High yield and high specific activity synthesis of 18FFallypride in a batch microfluidic reactor for micro-PET imaging

摘要

[¹⁸F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65±6% (n=7) and an average specific activity of 730 GBq/μmol (20 Ci/μmol) (n=4). Specific activity was ~2-fold higher than [¹⁸F]fallypride synthesized on a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip.