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首页> 外文期刊>Chemical Communications >High yield and high specific activity synthesis of [~(18)F]fallypride in a batch microfluidic reactor for micro-PET imaging
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High yield and high specific activity synthesis of [~(18)F]fallypride in a batch microfluidic reactor for micro-PET imaging

机译：在用于微型PET成像的间歇式微流反应器中高产率高比活合成[〜（18）F]氟利昂

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摘要

[~(18)F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65 ± 6% (n = 7) and an average specific activity of 730 GBq μmol~(-1) (20 Ci μmol~(-1)) (n = 4). Specific activity was ～2-fold higher than [~(18)F]fallypride synthesized in a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip.
机译：[〜（18）F] falpride在一批微流控芯片中合成，放射化学产率为65±6％（n = 7），平均比活度为730 GBqμmol〜（-1）（20 Ciμmol〜（- 1））（n = 4）。比活性比大型放射性合成仪合成的[〜（18）F]氟利昂高约2倍，尽管在微芯片中开始时放射性明显较低，因此条件更安全。

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  • 来源
    《Chemical Communications》 |2014年第10期|1192-1194|共3页
  • 作者

    Muhammad Rashed Javed; Supin Chen; Jack Lei; Jeffrey Collins; Maxim Sergeev; Hee-Kwon Kim; Chang-Jin Kim; R. Michael van Dam; Pei Yuin Keng;

  • 作者单位

    Department of Molecular Imaging and Medical Pharmacology, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, USA,Crump Institute for Molecular Imaging, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, USA;

    Bioengineering Department, University of California Los Angeles, 420 Westwood Plaza, Los Angeles, USA;

    Department of Molecular Imaging and Medical Pharmacology, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, USA,Crump Institute for Molecular Imaging, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, USA;

    Crump Institute for Molecular Imaging, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, USA;

    Department of Molecular Imaging and Medical Pharmacology, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, USA,Crump Institute for Molecular Imaging, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, USA;

    Department of Molecular Imaging and Medical Pharmacology, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, USA,Crump Institute for Molecular Imaging, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, USA;

    Bioengineering Department, University of California Los Angeles, 420 Westwood Plaza, Los Angeles, USA,Mechanical and Aerospace Engineering Department, University of California Los Angeles, 420 Westwood Plaza, Los Angeles, USA;

    Department of Molecular Imaging and Medical Pharmacology, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, USA,Crump Institute for Molecular Imaging, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, USA,Bioengineering Department, University of California Los Angeles, 420 Westwood Plaza, Los Angeles, USA;

    Department of Molecular Imaging and Medical Pharmacology, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, USA,Crump Institute for Molecular Imaging, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, USA;

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  • 入库时间 2022-08-17 13:15:00

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