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Efficacy and Safety of AmBisome in Combination with Sodium Stibogluconate or Miltefosine and Miltefosine Monotherapy for African Visceral Leishmaniasis: Phase II Randomized Trial

机译：AmBisome联合葡糖酸葡萄糖酸钠或米替福辛联合米替福辛单药治疗非洲内脏利什曼病的疗效和安全性：II期随机试验

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BackgroundSSG&PM over 17 days is recommended as first line treatment for visceral leishmaniasis in eastern Africa, but is painful and requires hospitalization. Combination regimens including AmBisome and miltefosine are safe and effective in India, but there are no published data from trials of combination therapies including these drugs from Africa.

机译：背景技术建议将17天以上的SSG＆PM作为东部非洲内脏利什曼病的一线治疗方法，但它很痛苦，需要住院治疗。在印度，包括AmBisome和miltefosine在内的联合用药是安全有效的，但是尚无来自非洲的包括这些药物在内的联合疗法试验的公开数据。

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期刊名称 PLoS Neglected Tropical Diseases
作者
Monique Wasunna; Simon Njenga; Manica Balasegaram; Neal Alexander; Raymond Omollo; Tansy Edwards; Thomas P. C. Dorlo; Brima Musa; Mohammed Hassan Sharaf Ali; Mohammed Yasein Elamin; George Kirigi; Rashid Juma; Anke E. Kip; Gerard J. Schoone; Asrat Hailu; Joseph Olobo; Sally Ellis; Robert Kimutai; Susan Wells; Eltahir Awad Gasim Khalil; Nathalie Strub Wourgaft; Fabiana Alves; Ahmed Musa;
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年(卷),期 2016(10),9
年度 2016
页码 e0004880
总页数 18
原文格式 PDF
正文语种
中图分类寄生动物、寄生虫学;医学寄生虫学;
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专利

1. Safety and Efficacy of miltefosine alone and in combination with sodium stibogluconate and liposomal amphotericin B for the treatment of primary visceral leishmaniasis in East Africa: study protocol for a randomized controlled trial [J] . Raymond Omollo, Neal Alexander, Tansy Edwards, Trials . 2011,第1期

机译：单用米非磷碱以及与stibogluconate钠和脂质体两性霉素B组合治疗东非原发性内脏利什曼病的安全性和有效性：一项随机对照试验的研究方案
2. A randomized trial of AmBisome monotherapy and AmBisome and miltefosine combination to treat visceral leishmaniasis in HIV co-infected patients in Ethiopia [J] . Ermias Diro, Severine Blesson, Tansy Edwards, PLOS Neglected Tropical Diseases . 2019,第1期

机译：AmBisome单一疗法与AmBisome和miltefosine联合治疗埃塞俄比亚HIV合并感染患者的内脏利什曼病的随机试验
3. Pharmacokinetics, Safety, and Efficacy of an Allometric Miltefosine Regimen for the Treatment of Visceral Leishmaniasis in Eastern African Children: An Open-label, Phase II Clinical Trial [J] . Mbui Jane, Olobo Joseph, Omollo Raymond, Clinical infectious diseases . 2019,第9期

机译：各种Miltefosine治疗的药代动力学，安全性和功效治疗东部非洲儿童内脏丽山症性：开放标签，II期临床试验
4. A double-blind, randomized phase II trial of thesafety and immunogenicity of 26-valent group A streptococcus vaccine in healthy adults [C] . Shelly A. McNeil, Scott A. Halperin, Joanne M. Langley, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

机译：一种双盲，随机期II试验，对健康成人的26岁的26岁群体的疫苗疫苗
5. Bayesian Sequential Randomization Designs for Phase III Clinical Trials. [D] . Zhu, Han. 2016

机译：III期临床试验的贝叶斯顺序随机设计。
6. Safety and Efficacy of miltefosine alone and in combination with sodium stibogluconate and liposomal amphotericin B for the treatment of primary visceral leishmaniasis in East Africa: study protocol for a randomized controlled trial [O] . Raymond Omollo, Neal Alexander, Tansy Edwards, 2011

机译：单用米非磷碱以及与stibogluconate钠和脂质体两性霉素B联合治疗东非原发性内脏利什曼病的安全性和有效性：一项随机对照试验的研究方案
7. Efficacy and Safety of AmBisome in Combination with Sodium Stibogluconate or Miltefosine and Miltefosine Monotherapy for African Visceral Leishmaniasis: Phase II Randomized Trial. [O] . Monique Wasunna, Simon Njenga, Manica Balasegaram, 2016

机译：amBisome联合葡萄糖酸钠或米替福新和米替福新单药治疗非洲内脏利什曼病的疗效和安全性：II期随机试验。

Efficacy and Safety of AmBisome in Combination with Sodium Stibogluconate or Miltefosine and Miltefosine Monotherapy for African Visceral Leishmaniasis: Phase II Randomized Trial

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