receptor/CD3-Mediated Activation of Resting Human CD4+ TCells by Leukocyte Function-Associated Antigen-1 Ligand Intercellular Cell Adhesion Molecule-1 Involves Prolonged Inositol Phospholipid Hydrolysis and Sustained Increase of In [R] . Van Seventer, G. A., Bonvini, E., Yamada, H., 1992

机译：白细胞功能相关抗原-1配体细胞间粘附分子-1的T细胞受体/ CD3介导的静息人CD4 + TCell活化共刺激涉及延长的肌醇磷脂水解和持续增加的In

Prolonged CD154 Expression on Pediatric Lupus CD4 T Cells Correlates with Increased CD154 Transcription Increased NFAT Activity and Glomerulonephritis

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