首页> 外国专利> Device for immunochromatographico and semi quantitative method for the determination of HIV / AIDS via measurement of soluble CD40 ligand / CD154, a CD4 + T cell equivalent and the detection simultu00e1nea of infection of HIV via detection of HIV antibody.

Device for immunochromatographico and semi quantitative method for the determination of HIV / AIDS via measurement of soluble CD40 ligand / CD154, a CD4 + T cell equivalent and the detection simultu00e1nea of infection of HIV via detection of HIV antibody.

机译:免疫层析法和半定量法通过测定可溶性CD40配体CD154,CD4 + T细胞当量和通过检测HIV抗体同时检测HIV感染来测定HIV / AIDS的装置。

摘要

Device for lmmunochromatographico and semi quantitative method for the determination of HIV / AIDS via measurement of soluble CD4O ligand / CD154, a CD4 + T cell and equivalent to simultaneously detect HIV infection via the detection of antibody to HIV. Lnciui one or more support materials capable of providing lateral flow.The one or more support materials include at least one reception area of the sample to receive a biological sample containing a first analyte target, the first analyte target being a CD4 + cell equivalent of 1, such as soluble CD4O ligand / CD 154 and a second analyte target, the social security The world analyte target and an antibody to HIV.A second area, situated in one or more support materials, has a ligand detector or detector and movelmente contained antigens, in which the ligand detector and or antigenos detector is able to form a complex with the cell ligand soluble CD4O / 154 and or HIV antibodies.And at least one first area of capture and an amount determined in advance from a first reagent property of capture, the capture reagent property capable of specifically binding to the complex formed by the mobile ligand soluble protein and ligand CD4O / 154 of detector and forn Ecer a visible sign.The one or more support materials further have located it at least a second capture area having a predetermined quantity of a second capture reagent that is capable of call property specifically HIV antibodies present in the biological sample, and to provide a signal visu00edve L.
机译:用于通过测定可溶性CD4O配体CD154,CD4 + T细胞和等效物的免疫层析法和半定量法测定HIV / AIDS的装置,通过检测HIV抗体同时检测HIV感染。一种或多种能够提供侧向流动的支持材料。一种或多种支持材料包括样品的至少一个接收区域,以接收包含第一分析物靶标的生物样品,该第一分析物靶标的CD4 +细胞当量为1 ,例如可溶性CD4O配体/ CD 154和第二种分析物靶标,社会安全性世界分析物靶标和HIV抗体。第二种区域位于一种或多种支持材料中,具有配体检测器或检测器和运动器抗原,其中配体检测器和/或反抗原检测器能够与细胞配体可溶性CD4O // 154和/或HIV抗体形成复合物,并且至少有一个第一捕获区域以及根据第一试剂性质预先确定的量在捕获时,捕获试剂的性能能够特异性结合检测剂和Ecer的可移动配体可溶性蛋白和配体CD4O / 154形成的复合物,并具有明显的信号。更多的支持材料进一步将其定位在至少第二捕获区域,该区域具有预定量的第二捕获试剂,该第二捕获试剂能够调用生物样品中存在的特定的HIV抗体的特性,并提供相对于L的信号。

著录项

  • 公开/公告号BRPI1004526A2

    专利类型

  • 公开/公告日2012-10-30

    原文格式PDF

  • 申请/专利权人 MILLENIUM BIOTECHNOLOGY INC.;

    申请/专利号BR2010PI04526

  • 发明设计人 PAUL REITER;

    申请日2010-05-27

  • 分类号G01N33/569;

  • 国家 BR

  • 入库时间 2022-08-21 17:25:24

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